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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Prevalence of unsuspected thyroid nodules in adults on contrast enhanced 16-and 64-MDCT of the chest显示文摘AIM: To determine the prevalence of unsuspected thyroid nodules on contrast enhanced 16and 64-modified discrete cosine transform (MDCT) of the chest, in a population of adult outpatients imaged for indications other than thyroid disease. METHODS: This retrospective study involved review of intravascular contrast-enhanced MDCT scans of the chest from 3077 consecutive adult outpatients, to identify unsuspected thyroid nodules. Exclusion criteria included history of thyroid cancer, known thyroid nodules or thyroid disease and risk factors for thyroid cancer, as evidenced by their medical records. One of 9 radiologists recorded number of nodules, location and bidirectional measurement of largest nodule, as well as amount of thyroid visualized on the chest computed tomography (CT). Presence of nodule was correlated with age, gender, race and percentage of thyroid imaged. RESULTS: A total of 2510 (2510/3077 or 81.6%) study subjects were included in the data analysis; among them,one or more nodules were identified in 629 subjects (629/2510 or 25.1%), with 242 (242/629 or 38.5%) having multiple nodules. Patients with nodule(s) were significantly older than those without (64 ± 13 years vs 58 ± 14 years, P < 0.0001), and female gender was associated with presence of nodule(s) (373/1222 or 30.5% vs 256/1288 or 19.9%, P < 0.0001). Women were also more likely having multiple nodules (167/373 or 44.8%) compared to men (75/256 or 29.3%, P < 0.0001). The majority of nodules (427/629 or 67.9%) were less than 1 cm. CONCLUSION: This retrospective review revealed a prevalence of 25.1% for unsuspected thyroid nodules on contrast-enhanced chest CT. | Sameer Ahmed Pamela T Johnson Karen M Horton Atif Zaheer Saline Tsai Elliot K Fishman | 2012 | World Journal of Radiology2012，4，7： | 4 |
| 3 | Impact of pediatric inflammatory bowel disease diagnosis on exercise and sports participation: Patient and parent perspectives显示文摘BACKGROUND Inflammatory bowel disease(IBD)may limit physical activity due to intestinal or extraintestinal manifestations,fatigue,or exercise perception.We sought to evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.We compared patient-reported and parent-reported perspectives.AIM To evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.METHODS Consecutive IBD outpatients(aged 10-18 years)and their parents completed parallel voluntary surveys.A validated,patient-reported functional activity scale,the Hospital for Special Surgery Pediatric Functional Activity Brief Scale(HSS Pedi-FABS)was used to assess children’s activity levels.RESULTS There were 149 completed surveys(75%response rate)with mean participant age of 16.5 years[standard deviation(SD)=4.0]and mean age at IBD diagnosis of 11.8 years(SD=3.4).Most patients(77%)were diagnosed within 12 mo of symptom onset.Current athletic participation was reported in 65%across 65 sports.Participation was greatest before(40%)rather than after(32%)IBD diagnosis,with no reported change in 28%.IBD negatively impacted play/performance in 45%but did not change play/performance in 44%.IBD treatment improved patients’desire to exercise(70%)and subjective capacity for aerobic exercise(72%).Patients and parents agreed that IBD subjects demonstrate normal capacity for aerobic exercise(0.40,95%CI:0.22-0.58)and that treatment improved both participatory desire(0.33,95%CI:0.12-0.54)and capacity for aerobic exercise(0.52,95%CI:0.31-0.71).Almost all(99%)viewed exercise as healthy,and most encouraged its practice.IBD patients demonstrated normal mean HSS Pedi-FABS scores.CONCLUSION After pediatric IBD diagnosis,most patients continue exercise and sports,with mean activity levels comparable to American youth.Treatment positively impacts participatory desire and aerobic capacity.Patients favor the role of exercise in IBD. | Renée M Marchioni Beery Enju Li Laurie N Fishman | 2019 | World Journal of Gastroenterology2019，25，31： | 2 |
| 4 | Role of computed tomography angiography in detection and staging of small bowel carcinoid tumors显示文摘Small-bowel carcinoid tumors are the most common form(42%) of gastrointestinal carcinoids, which by themselves comprise 70% of neuroendocrine tumors. Although primary small bowel neoplasms are overall rare(3%-6% of all gastrointestinal neoplasms), carcinoids still represent the second most common(20%-30%) primary small-bowel malignancy after small bowel adenocarcinoma. Their imaging evaluation is often challenging. State-of-the-art high-resolution multiphasic computed tomography together with advanced postprocessing methods provides an excellent tool for their depiction. The manifold interactive parameter choices however require knowledge of when to use which technique. Here, we discuss the imaging appearance and evaluation of duodenal, jejunal and ileal carcinoid tumors, including the imaging features of the primary tumor, locoregional mesenteric nodal metastases, and distant metastatic disease. A protocol for optimal lesion detection is presented, including the use of computed tomography enterography, volume acquisition, computed tomography angiography and three-dimensional mapping. Imaging findings are illustrated with a series of challenging cases which illustrate the spectrum of possible disease in the small bowel and mesentery, the range of possible appearances in the bowel itself on multiphase data and extraluminal findings such as the desmoplastic reaction in mesentery and hypervascular liver metastases. Typical imaging pitfalls and pearls are illustrated. | David Bonekamp Siva P Raman Karen M Horton Elliot K Fishman | 2015 | World Journal of Radiology2015，7，9： | 2 |
| 5 | The value of transvaginal sonography in the preoperative assessment of myometrial invasion in high and low grade endometrial cancer and in comparison to frozen section in grade 1disease 显示文摘 | Altaras M Bernheim J | 2000 | Eur J Gynaecol Oncol2000，21，： | 1 |
| 6 | The value of transvaginal sonography in the preoperative assessment of myomeyrial invasion in high and lowgrade endometrial cancer and in comparison to frozen section in grade 1 disease显示文摘 | Fishman A Altaras M Bemheim j | 2000 | Eur j Gynaecol Oneo2000，21，1： | 1 |
| 7 | Physical and mechanical proper-ties of highly plasticized pectin/starch films显示文摘 | Coffin D R Fishman M L | 1994 | J Appl Polym Sci1994，54，9： | 1 |
| 8 | Adrenal imaging with MDCT: nonneoplastic disease 显示文摘 | Johnson P T Horton K M Fishman E K | 2009 | A JR2009，193，4： | 1 |
| 9 | Mechanism of all-trans rednoic acid effect on tumor-associ-ated myeloid-derived suppressor cells 显示文摘 | NEFEDOVA Y FISHMAN M SHERMAN S’ | 2007 | Cancer Res2007，67，11： | 1 |
| 10 | A novel tryptase inhibitor, APC 366, inhibits allergeninduced airway and inflammatory responses in allergic sheep 显示文摘 | Clark J M Moore W R Fishman C E | 1995 | Am J Respir Crit Care Med1995，152，6： | 1 |
| 11 | Nitric oxide inhibits alpha 2-adrenoceptor-mediated endothelium- dependent vasodilation 显示文摘 | THORIN E HUANG P L FISHMAN M C | 1998 | Circ Res1998，82，12： | 1 |
| 12 | L-canavanine improves organ function and tissue adenosine triphosphate levels in rodent endotoxemia显示文摘 | Fishman D Markert M | 1997 | Am J Respir Crit Care Med1997，155，5： | 1 |
| 13 | the natural history of renal angiomyolipoma显示文摘 | Steiner M S Uollnan S M Fishman E K | 1993 | J urol1993，150，： | 1 |
| 14 | Combination antiviral therapy for ganciclovir-resistant cytomegalovirus infection in solidorgan transplant recipients显示文摘 | MYLONAKIS E KALLAS W M FISHMAN J A | 2002 | Clin Infect Dis2002，34，： | 1 |
| 15 | Macromolecular components of tomato fruit pectin显示文摘 | Fishman M L Gross K C Gillespie D T | 1989 | Arch Biochem Biophys1989，274，： | 1 |
| 16 | Pathogenesis in acute aortic syndromes: aortic aneurysm leak and rupture and traumatic aortic transection 显示文摘 | MACURA J K CORL F M FISHMAN E K | 2003 | Am J Roentgenol2003，181，： | 1 |
| 17 | Mag-neto-optical readout of dark exciton distribution in cuprousoxide显示文摘 | FISHMAN D FAUGERAS C POTEMSKI M | 2009 | Physical Review:B2009，80，4： | 1 |
| 18 | Aortic valve calcification in systemic lupus erythematosus显示文摘 | Kiani AN Fishman EK Petri M | 2006 | Lupus2006，15，12： | 1 |
| 19 | Laser produced functionally graded tungsten carbide coatings on M2 high-speed tool steel显示文摘 | Riabkina Fishman M Rabkin E Levin P | 2001 | Materials Science and Engineering A2001，302，1： | 1 |
| 20 | Successful carboplatin desensitization in patients with proven carboplatin al- lergy显示文摘 | CONFINO C FISHMAN A ALTARAS M | 2005 | Cancer2005，104，3： | 1 |
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