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| 1 | Comparisons between glucose analogue 2-deoxy-2-(^(18)F)fluoro-D-glucose and ^(18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions显示文摘AIM: To compare 2-deoxy-2-(^(18)F)fluoro-D-glucose(^(18)FFDG) and ^(18)F-sodium(^(18)F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent ^(18)F-FDG and ^(18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden's index. Mc Nemar's χ~2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding ^(18)F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to ^(18)F-Na F PET/CT findings. RESULTS: The two imaging methods of ^(18)F-FDG and ^(18)F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar's χ~2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar's χ~2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, ^(18)F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); ^(18)F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions(P < 0.04). ^(18)F-Na F PET/CT led to a change of management in 3 of the 45 patients(6.6%) by revealing findings that were not detected at ^(18)F-FDG PET/CT. CONCLUSION: ^(18)F-FDG PET/CT is a reliable imaging tool in the detection of bone metastasis in most cases, with a diagnostic accuracy that is slightly, but significantly, superior to that of ^(18)F-Na F PET/CT in the general population of breast cancer patients. However, the extremely high sensitivity of ^(18)F-fluoride PET/CT can exploit its diagnostic potential in specific clinical settings(i.e., small CT-evident sclerotic lesions, high clinical suspicious of relapse, and negative ^(18)F-FDG PET and conventional imaging). | Selene Capitanio Francesca Bongioanni Arnoldo Piccardo Claudio Campus Roberta Gonella Lucia Tixi Mehrdad Naseri Michele Pennone Vania Altrinetti Ambra Buschiazzo Irene Bossert Francesco Fiz Andrea Bruno Andrea DeCensi Gianmario Sambuceti Silvia Morbelli | 2016 | World Journal of Radiology2016，8，2： | 3 |
| 2 | Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk显示文摘AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F) uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS: Seventy-eight patients(44 females,mean age 63,range 44-83) underwent whole body 18F-Na F positron emission tomography/computed tomography. Cardiovascular risk(CVR) was used to divide these patients in three categories: Low(LR),medium(MR) and high risk(HR). 18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta.RESULTS: A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84 ± 0.76 vs 1.07 ± 0.3,P < 0.001),but also between MR and HR-LR(1.4 ± 0.4,P < 0.02 and P < 0.01,respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P < 0.01). Myocardial uptake provided an effective CVR classes stratification(P < 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R = 0.67),but it peaked when correlating the descending thoracic segment(R = 0.75),in comparison with the aortic arch and the ascending segment(R = 0.55 and 0.53,respectively). CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients' risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination. | Francesco Fiz Silvia Morbelli Matteo Bauckneht Arnoldo Piccardo Giulia Ferrarazzo Alberto Nieri Nathan Artom Manlio Cabria Cecilia Marini Marco Canepa Gianmario Sambuceti | 2016 | World Journal of Radiology2016，8，1： | 2 |
| 3 | The length of time healthy subjects and patients with chronic obstructive pulmonary disease are able to withstand maximal inspiratory pressure显示文摘 | Fiz JA Aguilar X Gallego M | | 0，，： | 1 |
| 4 | A randomized clinical trial evaluating plasmarich in growth factors(PRGF-Eiidoret) versus hyaluronic add in the short-termtreatment of symptomatic knee osteoarthritis 显示文摘 | Sanchez M Fiz N Azofra J | 2012 | Arthroscopy2012，28，8： | 1 |
| 5 | Continuous analysis and monito- ring of snores and their relationship to the apnea-hypopnea index 显示文摘 | Fiz JA Jane R Sola-Soler J | 2010 | Laryngoscope2010，120，4： | 1 |
| 6 | Effect of body position on lung sounds in healthy young men 显示文摘 | Fiz JA Gnitecki J Kraman SS | 2008 | Chest2008，133，3： | 1 |
| 7 | A randomized clinical trial e- factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee os- teoarthritis显示文摘 | Sanchez M Fiz N Azofra J et valuating plasma rich in growth al | 2012 | Arthroscopy2012，28，： | 1 |
| 8 | Sand-to-concrete interface response to complex load paths in a large displacement shear box显示文摘 | GOMEZ J E FIZ G M EBELING R M | 2008 | Geotechnical Testing Journal2008，31，4： | 1 |
| 9 | Arthroscopic management and platelet-rich plasma therapy for avascular necrosis of the hip显示文摘 | Guadilla J Fiz N Andia I | | 0，，02： | 1 |
| 10 | Further Results in the FastEstimation of a SingleFrequency显示文摘 | Fiz M P | 1994 | IEEE Transactions on Communications1994，42，234： | 1 |
| 11 | A less-invasive technique for capsular management during hip arthroscopy for femoroacetabular impingement显示文摘 | Fiz N Sánchez M Pérez JC | 2014 | Arthrosc Tech2014，3，4： | 1 |
| 12 | All night analy- sis of time interval between snores in subjects with sleep apnea hypopnea syndrome显示文摘 | MESQUITA J SOLh-SOLER J FIZ JA | 2012 | Med BiN Eng Comput2012，50，4： | 1 |
| 13 | nCPAP treat-ment interruption inOSA patients显示文摘 | Fiz JA Abad J Ruiz J | 1998 | Respir Med1998，92，1： | 1 |
| 14 | Effect of body position on lung sounds in healthy yong men显示文摘 | Fiz J A Gnitecki J Kraman S S | 2008 | Chest2008，133，3： | 1 |
| 15 | All night analysis of time inter-val between snores in subjects with sleep apnea hypopnea syndrome显示文摘 | Mesquita J Solà-Soler J Fiz JA | | 0，，： | 1 |
| 16 | Ultrasound-guided plateletrich plasma injections for the treatment of osteoarthritis of the hip显示文摘 | Sánchez M Guadilla J Fiz N | 2012 | Rheumatology(Oxford)2012，51，1： | 1 |
| 17 | Mixing analysis of nutrient, oxygen and dissolved inorganic carbon in the upper and middle North Atlantic Ocean east of the Azores 显示文摘 | Fiz F Perez Aida F Ryos Carmen G Castro | 1998 | Journal of Marine Systems1998，16，： | 1 |
| 18 | Effectof body position on lung sounds in healthy young men 显示文摘 | JoseAntonio Fiz January Gnitecki Steve S | 2008 | Chest2008，133，5： | 1 |
| 19 | Continuous analysis and monitoring of snores and their relationship to the apnea-hypopnea index显示文摘 | Fiz JA Jané R Solà-Soler J | | 0，，4： | 1 |
| 20 | Phylogenetic posi- tion of Mediterranean Astereae and character evo- lution of daisies (Be//is, Asteraceae) inferred from nrDNA ITS sequences 显示文摘 | Fiz O Valcarcel V Vargas P | 2002 | Mol Phyl Evol2002，25，： | 1 |
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