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| 1 | Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions显示文摘包括 osteoarticular 条件, tendinopathies,和肌肉损害,关于普通肌与骨的问题的当前的研究集中于再生翻译的药。充满血小板的血浆治疗作为一条潜在的途径出现了提高织物修理和新生。充满血小板的血浆申请试图提供血小板并且选择性地的 supraphysiological 集中在 injured/pathological 纸巾 mimicking 的白血球愈合的起始的阶段。然而,因为病人结果显示出部分改进,充满血小板的血浆的功效在长期的疾病是争论的。充满血小板的血浆能被选择最适当的明确的表达并且为申请或由把充满血小板的血浆与 synergistic 或互补治疗相结合预定设定到特定的条件。达到这个目标,研究人员们应该识别并且提高愈合的主要机制。在这评论,在充满血小板的血浆和愈合的机制之间的相互作用被探讨并且研究机会因为设定的治疗形式被构画出。combinational 的发展能安全地并且有效地被使用操作愈合的机制的充满血小板的血浆治疗将是珍贵的并且将提供卓见进涉及生理的愈合和病理学的失败的过程。 | Isabel Andia Michele Abate | 2018 | Frontiers of Medicine2018，12，2： | 7 |
| 2 | 一种新的备洞方法及其自体骨移植物制备的技术要点显示文摘目的介绍一种新的种植备洞系统,外科医师可以通过应用该系统,并配合使用富含生长因子的血浆(plasma rich in growth factors,PRGF),得到自体生活的骨组织来进行骨移植。材料和方法分别运用传统的和新的备洞系统收集10位患者的骨组织,并应用光镜和电镜来分析。另收集43名志愿者的血液样本,制备成为PRGF,定量分析其中所含的血小板数量、生长因子浓度(胰岛素生长因子1、转移生长因子1、血小板衍化生长因子-1、血管内皮生长因子、肝细胞生长因子以及内皮生长因子)。最后有一例病例报道。结果显微镜结果显示,使用低转速备洞方法获得的骨碎片,所有样本中的骨结构和细胞都被保留了下来。而使用传统方法获得的样本则没有如上特性。TGF-β(55.27±16.23ng/ml),PDGF—AB(27.96±12.13ng/m1),VEGF(421.09±399.0pg/ml),EGF(455.49±210.04pg/ml),HGF(605.70±269.20pg/ml)的平均值显示与血小板计数(590,000±197,000/μl;P〈.05)有显著相关性。讨论和结论新的备洞系统是以生物学标准为基础的。该方法可以减少对术区组织的损伤,并且可以获得新鲜的骨组织,联合应用富含生长因子的血浆能够在随后的骨组织移植中使用。该新方法具有能够促进骨组织愈合的可能性,但还需要在临床实验中进一步论证。 | Eduardo Anitua Carmen Carda Isabel Andia 吴茴(译) 林野(校) | 2007 | 中国口腔医学继续教育杂志2007，10，4： | 4 |
| 3 | Incidence and survival of stomach cancer in a high-risk population of Chile显示文摘AIM:To study the incidence and survival rate of stomach cancer(SC)and its associated factors in a high risk population in Chile. METHODS:The population-based cancer registry of Valdivia,included in the International Agency for Research on Cancer system,covers 356 396 residents of Valdivia Province,Southern Chile.We studied all SC cases entered in this Registry during 1998-2002 (529 cases).Population data came from the Chilean census(2002).Standardized incidence rates per 100 000 inhabitants(SIR)using the world population, cumulative risk of developing cancer before age 75, and rate ratios by sex,age,ethnicity and social factors were estimated.Relative survival(EdererⅡmethod) and age-standardized estimates(Brenner method) were calculated.Specific survival rates(Kaplan-Meier) were measured at 3 and 5 years and survival curves were analyzed with the Logrank and Breslow tests. Survival was studied in relation to demographics, clinical presentation,laboratory results and medical management of the cases.Those variables significantly associated with survival were later included in a Cox multivariate model. RESULTS:Between 1998 and 2002,529 primary gastric cancers occurred in Valdivia(crude incidence rate 29.2 per 100000 inhabitants).Most cases were male(69.0%), residents of urban areas(57.5%)and Hispanic(83.2%), with a low education level(84.5%<8 school years). SC SIR was higher in men than women(40.8 and 14.8 respectively,P<0.001),risk factors were low education RR 4.4(95%CI:2.9-6.8)and 1.6,(95%CI:1.1-2.1) for women and men respectively and Mapuche ethnicity only significant for women(RR 2.2,95%CI:1.2-3.7).Of all cases,76.4%were histologically confirmed,11.5% had a death certificate only(DCO),56.1%were TNM stageⅣ;445 cases(84.1%)were eligible for survival analysis,all completed five years follow-up;42 remained alive,392 died of SC and 11 died from other causes. Specific 5-year survival,excluding cases with DCO,was 10.6%(95%CI:7.7-13.5);5-year relative survival rate was 12.3%(95%CI:9.1-16.1),men 10.9%(95%CI: 7.4-15.2)and women 16.1%(95%CI:9.5-24.5).Fiveyear specific survival was higher for patients aged<55 years(17.3%),with intestinal type of cancer(14.6%), without metastasis(22.2%),tumor size<4 cm(60.0%), without lymphatic invasion(77.1%),only involvement of the mucous membrane(100%).Statistically significant independent prognostic factors were:TNM staging, diffuse type,metastasis,supraclavicular adenopathy, palpable tumor,and hepatitis or ascites. CONCLUSION:Social determinants are the main risk factors for SC,but not for survival.An advanced clinical stage at consultation is the main cause of poor SC survival. | Katy Heise Enriqueta Bertran Marcelo E Andia Catterina Ferreccio | 2009 | World Journal of Gastroenterology2009，15，15： | 2 |
| 4 | Dual-phase helical CT of pancreatic adenocarcinoma: assessment of resectability before surgery 显示文摘 | Vails C Andia E Sanchez A | 2002 | A JR Am J Roentgenol2002，178，4： | 1 |
| 5 | Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in cul- ture 显示文摘 | Anitua E Andia I Sanchez M | 2005 | J Orthop Res2005，23，2： | 1 |
| 6 | Dual-phase helical CT of pancreatic adenocarcinoma:assessment of resectability before surgery显示文摘 | Valls C Andia E Sanchez A | 2002 | AJR2002，178，4： | 1 |
| 7 | Biochemical evalua-tion of glycemic levels of long-term tacrolimus therapy in rats显示文摘 | Nassar CA Nassar PO Andia DC | 2007 | Braz Oral Res2007，21，4： | 1 |
| 8 | Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF pro- duction by human tendon cells in culture 显示文摘 | Anitua E Andia I Sanchez M | 2005 | Journal of Orthopaedic Research2005，23，2： | 1 |
| 9 | Use of platelet - rich plasma for patellar ten- don and medial collateral ligament injuries: best current clinical practice显示文摘 | Andia I Maffulli N | 2015 | JKneeSurg2015，28，1： | 1 |
| 10 | Arthroscopic management and platelet-rich plasma therapy for avascular necrosis of the hip显示文摘 | Guadilla J Fiz N Andia I | | 0，，02： | 1 |
| 11 | Long-term evolution and outcomes of microprolactinoma with medical treatment 显示文摘 | Martin de Santa-Olalla y Llanes M Andia Melero VM Jara Albarr6n A | 2013 | Endocrinol Nutr2013，60，9： | 1 |
| 12 | Dual-phase helical CT of pan-creatic adenocarcinoma:assessment of resectability before surgery显示文摘 | Vails C Andia E Sanchez A | 2002 | AJR Am J Roentgenol2002，178，4： | 1 |
| 13 | Bone metabolism,vascular calcifications and rnortality: associations beyond mere coincidence 显示文摘 | Rodriguez Garcia M Naves Diaz M Cannata Andia JB | 2005 | J Nephrol2005，18，4： | 1 |
| 14 | Hepatic metastases from colorectal cancer:preoperative detection and assessment of resectability with helical CT显示文摘 | Valls C Andia E Sanchez A | 2001 | Radiology2001，218，1： | 1 |
| 15 | Use of platelet-rich plasma for patellar tendon and medial collateral ligament injuries: best current clinical prac- tice显示文摘 | Andia I Maffulli N | 2015 | J Knee Surg2015，28，1： | 1 |
| 16 | CT in hepatic cirrhosis and chronic hepatitis显示文摘 | Valls C Andia E Roca Y | 2002 | Seminsrs in Ultrasound CT and MRI2002，23，： | 1 |
| 17 | CT in hepatic cirrhosis and chronic hepatitis 显示文摘 | Valls C Andia E Roca Y etal | 2002 | Semin Ultrasound CT MR2002，223，1： | 1 |
| 18 | The potential impact of the preparation fichin growth factors (PRGF) in different medical fields 显示文摘 | ANITUA E SaNCHEZ M ORIVE G ANDIA | 2007 | BIO- MATERIALS2007，28，31： | 1 |
| 19 | Preganacy outcome in patients treated with cervical conization for cervical intraepithelial neoplasis显示文摘 | Andia D Mozo de Rosales F Villasante A | 2011 | Int J Gynaecol Obstet2011，112，3： | 1 |
| 20 | Fibrin-targeted magnetic resonance imaging allows in vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis显示文摘 | Andia ME Saha P Jenkins J | 2014 | Arterioscler Thromb Vasc Biol2014，34，6： | 1 |
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