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| 1 | Inflammatory bowel disease: A descriptive study of 716 local Chilean patients显示文摘AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our group.METHODS: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD(P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery(P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC(55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution. CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. | Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera | 2016 | World Journal of Gastroenterology2016，22，22： | 2 |
| 2 | Outback catheter for femoropopliteal occlusions: immediate and long-term results显示文摘 | Bausback Y Botsios S Flux J | 2011 | J Endovasc Ther2011，18，1： | 1 |
| 3 | cerevisiae显示文摘 | Galazzao JL Bailey JE Fermentation pathway kinetics and metabolic flux control in suspended and immobilized S | 1990 | Enzyme Microbio Technol1990，12，： | 1 |
| 4 | Solitary lesion on finger:A quiz显示文摘 | Streit E Hortschuh W Flux K | 2013 | Acta Dermatol Venereological2013，93，： | 1 |
| 5 | Application of the linearquadratic model to combined modality radiotherapy显示文摘 | Bodey RK Evans PM Flux GD | | 0，，01： | 1 |
| 6 | Effects of fatty acids on skeletal muscle cell differentiation in vitro 显示文摘 | HURLEY M S FLUX C SALTER AM | 2006 | Br J Nutr2006，95，3： | 1 |
| 7 | Acid - Base Status, and Blood Gasea in Rainbow Trout,Salmo Gairdner Exposed to Toxic Zinc in Natural Soft Water显示文摘 | SPRY D J WOOD C M ION FLUX RATES | 1985 | Can J Fish Aquat Sci1985，42，： | 1 |
| 8 | Tryptophan deficiency in pigs:changes in food intake and plasma levels of glucose,amino acids,insulin and growth hormone显示文摘 | Montgomery G W Flux D S Greenway R N | 1980 | Horm Metab Res1980，12，： | 1 |
| 9 | A dose-effect correlationfor radioiodine ablation in differentiated thyroid cancer显示文摘 | Flux GD Haq M Chittenden SJ | 2010 | Eur JNucl Med Mol Imaging2010，37，2： | 1 |
| 10 | Sweetman Bill显示文摘 | | 2002 | Jane''s Navy International2002，107，4： | 1 |
| 11 | FDG-PET in the prediction of survival of patients with cancer of the pancreas: a pilot study 显示文摘 | Maisey NR Webb A Flux GD | 2000 | Br J Cancer2000，83，3： | 1 |
| 12 | Effects of MMF Harmonics on Rotor Ed- dy-Current Losses for Inner-Rotor Fractional Slot Axial Flux Per- manent Magnet Synchronous Machines显示文摘 | Heat Transfer of an Axial- Flux IEEE Transactions on Magnetics Li Jian Da-Woon Choi | 2012 | IEEE Trans on Mag- netics2012，48，2： | 1 |
| 13 | FDG-PET in the prediction of survival of padents with cancer of the pancreas: a pilot study显示文摘 | Maisey NR Webb A Flux GD | 2000 | Br J Cancer2000，83，3： | 1 |
| 14 | Meyerson-Phenomenon hides a nevus flammeus显示文摘 | Simon V Hartschuh W Flux K | 2011 | J Dtsch Dermatol Ges2011，9，4： | 1 |
| 15 | Outback catheter for femoropopliteal occlusions: immediate and long-term results显示文摘 | Bausback Y Botsios S Flux J | 2011 | J Endovasc Ther2011，18，1： | 1 |
| 16 | Congenital spindle cell naevus with unusual transformation: proliferative nodule or melanoma? 显示文摘 | Flux K Hartschuh W | 2012 | Acta Derm Venereol2012，92，2： | 1 |
| 17 | Introduction and overview of the lagomorphs in rabbits, hares and pikas显示文摘 | Chapman J A Flux J E C | 2012 | Status Survey and Conservation Action Plan IUCN Gland Switzerland2012，1，： | 1 |
| 18 | Effect of feeding rumen- protected conjugated linoleic acid on carcass characteristics and fatty acid composition of sheep tissues显示文摘 | Wynn R J Daniel Z C T R Flux C L | 2006 | J anita sci2006，84，： | 1 |
| 19 | Effect of feeding rumen-protected conjugated linoleic acid on carcass characteristics and fatty acid composition of sheep tissues显示文摘 | Wynn R J Daniel Z C T R Flux C L | 2006 | Journal of Animal Science2006，84，12： | 1 |
| 20 | Outback catheter for femoropopliteal occlusions:immediate and long-term results显示文摘 | Bausback Y Botsios S Flux J | | 0，，： | 1 |
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