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| 1 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Effect of dilution methane entering an SOFC anode显示文摘 | Kdendall K Finnerty C M Sauunders G | 2002 | J Power Sources2002，106，1： | 1 |
| 3 | Carbon formation on and deactivation of nickel-based/zirconia anodes in solid oxide fuel cells running on methane 显示文摘 | Finnerty C M Coe N J Cunningham R H | 1998 | Catalysis Today1998，46，2： | 1 |
| 4 | Process measures for the assessment and improvement of quality of care for schizophrenia显示文摘 | Hermann RC Finnerty M Provost S | 2002 | Schizophr Bull2002，28，1： | 1 |
| 5 | Severe injury is associat-ed with insulin resistance, endoplasmic reticulum stressresponse,and unfolded protein response显示文摘 | Jeschke M G’Finnerty C C Herndon D N Song J Boe-hning D Tompkins R G | 2012 | Ann Surg2012，255，： | 1 |
| 6 | Challenges for psychiatry in serving homeless people with psychiatric disorders显示文摘 | McQuistion HL Finnerty M Hirschowitz J | 2003 | Psychiatr Serv2003，54，5： | 1 |
| 7 | Effect of dilution methane entering an SOFC anode显示文摘 | KDENDALL K FINNERTY C M SAUUNDERS G CHUNG J T | 2002 | J Power Sources2002，106，12： | 1 |
| 8 | Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA显示文摘 | Pasquinelli A E Reinhart B J Slack F Martindale M Q Kuroda M I Maller B Hayward D C Ball E E Degnan B Müller P Spring J Srinivasan A Fishman M Finnerty J Corbo J Levine M Leahy P Davidson E and Ruvkun G | 2000 | Nature2000，408，6808： | 1 |
| 9 | Conservation of the sequence and temporal expression of let-7 heterochronie regulatory RNA 显示文摘 | Pasquinelli AE Reinhart BJ Slack F Martindale MQ Kuroda MI Mallet B Hayward DC Ball EE Degnan B Miiller P Spring J Srinivasan A Fishman M Finnerty J Corbo J Levine M Leahy P Davidson E Ruvkun G | 2000 | Nature2000，408，6808： | 1 |
| 10 | Age differences in inflammatory and hypermetabolic postburn responses 显示文摘 | Jeschke M G Norbury W B Finnerty C C | 2008 | Pediatrics2008，121，3： | 1 |
| 11 | The insect immune protein scolexin is a novel serine proteinase homolog 显示文摘 | Finnerty C M Karplus P A Granados R R | 1999 | Protein Science1999，8，1： | 1 |
| 12 | Microbial biosurfactant - physiology, biochemistry and applications 显示文摘 | Finnerty W R Singer M E | 1985 | Dev Ind Microbiol1985，25，： | 1 |
| 13 | The pathophysiologic response to severe bum injury 显示文摘 | Jeschke M Chinkes D Finnerty CC | 2008 | Ann Surg2008，248，3： | 1 |
| 14 | Space-time scale sensitivity of the Sacramento model to radar-gage precipitation inputs显示文摘 | FINNERTY B D SMITH M B SEO D J | 1997 | Journal of Hydrology1997，203，14： | 1 |
| 15 | Molecular Orbital Theory calculations of the H2O-carbon reaction显示文摘 | ZHU Z H FINNERTY J LU G Q WILSON M A YANG R T | | 0，，04： | 1 |
| 16 | Carbon formation on and deactivation ofnickel-based-zirconia anodes in solid fuel cells runningon methane显示文摘 | FINNERTY C M COE N J CUMNINGHAM RH | 1998 | Catalysis Today1998，46，23： | 1 |
| 17 | Intrathecal baclofen pump in fection treated by adjunct intrareservoir antibiotic installation显示文摘 | Samuel M Finnerty GT Rudge P | 1994 | J Neurol Neurosurg Psychiatry1994，57，9： | 1 |
| 18 | Immunization of bull calves with a GnRH analogue-human serum albumin conjugate: effect of conjugate dose,type of adjuvant and booster interval on immune, endocrine,testicular and growth responses显示文摘 | Finnerty M Enright W J Morrison C A | | J Reprod0，，： | 1 |
| 19 | The structure and composition of liposomes can affect akin regeneration, morphology and growth factor expression in acute wounds显示文摘 | JESCHKE M G SANDMANN G FINNERTY C C | 2005 | Gene Ther2005，12，23： | 1 |
| 20 | Space-time scale sensitivity of the Sacramento model to radar-gage precipita-tion inputs显示文摘 | Finnerty B D Smith M B Seo D J | | 0，，01： | 1 |
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