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| 1 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction显示文摘 | Longxiang Su Lin Feng Qing Song Hongjun Kang Xingang Zhang Zhixin Liang Yanhong Jia Dan Feng Changting Liu Lixin Xie Celeste C. Finnerty | 2013 | Mediators of Inflammation2013，，： | 2 |
| 3 | Dexmedetomidine Inhibits Inflammatory Reaction in Lung Tissues of Septic Rats by Suppressing TLR4/NF- κ B Pathway显示文摘 | Yuqing Wu Yingchun Liu He Huang Yangzi Zhu Yong Zhang Fuzhao Lu Ce Zhou Li Huang Xin Li Chenghua Zhou Celeste C. Finnerty | 2013 | Mediators of Inflammation2013，，： | 2 |
| 4 | A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkdl显示文摘 | Starremans PG Li X Finnerty PE | 2008 | Kidney Int2008，73，12： | 1 |
| 5 | SOFC system with intergrated catalytic fuel procession显示文摘 | Finnerty C Tompsett G A Kendall K | 2000 | Journal of Power Sources2000，86，1： | 1 |
| 6 | The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results显示文摘 | Finnerty Jp Lee C | 1995 | Eur Respir J1995，8，5： | 1 |
| 7 | Financial in Corporate Finance:An Overview显示文摘 | | 1998 | Financial Management1998，，： | 1 |
| 8 | Cytokineexpression prole over time in burned mice显示文摘 | Finnerty CC Przkora R Herndon DN | 2009 | Cytokine2009，45，1： | 1 |
| 9 | Challenges for psy-chiatry in serving homeless people with psychiatric disorders 显示文摘 | Mcquistion HL Finnerty Hisrchowitz J | 2003 | Psychiatric Services2003，54，： | 1 |
| 10 | Burn size determines the inflammatory and hypermetabolic response 显示文摘 | Jeschke MG Mlcak RP Finnerty CC | 2007 | Crit Care2007，11，4： | 1 |
| 11 | The miR - 15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases显示文摘 | FINNERTY J R WANG W X HI'BERT S S | 2010 | J Mol Biol2010，402，3： | 1 |
| 12 | Pathophysiologie re- sponse to severe burn injury显示文摘 | Jesehke MG Chinkes DL Finnerty CC | 2008 | Ann Surg2008，248，3： | 1 |
| 13 | Ipsilateral transversus abdominis plane block provides effective analgesia after appendectomy in children:A randomized controlled trial显示文摘 | Carney J Finnerty O Rauf J | 2010 | Anesth Analg2010，111，4： | 1 |
| 14 | Severe Injury Is Associated With Insulin Resistance, Endoplasmic Reticulum Stress Response, and Unfolded Protein Response显示文摘 | Marc G. Jeschke Celeste C. Finnerty David N. Herndon Juquan Song Darren Boehning Ronald G. Tompkins Henry V. Baker Gerd G. Gauglitz | 2012 | Annals of Surgery2012，，2： | 1 |
| 15 | Insiders and market efficiency显示文摘 | Finnerty Joseph E | 1976 | The Journal of Finance1976，31，4： | 1 |
| 16 | Insulin attenuates the cytokine response in a burn wound infection model 显示文摘 | Przkora R Herndon DN Finnerty CC | 2007 | Shock2007，27，2： | 1 |
| 17 | Temporal cytokine profiles in severely burned patients: a comparison of adults and children显示文摘 | Finnerty CC Jeschke MG Herndon DN | 2008 | Mol Med2008，14，910： | 1 |
| 18 | Burn size determines the inflammatory and hypermetabolic response 显示文摘 | Jeschke MG Mlcak RP Finnerty CC | 2007 | Crit Care2007，11，4： | 1 |
| 19 | Are serum cyto- kines early predictors for the outcome of burn patients with inha- lation injuries who do not survive? 显示文摘 | Gauglitz GG Finnerty CC Herndon DN | 2008 | Crit Care2008，12，3： | 1 |
| 20 | The surgically induced stress response显示文摘 | Finnerty CC Mabvuure NT Ali A | 2013 | JPEN J Parenter Enteral Nutr2013，37，5： | 1 |
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