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| 1 | Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the Middle East:a modified Delphi-based study显示文摘Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CMPA)in the Middle East.Methods A three-step modified Delphi method was utilized to develop the consensus.Fifteen specialized pediatricians participated in the development of this consensus.Each statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected CMPA.Formula-fed infants with confirmed CMPA should be offered a therapeutic formula.The panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag signs.At the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic reactions.The panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional status.On the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional status.In cases with no symptomatic improvements after the introduction of an AAF.other measures should be followed.The panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East. | Moustafa A.El-Hodhod Mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein AM Almehaidib Basil Nasrallah Ebtsam Mohammed AIBassam Hala El Feghali Hasan M.Isa Khaled Al Saraf Maroun Sokhn Mehdi Adeli Najwa Mohammed Mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi | 2021 | World Journal of Pediatrics2021，17，6： | 3 |
| 2 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | Peroxynitfite activates glucose uptake in 3T3-L1 adipocytes through a P13-K-dependent mechanism显示文摘 | Guzman-Grenfell AM Garcia-Macedo R Gonzalez-Martinez MT et al | 2005 | Front Biosci2005，10，1： | 1 |
| 4 | A thyrotropin-sereting pituitary adenoma as a cause of thyrotoxic periodic paralysis显示文摘 | Alings AM Fliers E de Herder WW | 1998 | J Endocrinol Invest1998，21，10： | 1 |
| 5 | Evidence for inflammation in asthma 显示文摘 | Hogg J CJ Ames AL Pate PD | 1991 | Am Rev Respir Dis1991，143，5： | 1 |
| 6 | Evalua- tion and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines 显示文摘 | Dogan AL Legrand O Faussat AM | 2004 | Leuk Res2004，28，6： | 1 |
| 7 | Improved gas exchange and survival after KL - 4 surfactant in newborn pigs with severe acute lung injury 显示文摘 | Zimmermann AM Roberts KD Lampland AL | 2010 | Pediatr Pulmonol2010，45，8： | 1 |
| 8 | Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling显示文摘 | Bauer B Hartz AM Pekcec A ei al | 2008 | Mol Pharmacol2008，73，： | 1 |
| 9 | Critical comparison of molecular genotyping methods for detection of drug-resistant Plasmodium falciparum显示文摘 | Ranford Cartwright LC Johnston KL Abdel-Muhsin AM et al | 2002 | Trans R Soc Trop Med Hyg2002，，5： | 1 |
| 10 | Leukocyte -mediated endothelial cell injury and death in the diabetic retina显示文摘 | Joussen AM Murata T Tsujikawa A ct al | 2001 | Am J Pathol2001，158，： | 1 |
| 11 | Helical CT for nephrolithiasis and ureterolithiasis: comparison of conventional and reduced radiation-dose techniques显示文摘 | Joan PH Keith AM Richard AL | 2003 | Radiology2003，229，11： | 1 |
| 12 | The prog'nosti value of PCNA(Proliferating cell nuclear antigen immunostaining in gastrointestinal lymphomas(abstract) 显示文摘 | Woods AL Hanby AM Hall PA | 1990 | J Pathol1990，161，3： | 1 |
| 13 | High expression of leptin by human bone marrow adipocytes in primary culture显示文摘 | Laharrague P Larrouy D Fontanilles AM at al | 1998 | FASEB1998，12，： | 1 |
| 14 | Potential interactions between alternative therapies and warfarin显示文摘 | Heck AM DeWitt BA Lukes AL | 2000 | Am J HealthSyst Pharm2000，57，13： | 1 |
| 15 | Bronchodilators for bronchiolitis 显示文摘 | QGadomski AM Bhasale AL | 2006 | Cochrane Database Syst Rev2006，，00： | 1 |
| 16 | Resveratrol inhibits proliferation, angiogenesis and induces apoptosis in colon cancer cells: Calorie restriction is the force to the cytotoxicity显示文摘 | Fouad MA Agha AM Merzabani MM Al Shouman SA | 2013 | Human and Experimental Toxicology2013，，10： | 1 |
| 17 | Mitral valve surgery for functional mitral regurgitation: should moderate-or-more tricuspid regurgitation be treated? a propensity score analysis显示文摘 | Calafiore AM Gallina S Iacb AL | 2009 | Ann Tho- rac Surg2009，87，3： | 1 |
| 18 | Casein peptide release and passage to the blood in humansduring digestion of milk and yogurt 显示文摘 | Chabance B Marteau P Rambaud J C et aL AM | 1998 | Biochimie1998，80，2： | 1 |
| 19 | An open-label study of memantine treatment in 3 subtypes of frontotemperal lobar degeneration 显示文摘 | Boxer AL Lipton AM Womack K | 2009 | Alzheimer Dis Assoc Disord2009，23，： | 1 |
| 20 | Clinical behavior of solitary fibrous tumors of the pleura显示文摘 | de Perrot M Kurt AM Robert JH el al | 1999 | Ann Thorac Surg1999，67，5： | 1 |
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