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| 1 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 2 | Laparoscopic fenestration of multiple giant biliary mucinous cystadenomas of the liver显示文摘Biliary cystadenomas of the liver are rare, cystic neoplasms of the biliary ductal system usually occur in middle aged women. We report a case of synchronous multiple huge biliary mucinous cystadenomas with unique features. This is, according to our knowledge, the first report in the literature about three synchronously occurring hepatobiliary cystadenomas. Cystadenomas have a strong tendency to recur, particularly following incomplete excision, and a potential of malignant transformation. A therapeutic re-evaluation may be necessary when the diagnosis of hepatobiliary cystadenoma is made after the operation and an open liver resection should be considered. | A Manours E Lagoudianakis L Alevizos H Markogiannakis G Kafiri C Bramis K Filis K Toutouzas | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
| 3 | Malignant gastrointestinal melanomas of unknown origin: Should it be considered primary?显示文摘TO THE EDITOR We read with interest the article entitled: ‘Jejuno-jejunal invagination due to intestinal melanoma’ by Resta G, et al[1]. They reported a rare clinical case of a young woman with a bleeding jejunal melanoma, whose early | A Manouras M Genetzakis E Lagoudianakis H Markogiannakis A Papadima G Kafiri K Filis PB Kekis V Katergiannakis | 2007 | World Journal of Gastroenterology2007，13，29： | 2 |
| 4 | 14xy InGaAsP/InP ridge waveguide pump laser diodes with low vertical farfield and high efficiency显示文摘 | LICHTENSTEIN N FILY A HERMENS C | 2003 | OFC2003，1，： | 1 |
| 5 | Controversial issues in kyphoplasty and vertebroplasty in osteoporotic vertebral fractures 显示文摘 | Papanastassiou I D Filis A Gerochfistou M A | 2014 | Biomed Res Int2014，2014，93： | 1 |
| 6 | The prevalence of trig gets in paediatric migraine: a questionnaire study in 102 children and adolescents显示文摘 | Neut D Fily A Cuvellier JC | 2012 | Headache Pain2012，13，1： | 1 |
| 7 | Trigem-ino-cardiac reflex during transsphenoidal surgery forpituitary adenomas:methodological description of aprospective skull base study protocol显示文摘 | SCHALLER B J WEIGEL D FILIS A | 2007 | Brain Res2007，1149，： | 1 |
| 8 | High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphoma at risk for central nervous system involvement: the role of flow cy tometry versus cytology显示文摘 | Hegde U Filie A Lttle RF | 2005 | Blood2005，105，： | 1 |
| 9 | Muscle regeneration : cellular and molecular events 显示文摘 | Karalaki M Fili S Philippou A | 2009 | In Vivo2009，23，5： | 1 |
| 10 | The tall cell variant of papillary carcinoma of the thyroid : Cytologic features and loss of heterozygosity of metastatic and/or recurrent neoplasms and primary neoplasms 显示文摘 | Filie AC Chiesa A Bryant BR | 1999 | Cancer1999，87，： | 1 |
| 11 | A Simple Retrieval Method for Land Surface Temperature and Fraction of Water Surface Determination from Satellite Microwave Brightness Temperatures in Sub-arctic Areas显示文摘 | Fily M Royer A Goita K | 2004 | Remote Sensing of Environment2004，85，： | 1 |
| 12 | High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B - cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology 显示文摘 | Hegde U Filie A Little RF | 2005 | Blood2005，105，2： | 1 |
| 13 | Controversial issues in kyphoplasty and vertebroplasty in osteoporotic vertebral fractures 显示文摘 | Papanastassiou ID Filis A Gerochristou MA | 2014 | Biomed Res Int2014，20，93： | 1 |
| 14 | Allergic reactions during allergy skin testing with food allergens显示文摘 | Pitsios C Dimitriou A Kontou - Fili K | 2009 | Eur Ann Allergy Clin lmmunol2009，41，4： | 1 |
| 15 | Genetic diversity among Candida albicans isolates associated with vertical transmission in preterm triplets 显示文摘 | Hoarau G Bougnoux ME Fily A Francois N Loridant S Jawhara S d'Enfert C Poulain D Sendid B | 2014 | Mycopathologia2014，178，34： | 1 |
| 16 | Proteomic evaluation of archival FNA patient sample of papillary of thyroid carcinoma and follicular variant of papillary thyroid carcinoma yields distinct protein fingerprints with potential diagnostic applications 显示文摘 | Filie A Simane N Simone C | 2001 | Mod Pathol2001，14，： | 1 |
| 17 | Combined breast ductal lav-age and ductal endoscopy for the evaluation of the high-riskbreast: a feasibility study显示文摘 | Danforth D N Abati A Filie A | 2006 | J Surg Oncol2006，94，7： | 1 |
| 18 | A Simple Retrieval Method for Land Surface Temperature and Fraction of Water Surface De termination from Satellite Microwave Brightness Tempera- tures in Sub-arctic Areas 显示文摘 | Fily M Royer A Gol K | 2003 | Remote Sensing of Environment2003，85，3： | 1 |
| 19 | Ischemic tolerance in stroke treatment显示文摘 | Sandu N Cornelius J Filis A | | Expert Rev Cardiovasc Ther0，7，10： | 1 |
| 20 | High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement:the role of flow cytometry versus cytology显示文摘 | Hegde U Filie A Little RF | | 0，，02： | 1 |
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