|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 2 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 3 | Laparoscopic fenestration of multiple giant biliary mucinous cystadenomas of the liver显示文摘Biliary cystadenomas of the liver are rare, cystic neoplasms of the biliary ductal system usually occur in middle aged women. We report a case of synchronous multiple huge biliary mucinous cystadenomas with unique features. This is, according to our knowledge, the first report in the literature about three synchronously occurring hepatobiliary cystadenomas. Cystadenomas have a strong tendency to recur, particularly following incomplete excision, and a potential of malignant transformation. A therapeutic re-evaluation may be necessary when the diagnosis of hepatobiliary cystadenoma is made after the operation and an open liver resection should be considered. | A Manours E Lagoudianakis L Alevizos H Markogiannakis G Kafiri C Bramis K Filis K Toutouzas | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
| 4 | Malignant gastrointestinal melanomas of unknown origin: Should it be considered primary?显示文摘TO THE EDITOR We read with interest the article entitled: ‘Jejuno-jejunal invagination due to intestinal melanoma’ by Resta G, et al[1]. They reported a rare clinical case of a young woman with a bleeding jejunal melanoma, whose early | A Manouras M Genetzakis E Lagoudianakis H Markogiannakis A Papadima G Kafiri K Filis PB Kekis V Katergiannakis | 2007 | World Journal of Gastroenterology2007，13，29： | 2 |
| 5 | 14xy InGaAsP/InP ridge waveguide pump laser diodes with low vertical farfield and high efficiency显示文摘 | LICHTENSTEIN N FILY A HERMENS C | 2003 | OFC2003，1，： | 1 |
| 6 | Differential expansion of the N-formyl peptide receptor gene cluser in human and mouse显示文摘 | Gao JL Chen H Filie JD | 1998 | Genomics1998，51，： | 1 |
| 7 | Controversial issues in kyphoplasty and vertebroplasty in osteoporotic vertebral fractures 显示文摘 | Papanastassiou I D Filis A Gerochfistou M A | 2014 | Biomed Res Int2014，2014，93： | 1 |
| 8 | Production of low-fat frankfurters with vegetable oils following the dietary guidelines for fatty acids显示文摘 | Paneras E D Bloukas J G Filis D G | 1998 | Muscle Food1998，，9： | 1 |
| 9 | Dynamic correlation between stock market and oil prices: The case of oil-importing and oil-exporting countries显示文摘 | George Filis Stavros Degiannakis Christos Floros | 2011 | International Review of Financial Analysis2011，，3： | 1 |
| 10 | The Reflectance of Rough Snow in Antarctica from POLDER/ADEOS Remote Sensing Data显示文摘 | Mondet J Fily M | 1999 | Geophys Res Lett1999，26，23： | 1 |
| 11 | Redirection of allergen- specific TH2 responses by a modified adenine through Toll- like receptor 7 interaction and IL-12/IFN release 显示文摘 | Fili L Ferri S Guama F | 2006 | J Al- lergy Clin Immunol2006，118，2： | 1 |
| 12 | Intrasac flow velocities predict sealing of type II endoleaks after endovascular abdominal aortic aneurysm repair 显示文摘 | Arko FR Filis KA Siedel SA | 2003 | J Vasc Surg2003，37，1： | 1 |
| 13 | First Aerosol Optical Thickness Measurements at Dome C (East Antarctica),Summer Season 2003-2004 显示文摘 | Delphine Six Michel Fily Luc Blarel | 2005 | Atmospheric Environment2005，39，： | 1 |
| 14 | Increased vein wall apoptosis in varicose vein disease is related to venous hypertension显示文摘 | Filis K Kavantzas N Isopoulos T | | 0，，4： | 1 |
| 15 | Liver pa- thology and cell proliferation after oetreotide administra- tion following partial hepatectomy in rats:an experimen- tal study显示文摘 | Papalampros E Felekouras ES Filis K | 2002 | Dig Dis Sci2002，47，9： | 1 |
| 16 | The prevalence of trig gets in paediatric migraine: a questionnaire study in 102 children and adolescents显示文摘 | Neut D Fily A Cuvellier JC | 2012 | Headache Pain2012，13，1： | 1 |
| 17 | Increased vein wall apoptosis in varicose vein disease is related to venous hypertension显示文摘 | Filis K Kavantzas N Isopoulos T | 2011 | Eur J Vasc Endovasc Surg2011，41，4： | 1 |
| 18 | Therapeutic implications of osteoprotegerin显示文摘 | Fili S Karalaki M Schaller B | 2009 | Cancer Cell Int2009，9，： | 1 |
| 19 | Trigem-ino-cardiac reflex during transsphenoidal surgery forpituitary adenomas:methodological description of aprospective skull base study protocol显示文摘 | SCHALLER B J WEIGEL D FILIS A | 2007 | Brain Res2007，1149，： | 1 |
| 20 | Expression of CD44 adhesion molecule in colon carcinomas and metastases 显示文摘 | Filis LM Saya H | 1993 | Lancet1993，341，8847： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员