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| 1 | Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients. | QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 2 | Sensory and affective pain discrimination after inhalation of essential oils显示文摘 | Gedney JJ Glover TL Fillingim RB | 2004 | Psychosom Med2004，66，4： | 1 |
| 3 | The AllSG singlenucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans显示文摘 | Fillingim RB Kaplan L Staud R | 2005 | JPain2005，6，3： | 1 |
| 4 | Morphine responses and experimental pain:sex differences in side effects and cardiovascular responses but not analgesia显示文摘 | Fillingim RB Ness TJ Glover TL | 2005 | J Pain2005，6，2： | 1 |
| 5 | Individual Differences in Morphine and Butorphanol Analgesia: A Laboratory Pain Study显示文摘 | Kimberly T. Sibille Lindsay L. Kindler Toni L. Glover Ricardo D. Gonzalez Roland Staud Joseph L. Riley Roger B. Fillingim | 2011 | Pain Medicine2011，，7： | 1 |
| 6 | Sex differences in opioid analgesia: clinical and experimental findings显示文摘 | Fillingim RB Gear RW | 2004 | EurJ Pain2004，8，5： | 1 |
| 7 | Sex, gender, and pain: a review of recent clinical and experi- mental findings显示文摘 | FILLINGIM RB KING CD RIBEIRO-DASILVA MC | 2009 | J Pain2009，10，5： | 1 |
| 8 | Individual differences in pain responses 显示文摘 | Fillingim RB | 2005 | Curr Rheumatol Rep2005，7，5： | 1 |
| 9 | Sex differences in the incidence of severe pain events following surgery:a review of333,000 pain scores显示文摘 | Tighe PJ Riley JL 3rd Fillingim RB | 2014 | Pain Med2014，15，8： | 1 |
| 10 | Left vagus nerve stimulation suppresses experimentally induced pain显示文摘 | Ness T Randich A Fillingim R | 2001 | Neurology2001，56，7： | 1 |
| 11 | Experimental pain models reveal no sex differences in pentazocine analgesia in humans显示文摘 | FILLINGIM R B NESS T J GLOVER T L | 2004 | Anesthesiology2004，100，5： | 1 |
| 12 | Metallictaste phantom predicts oral pain among 5-year survivorsof head and neck cancer显示文摘 | Logan HL Bartoshuk LM Fillingim RB | 2008 | Pain2008，140，2： | 1 |
| 13 | Morphine responses and experimental pain: sex differences in side effects and cardiovascular responses but not analgesia 显示文摘 | Fillingim RB Ncss TJ Glover TL | 2005 | J Pain2005，6，2： | 1 |
| 14 | Psychologi-cal factors associated with development of TMD: The OP-PERA prospective cohort study 显示文摘 | Fillingim RB Ohrbach R Greenspan JD | 2013 | J Pain2013，14，12： | 1 |
| 15 | Morphine responses and experimental pain:sex differences in side effects and cardiovascular responses but not analgesia显示文摘 | Fillingim RB Ness TJ Glover TL | | 0，，02： | 1 |
| 16 | Sex,gender,and pain:a review of recent clinical and experimental findings显示文摘 | Fillingim RB King CD Ribeiro-Dasilva MC | 2009 | J Pain2009，10，5： | 1 |
| 17 | Feal of pain influences out- comes after exercise - induced delayed onset muscle 80renes $ at the shoulder显示文摘 | George SZ Dover GC Fillingim RB | 2007 | Clin J Pain2007，23，1： | 1 |
| 18 | The relationship of sex and clinical pain to experimental pain responses显示文摘 | Fillingim RB Edwards RR Powell T | 1999 | Pain1999，83，3： | 1 |
| 19 | Quantitative assessment of experimental pain perception: multiple domains of clinical relevance显示文摘 | Robert R. Edwards Eleni Sarlani Ursula Wesselmann Roger B. Fillingim | 2005 | Pain2005，，3： | 1 |
| 20 | Sexual and physical abuse history in subjects with temporomandibular disorders: relationship to clinical variables, pain sensitivity, and psychologic factors 显示文摘 | Fillingim RB Maixner W Sigurdsson A | 1997 | J Orofac Pain1997，11，1： | 1 |
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