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| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | Diabetes mellitus increases the prevalence of anemia in patients with chronic kidney disease:A nested case-control study显示文摘AIM: To compare anemia prevalence between matched chronic kidney disease(CKD) patients with and without diabetes mellitus(DM) and to assess factors associated with anemia development.METHODS: This is a nested case-control study of 184 type-2 diabetic and 184 non-diabetic CKD patients from a prospectively assembled database of a Nephrology outpatient clinic, matched for gender, age and estimated glomerular filtration rate(eG FR). Prevalence of anemia(hemoglobin: Men: < 13 g/dL, women: < 12 g/dL and/or use of recombinant erythropoietin) was examined in comparison, in the total population and by CKD Stage. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with anemia.RESULTS: The total prevalence of anemia was higher in diabetics(47.8% vs 33.2%, P = 0.004). Accordingly, prevalence was higher in diabetics in CKD Stage 3(53.5% vs 33.1%, P < 0.001) and particularly in Stage 3a(60.4% vs 26.4%, P < 0.001), whereas it was nonsignificantly higher in Stage 4(61.3% vs 48.4%; P = 0.307). Serum ferritin was higher in diabetics in total and in CKD stages, while serum iron was similar between groups. In multivariate analyses, DM(OR = 2.206, 95%CI: 1.196-4.069), CKD Stages 3a, 3b, 4(Stage 4: OR = 12.169, 95%CI: 3.783-39.147) and serum iron(OR = 0.976, 95%CI: 0.968-0.985 per mg/d L increase) were independently associated with anemia.CONCLUSION: Prevalence of anemia progressively increases with advancing stages of CKD and is higher in diabetic than matched non-diabetic CKD patients and diabetes is independently associated with anemia occurrence. Detection and treatment of anemia in diabetic CKD patients should be performed earlier than non-diabetic counterparts. | Charalampos Loutradis Alexandra Skodra Panagiotis Georgianos Panagiota Tolika Dimitris Alexandrou Afroditi Avdelidou Pantelis A Sarafdis | 2016 | World Journal of Nephrology2016，5，4： | 9 |
| 3 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 4 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 5 | The copigmentation effect of sinapie acid on malvin : a spectroscopic in- vestigation on colour enhancement 显示文摘 | DIMITRI M J M PETRANOVI N A BARANAC J M | 2005 | J Photoehem and Photobi- ology2005，78，： | 1 |
| 6 | Tibial plateau fractures : functional outcome and incidence of osteoarthritis in 125 cases显示文摘 | Manidakis N Dosani A Dimitriou R | 2010 | Int Orthop2010，34，4： | 1 |
| 7 | Sensitivity analysis of a star optical network based on mutually coupled semiconductor lasers显示文摘 | Michail B Apostolos A Dimitris S | 2012 | Journal of Lightwave Technology2012，30，16： | 1 |
| 8 | Optimized combined harmonic filtering system显示文摘 | Dimitrie Alexa Sirbu A | 2001 | IEEE Transactions on Industrial Electronics2001，48，6： | 1 |
| 9 | SPICE model and parameters for fully-depleted SO1 MOSFETS Including self-heating显示文摘 | Dimitri A Antoniadis Narain D Arora | 1994 | IEEE Electron Device Letters1994，15，10： | 1 |
| 10 | Nonlinear coupled mechanics and initial bucking of comosite plates with piezoelectric actuators and sensors显示文摘 | Dimitris Varelis Dimitris A S | 2002 | Smart Material and Structure (S0964-1726)2002，11，3： | 1 |
| 11 | The patho physiologic roles of interleukin-6 in human disease 显示文摘 | Dimitris A Papanicolaou MD Ronald L | 1998 | Ann Intern Med1998，128，： | 1 |
| 12 | Acquisitions,overconfident managers and self-attribution bias显示文摘 | Doukas J A Dimitris Petmezas | | 0，，03： | 1 |
| 13 | Single-anten- na coherent detection of collided FM0 RFID signals 显示文摘 | BLETSAS A KIMIONIS J DIMITRIOU A G | 2012 | IEEE Transactions on Communications2012，60，3： | 1 |
| 14 | Tibial plateau frac- tures: functional outcome and incidence of osteoarthritis in 125 cases显示文摘 | Manidakis N Dosani A Dimitriou R | 2010 | Int Orthop2010，34，4： | 1 |
| 15 | Investigation of the Molecular Weight Increase of Commercial Lignosulfonates by Laccase Catalysis显示文摘 | Dimitri A Jiebing Li Goran G | 2010 | Biomacromolecules2010，11，： | 1 |
| 16 | Transcon- junctival orbital decompression in Graves' ophthalmopathy :lateral wall approach ab interno显示文摘 | Dion A Paridaens Karin Verlmeff Dimitri Bouwens | 2000 | Br J Ophthahnol2000，84，7： | 1 |
| 17 | On overfitting,generalization,and randomly expanded training sets显示文摘 | George N Dimitris A | | 0，，05： | 1 |
| 18 | Analysis of the bubbling effect in synchronized networks with semiconductor laser显示文摘 | Michail B Apostolos A Dimitris S | 2013 | IEEE Photonics Technology Letters2013，25，9： | 1 |
| 19 | Antioxidative capabilities of some organic acids and their co-pigments with malvin: part Ⅰ显示文摘 | Jasmina M Dimitri Markovi Ljubia M Ignjatovi Dragan A Markovi | 2003 | J Electroanalytieal Chemistry2003，553，30： | 1 |
| 20 | Theoretical prediction of single-site surface protonation equilibrium constants for oxides and silicates in water显示文摘 | Dimitri A Sverjensky Nita Sahai | 1996 | Geochimiea et Cosmochimica Acta1996，60，20： | 1 |
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