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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | The Rai ( She C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia显示文摘 | Flavia T Cinara E Alberto G | 2004 | Proc Natl Acad Sci U S A2004，101，15： | 1 |
| 3 | Body fat and insulin resist- ance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome 显示文摘 | Flavia T Romolo D Roberto C | 2009 | Eur J Endocrinol2009，161，5： | 1 |
| 4 | Evaluation of an adsorptionelution method for detection of astrovirus and norovirus in environmental waters显示文摘 | Matvias V Flavia G Fumian T | 2009 | J Virol Methods2009，156，2009： | 1 |
| 5 | Intelligent drug delivery systems obtained by radiation显示文摘 | Flavia M Olga Z H Erzsebet T | 1998 | Radiation Physical Chemistry1998，52，6： | 1 |
| 6 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 7 | Mobilization and r-ecovery of energy stores in trai′ra,Hoplias malabaricus bloch(Teleostei,Erythrinidae)during long-term starvation and after re-feeding显示文摘 | Flavia S R Gilberto M Eliane T O | 2006 | Comp Physiol B2006，176，： | 1 |
| 8 | Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adeno-virus,Ad5/F35显示文摘 | Flavia P Francesco T Tiziana P | 2006 | Clin Cancer Res2006，12，111： | 1 |
| 9 | Evaluation of an adsorptio-nelution method for detection of astro virus and norovirus in environ-mental waters显示文摘 | Matvias V Flavia G Fumian T | 2009 | J Virol Methods2009，156，12： | 1 |
| 10 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | The Lancet . 2013 (9908)2013，，： | 1 |
| 11 | IAPS includes photographs that elicit low - arousal physiological responses in healthy volunteers 显示文摘 | Rafaela L R Flavia T S Sabine P | 2007 | Physiology and Behavior2007，91，5： | 1 |
| 12 | Evaluation of maize core collection for drought tolerance 显示文摘 | Flavia F T Reinaldo L G Paulo E P | 2010 | Crop Breeding and Applied Biotechnology2010，10，： | 1 |
| 13 | Extraction of Bioacdve Amines from Grated Parmesan Cheese Using Acid, Alkaline and Organic Solvents 显示文摘 | FLAVIA B C eRICO T MARIA B A G | 2007 | Journal of Food Composition and Analysis2007，20，： | 1 |
| 14 | The neuron-specific rai (ShcC) adaptor protein inhibits apoptosis by coup'ling ret to the phosphatidylinositol 3-kinase Akt signaling pathway 显示文摘 | Giuliana P Flavia T Alessandra B | 2002 | Mol Cell Biol2002，22，20： | 1 |
| 15 | Chagas heart disease:An overview of diagnosis,manifestations,treatment,and care显示文摘Chagas heart disease(CHD)affects approximately 30%of patients chronically infected with the protozoa Trypanosoma cruzi.CHD is classified into four stages of increasing severity according to electrocardiographic,echocardiographic,and clinical criteria.CHD presents with a myriad of clinical manifestations,but its main complications are sudden cardiac death,heart failure,and stroke.Importantly,CHD has a higher incidence of sudden cardiac death and stroke than most other cardiopathies,and patients with CHD complicated by heart failure have a higher mortality than patients with heart failure caused by other etiologies.Among patients with CHD,approximately 90%of deaths can be attributed to complications of Chagas disease.Sudden cardiac death is the most common cause of death(55%–60%),followed by heart failure(25%–30%)and stroke(10%–15%).The high morbimortality and the unique characteristics of CHD demand an individualized approach according to the stage of the disease and associated complications the patient presents with.Therefore,the management of CHD is challenging,and in this review,we present the most updated available data to help clinicians and cardiologists in the care of these patients.We describe the clinical manifestations,diagnosis and classification criteria,risk stratification,and approach to the different clinical aspects of CHD using diagnostic tools and pharmacological and non-pharmacological treatments. | Roberto M Saraiva Mauro Felippe F Mediano Fernanda SNS Mendes Gilberto Marcelo Sperandio da Silva Henrique H Veloso Luiz Henrique C Sangenis Paula Simplício da Silva Flavia Mazzoli-Rocha Andréa S Sousa Marcelo T Holanda Alejandro M Hasslocher-Moreno | 2021 | World Journal of Cardiology2021，13，12： | 1 |
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