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| 1 | Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma显示文摘瞄准:为了评估免疫, interleukin-6 ( IL-6 )和从有肝细胞癌( HCC )和浆液的病人的肿瘤组织标本上的 IL-6 受体( IL-6R )的组织化学的本地化与 HCC 以及肝肝硬化( LC )在一组病人 IL-6 和 sIL-6R 铺平在一组有独自一个的 LC 并且在一个控制组的病人。方法:三组题目被学习:组我(n = 83 ) 受不了 HCC 和 LC,组 II (n = 72 ) 受不了独自一个的 LC 和组 III (n = 42 ) 同样健康的控制。所有病人有丙肝病毒感染。浆液 IL-6 和 IL-6R 层次用一个商业地可得到的 ELISA 工具包被决定。Immunohistochemistry 对 IL-6 和 IL-6R 用 streptavidin-biotin 建筑群和兔子 polyclonal 抗体被执行。结果:Immunohistochemistry 分析显示出媒介到强壮细胞质并且为 IL-6 和 IL-6R 的膜反应分别地在 HCC 的至少 40% 盒子,而肝肝硬化病人和控制为 IL-6 是否定的或为 IL-6R 显示出很温和、焦点的像点的细胞质的反应。在 HCC 组的浆液 IL-6 层次比在 LC 和控制组的那些显著地高(P <
0.0001 ) 。在在 3 个组之中的 sIL-6R 集中没有有效差量。当有 HCC 的病人根据 Okuda 的分类被划分成组时, IL-6 和 sIL-6R 水平的重要浆液增加从舞台被观察我上演 III (P <
0.02, P <
0.0005 ) 。当 HCC 和 LC 病人根据孩子呸被划分成肝硬化严厉的 3 个班时,在 HCC 病人的价值比在为各相应的班的 LC 病人的那些显著地高(P <
0.01 ).CONCLUSION:在 HCC 病人的 IL-6 浆液层次比在 LC 病人和控制的那些高,建议由肿瘤的房间的这 cytokine 的增加的生产。sIL-6R 价值在所有组是类似的,仅仅在阶段 III HCC 病人增加。这些数据建议他们与肿瘤的团而非与剩余的工作有一种更靠近的关系肝的质量。 | Soresi Maurizio Giannitrapani Lydia D'Antona Fabio Florena Ada Maria La Spada Emanuele Terranova Angela Cervello Melchiorre D'Alessandro Natale Montalto Giuseppe | 2006 | World Journal of Gastroenterology2006，12，16： | 25 |
| 2 | Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis显示文摘AIM: To investigate the association of cyclooxygenase-2(COX-2) expression with angiogenesis and the number and type of inflammatory cells (macrophages/Kupffer cells;mast cells) within primary hepatocellular carcinoma (HCC)tissues and adjacent non-tumorous (MT) tissues.METHODS: Immunohistochemistry for COX-2, CD34,CD68 and mast cell tryptase (MCT) was performed on 14 well-characterized series of liver-cirrhosis-associated HCC patients. COX-2 expression and the number of inflammatory cells in tumor lesions and surrounding liver tissues of each specimen were compared. Moreover,COX-2, CD34 staining and the number of inflammatory cells in areas with different histological degrees within each tumor sample were comparatively analyzed.RESULTS: The percentage of COX-2 positive cells was significantly higher in NT tissues than in tumors. COX-2 expression was higher in well-differentiated HCC than in poorly-differentiated tissues. Few mast cells were observed within the tumor mass, whereas a higher number was observed in the surrounding tissue, especially in peri-portal spaces of NT tissues. Abundant macrophages/Kupffer cells were observed in NT tissues, whereas the number of cells was significantly lower in the tumor mass.However, a higher cell number was observed in the well-differentiated tumor and progressively decreased in relation to the differentiation grade. Within the tumor, a positive correlation was found between COX-2 expression and the number of macrophages/Kupffer cells and mast cells. Moreover, there was a positive correlation between CD34 and COX-2 expression in tumor tissues. Comparison between well- and poorly-differentiated HCC showed that the number of CD34-positive cells decreased with dedifferentiation. However, COX-2 was the only independent variable showing a positive correlation with CD34 in a multivariate analysis.CONCLUSION: The presence of inflammatory cells and COX-2 expression in liver tumor suggests a possible relationship with tumor angiogenesis. COX-2 expressing cells and the number of macrophages/Kupffer cells and mast cells decrease with progression of the disease. | Melchiorre Cervello Daniela Foderà Ada Maria Florena Maurizio Soresi Claudio Tripodo Natale D'Alessandro Giuseppe Montalto | 2005 | World Journal of Gastroenterology2005，11，30： | 21 |
| 3 | CD27 distinguishes two phases in bone marrow infiltration of splenic marginal zone lymphoma显示文摘 | Florena AM Ascani S | 2004 | Histopathology2004，44，4： | 1 |
| 4 | Bone marrow biopsy in hemophagocytic syndrome 显示文摘 | Iannitto E Quintini G | 2002 | Virchows Arch2002，441，4： | 1 |
| 5 | Bilateral hairy polyp of the oropharynx 显示文摘 | Franco V Florena A M Lombardo F | 1996 | J Laryngol Otol1996，110，3： | 1 |
| 6 | Solid variant of mammary “adenoid cystic carcima with basaloid features” merging with “small cell carcinoma”显示文摘 | Cabibi D Cipolla C Maria Florena A | 2005 | Pathol Res Pract2005，201，10： | 1 |
| 7 | Bone marrow biopsy in hemophagocytic syndrome显示文摘 | Florena AM Iannitto E Quintini G | 2002 | Virchows Arch2002，441，4： | 1 |
| 8 | Splenic marginal zone lymphoma显示文摘 | Vito Franco Ada Maria Florena Emilio Iannitto | 2003 | Blood2003，101，： | 1 |
| 9 | Primary schwannoma of the thyroid gland involving the isthmus:report of a case显示文摘 | Graceffa G Cipolla C Florena AM | 2013 | Surg Today2013，43，1： | 1 |
| 10 | Splenectomy influences bone marrow infiltration in patients with splenic marginal zone cell lymphoma with or without villous lymphocytes显示文摘 | Franco V Florena AM Stella M | 2001 | Cancer2001，91，： | 1 |
| 11 | Spleneetomy influences bone marrow infiltration in patients with splenic marginal zone cell lymphoma with or without villous lymphoeytes显示文摘 | Franeo V Florena AM Stella M | | 0，，02： | 1 |
| 12 | Bilateral hairy polyp of the oropharynx显示文摘 | Franco V Florena A M Lombardo F Restivo S | 1996 | J Laryngol Otol1996，110，3： | 1 |
| 13 | Fecal Calprotectin in Clinical Practice: A Noninvasive Screening Tool for Patients With Chronic Diarrhea显示文摘 | Anna Licata Claudia Randazzo Maria Cappello Vincenza Calvaruso Giuseppe Butera Ada M. Florena Sergio Peralta Calogero Cammà Antonio Craxì | 2012 | Journal of Clinical Gastroenterology2012，，6： | 1 |
| 14 | Splenic marginal zone lymphoma 显示文摘 | Franco V Florena A M Iannitto E | 2003 | Blood2003，101，： | 1 |
| 15 | Gamma-delta T-cell lymphomas 显示文摘 | Tripodo C Iannitto E Florena AM | 2009 | Nat Rev Clin Oncol2009，6，12： | 1 |
| 16 | Intrasinusoidal bone marrow infiltration:a possible hallmark of splenic lymphoma 显示文摘 | Franco V Florena A M Campesi G | 1996 | Histopatbol1996，29，： | 1 |
| 17 | Primary schwannoma of the thyroid gland involving the isthmus:report of a case 显示文摘 | Graceffa G Cipolla C Florena AM | 2013 | Surg Today2013，43，1： | 1 |
| 18 | Splenic marginal zone lymphoma显示文摘 | Franco V Florena AM Iannitto E | 2003 | Blood2003，101，7： | 1 |
| 19 | Immunophenotypical comparison of Gaucher′s and pseudo-Gaucher cells显示文摘 | Florena AM Franco V Campesi G | | 0，，02： | 1 |
| 20 | Splenic marginal zone lymphoma显示文摘 | Franco V Florena A m Iannitto E | 2003 | Blood2003，101，： | 1 |
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