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| 1 | Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury显示文摘Axonal regeneration and fiber regrowth is limited in the adult central nervous system, but research over the last decades has revealed a high intrinsic capacity of brain and spinal cord circuits to adapt and reorganize after smaller injuries or denervation. Short-distance fiber growth and synaptic rewiring was found in cortex, brain stem and spinal cord and could be associated with restoration of sensorimotor functions that were impaired by the injury. Such processes of structural plasticity were initially observed in the corticospinal system following spinal cord injury or stroke, but recent studies showed an equally high potential for structural and functional reorganization in reticulospinal, rubrospinal or propriospinal projections. Here we review the lesion-induced plastic changes in the propriospinal pathways, and we argue that they represent a key mechanism triggering sensorimotor recovery upon incomplete spinal cord injury. The formation or strengthening of spinal detour pathways bypassing supraspinal commands around the lesion site to the denervated spinal cord were identified as prominent neural substrate inducing substantial motor recovery in different species from mice to primates. Indications for the existence of propriospinal bypasses were also found in humans after cortical stroke. It is mandatory for current research to dissect the biological mechanisms underlying spinal circuit remodeling and to investigate how these processes can be stimulated in an optimal way by therapeutic interventions(e.g., fiber-growth enhancing interventions, rehabilitation). This knowledge will clear the way for the development of novel strategies targeting the remarkable plastic potential of propriospinal circuits to maximize functional recovery after spinal cord injury. | Linard Filli Martin E.Schwab | 2015 | Neural Regeneration Research2015，10，4： | 9 |
| 2 | 葛根素对心肌细胞一氧化氮影响的研究显示文摘目的研究葛根素对心肌细胞H9C2一氧化氮的影响。方法eNOS蛋白用Westernblot方法检测,eNOS基因用RT-PCR方法检测,并测定一氧化氮含量。结果在葛根素2mg/ml浓度下作用24h,可明显提高心肌细胞H9C2eNOS蛋白和基因表达。结论葛根素在心血管方面的保护作用很可能与调节一氧化氮含量及其合酶表达有关。 | 温葭 陈士林 Filly Cheung 郝雪娜 | 2006 | 中国心血管病研究2006，4，10： | 3 |
| 3 | Persistent intrahepatic right umbilical vein:a prenatal sonographic series without significant anomalies显示文摘 | Kirsch CF Feldstein VA Goldstein RB Filly RA | 1996 | J Ultrasound Med1996，15，： | 1 |
| 4 | Breast cancer detection with sonograpby and mammography: comparison using state-of-the-art equipment 显示文摘 | Sickles EA Filly RA Callen PW | 1983 | AJR Am J Roentgenol1983，140，5： | 1 |
| 5 | Vascular basis of mucosal color显示文摘 | Kleirtheinz J Buchter A Fillies T Joos U | 2005 | Head Face Med2005，1，： | 1 |
| 6 | Choroid plexus cyst and echogenic intracardiac focus in women at low risk for chromosomal anomalies 显示文摘 | Filly RA Benacerraf BR Nyberg DA Hobbins JC | 2004 | J Ultrasound Med2004，23，： | 1 |
| 7 | Obstetrical Magnetic Resonance Imaging:Fetal Anatomy显示文摘 | McCarthy SM Filly RA Stark DD | 1985 | Radiology1985，154，2： | 1 |
| 8 | Congenital vertebral malformations Prenatal diagnosis using ultrasonography显示文摘 | Abrams Sir Filly RA | 1985 | Radiology1985，155，： | 1 |
| 9 | Fetal surgery for congenital hydronephrosis显示文摘 | Harrison MR Golbus MS Filly RA | 1982 | N Engl J Med1982，306，： | 1 |
| 10 | HIFl-alpha overexpression indicates a good prognosis in early stage squa- mous cell carcinomas of the oral floor显示文摘 | Fillies T Werkmeister R van Diest PJ | 2005 | BMC Cancer2005，5，1： | 1 |
| 11 | Early tissue reaction at the interface of immediately loaded dental implants 显示文摘 | Meyer U Wiesmann HP Fillies T | 2003 | Int J Oral Maxillofac Implants2003，18，4： | 1 |
| 12 | HIFl-alpha overexpression indicates a good prognosis in early stage squa- mous cell carcinomas of the oral floor显示文摘 | Fillies T Werkmeister R van Diest PJ | 2005 | BMC Cancer2005，5，1： | 1 |
| 13 | The fetal costume magna 显示文摘 | Mahoney BS Callen PW Filly RA | 1984 | Radiology1984，153，3： | 1 |
| 14 | Paradoxical movements of abdominal contents indicating a congenital diaphragmatic hemia显示文摘 | Sista AK Filly RA | 2008 | J Ultrasound Med2008，27，3： | 1 |
| 15 | The fetal cistema magna显示文摘 | Mahony B Callen PW Filly RA | 1984 | Radiology1984，153，： | 1 |
| 16 | Complex fetal disor ders: effect of MR imaging on management--preliminary clini- cal experience显示文摘 | Coakley F V Hricak H Filly RA | 1999 | Radiology1999，213，3： | 1 |
| 17 | Sonographic predictorsof survival in fetal diaphragmatic hernia显示文摘 | Metkus AP Filly RA Stringer MD | 1996 | J Pediatr Surg1996，31，： | 1 |
| 18 | Obstetrical magnetic resonance imaging:fetal anatomy显示文摘 | McCarthy SM Filly RA Stark DD | 1985 | Radiology1985，89，1： | 1 |
| 19 | Early tissue reaction at the interface of immediately loaded dental implants显示文摘 | Meyer U Wiesmann HP Fillies T | | 0，，04： | 1 |
| 20 | High-resolution sonographic assessment of thefetal extremities显示文摘 | Mahony BS Filly RA | | 0，，11： | 1 |
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