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| 1 | Renin-angiotensin system in the pathogenesis of liver fibrosis显示文摘Hepatic fibrosis is considered a common response to many chronic hepatic injuries.It is a multifunctional process that involves several cell types,cytokines,chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem.In spite of many studies regarding the development of fibrosis,the understanding of the pathogenesis remains obscure.The hepatic tissue remodeling process is highly complex,resulting from the balance between collagen degradation and synthesis.Among the many mediators that take part in this process,the components of the Renin angiotensin system(RAS) have progressively assumed an important role.Angiotensin(Ang)□acts as a profibrotic mediator and Ang-(1-7),the newly recognized RAS component,appears to exert a counter-regulatory role in liver tissue.We briefly review the liver fibrosis process and current aspects of the RAS.This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis,focusing on the putative role of the ACE2-Ang-(1-7)-Mas receptor axis. | Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro Martins Teixeira Ana Cristina Simoes e Silva | 2009 | World Journal of Gastroenterology2009，15，21： | 37 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | Protective effect of linalool, myrcene and eucalyptol against t -butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells显示文摘 | D. Miti?-?ulafi? B. ?egura B. Nikoli? B. Vukovi?-Ga?i? J. Kne?evi?-Vuk?evi? M. Filipi? | 2008 | Food and Chemical Toxicology2008，，1： | 1 |
| 4 | Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert- butyl hydroperoxide ( t -BOOH) in HepG2 human hepatoma cells显示文摘 | Janja Plazar Bojana ?egura Tamara T. Lah Metka Filipi? | 2007 | MutRes-Genetic Toxicology and Environmental Mutagenesis2007，，1： | 1 |
| 5 | Integrated,feed-forward hybrid electric vehicle simulation in Simulink and its use for power management studies显示文摘 | Lin Chanchiao Filipi Z Wang Yongsheng | 2001 | SAE Paper2001，，1： | 1 |
| 6 | Identification and quantification of volatile organic compounds from a dairy 显示文摘 | Filipy J Rumburg B Mount G | 2006 | Atmospheric Environment2006，40，8： | 1 |
| 7 | Evaluation of supplemental cautery during endoluminal gastroplication for the treatment of gastroesophageal reflux disease显示文摘 | Patrick Mosler Ayman M. Abdel Aziz Karen Hieston Charles Filipi Glen Lehman | 2008 | Surgical Endoscopy2008，，10： | 1 |
| 8 | Mechanisms of hernia recurrence after preperitoneal mesh repair显示文摘 | Lawham As Filipi CJ Fitzgibbons RJ | 1997 | Ann Surg1997，225，： | 1 |
| 9 | A laparoscopic intraperitoneal onlay mesh technique for the repair of indirect,inguinal hernia显示文摘 | Salerno GM Filipi CJ | 1994 | Ann Surg1994，219，2： | 1 |
| 10 | Series Hydraulic Hybrid Propulsion for a Light Truck显示文摘 | Y J Kim Z Filipi | 2007 | SAE2007，，： | 1 |
| 11 | Laparoscopic herniorrhaphy显示文摘 | Fitzgibbons RJ Salerno GM | 1992 | Surg Clin North Am1992，72，5： | 1 |
| 12 | Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2 显示文摘 | Zegura B Sedmak B Filipiǒ M | 2003 | Toxicon2003，41，1： | 1 |
| 13 | Comparison of Supervisory Control Strategies for Series Plug-in Hybrid Electric Vehicle Powertrains Through Dynamic Programming 显示文摘 | Patil R M Filipi Z Fathy H K | 2014 | IEEE Transactions on Control Systems Technology2014，22，2： | 1 |
| 14 | Correlations between esophageal diseases and manometric length: A study of 617 patients 显示文摘 | Awad ZT Watson P Filipi CJ | 1999 | J Gastrointest Surg1999，3，5： | 1 |
| 15 | Surgery for achalasia:1998 显示文摘 | Shiino Y Filipi CJ Award ZT | 1999 | J Gastrointes Surg1999，3，5： | 1 |
| 16 | Indications for endo-organ gastric excision 显示文摘 | Mittal SK Filipi CJ | 2000 | Surg Endosc2000，14，4： | 1 |
| 17 | A brain NRI study of dif ferent types of chronic progressive multiple sclerosis 显示文摘 | Filipi M Campi A Martinelli V | 1995 | Acta Neurol Scand1995，91，： | 1 |
| 18 | Preactivated Iota-carrageenan and its Rheological Effects in Composite Surimi Gel显示文摘 | Filipi I Lee CM | 1998 | Journal of Agricultural and Food Chemistry1998，31，2： | 1 |
| 19 | Laparoscopic paraesophageal hernia repair 显示文摘 | Perdikis G Hinder RA Filipi C J | 1997 | Arch Surg1997，132，6： | 1 |
| 20 | Transoral, flexible endoscopic sutering for treatment of GERD:a muhicenter trial显示文摘 | Filipi CJ Glen AL Richard IR | 2001 | Gastrointestinal Endoscopy2001，53，2： | 1 |
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