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| 1 | 成人、儿童及孕妇特发性血小板减少性紫癜诊治指南显示文摘特发性血小板减少性紫癜(ITP)是一种自体免疫性疾病,以持续性血小板减少为特征(血小板<150×109/L).其发病机理是自身抗体与血小板抗原结合导致它们在未成熟时即被网状内皮系统,特别是在脾脏中被破坏引起血小板减少. | Provan D Newland A Norfolk D Bolton-Maggs P Lilleyman J Greer I May A Murphy M Ouwehand W Watson S 李振宇 徐开林 | 2004 | 国外医学(输血及血液学分册)2004，27，4： | 25 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | 麻风无痛性神经炎——康复试点报告显示文摘对八个康复试点的3571例病人定期进行神经功能检查,发现无痛性神经炎151例(4.2%),共累及330条神经,包括面神经15条,尺神经98条,正中神经36条,胫后神经148条及腓总神经33条。经强的松标准方案治疗,神经功能好转235条(71.2%),其中恢复优、良者196条(59.4%),表明强的松治疗麻风无痛性神经炎既简单又行之有效,可作为常规,以减少神经不可逆性损害。讨论了无痛性神经炎与MDT的关系及其感觉与运动功能的恢复。 | 蒋娟 张国成 韦晓宇 严良斌 李文忠 郑逖生 Jakeman P Watson J Smith C Goh Siam Kiang | 1996 | 中国麻风杂志1996，12，3： | 5 |
| 4 | The inefficiency of least squares显示文摘 | BLOOMFIELD P WATSON G S | 1975 | Biometrika1975，62，： | 2 |
| 5 | Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation显示文摘 | GAUVREAU G M WATSON R M O'BYRNE P M | 1999 | Am J Respir Crit Care Med1999，160，2： | 1 |
| 6 | Hereditary breast cancer:pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage显示文摘 | Watson P Page DL | 1996 | Cancer1996，77，4： | 1 |
| 7 | The percutaneous absorption of lead-203 in humans from cosmetic preparations containing lead acetate, as assessed by whole-body counting and other techniques 显示文摘 | Moore M Meredith P Watson W | 1980 | Food and Cosmetics Toxicology1980，18，： | 1 |
| 8 | Peanut hull pel- lets as a single use sorbent for the capture of Cu( Ⅱ )from wastewater 显示文摘 | Johnson P D Watson M A Brown J | 2002 | Waste Management2002，22，5： | 1 |
| 9 | Salmonella pathogenicity island 2 influences both systemic Salmonellosis and Salmonella in duced enteritisincalves显示文摘 | Bispham J Tripathi B N Watson P R | 2001 | Infection and Immunity2001，69，： | 1 |
| 10 | Maturity indices for composted dairy and pig manures显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 11 | Prognostic significance of a novel hypoxia-regulated marker,carbonic anhydrase IX,in invasive breast carcinoma显示文摘 | Chia S K Wykoff C C Watson P H | 2001 | J Clin Oncol2001，19，16： | 1 |
| 12 | A photothrombotic ring model of rat stroke-in-evolution displaying putative penumbral inversion显示文摘 | Wester P Watson BD Prado R | 1995 | Stroke1995，26，3： | 1 |
| 13 | An experimental study with a vortex magnet- ic separation ( VMS ) device 显示文摘 | Li Z N Watson J H P | 1996 | Minerals Engineering1996，9，3： | 1 |
| 14 | Positional vertigo andnystagmus of central origin显示文摘 | Watson P Barber HO Deck J | 1981 | Can J Neurol Sci1981，8，： | 1 |
| 15 | Anatomical para- meters for predicting photosynthetic pathways of grass leaves: the maximum lateral cell count and the maximum cellsdistant count显示文摘 | HATTERSLEY P W WATSON L | 1975 | Phytomorphology1975，25，3： | 1 |
| 16 | Air-sea gas exchange in rough and stormy seas measured by a dual-tracer technique显示文摘 | Watson A J Upstill Goddard C R Liss P S | 1991 | Nature1991，349，14： | 1 |
| 17 | Cooling of spermatozoa and fertilizing capacity 显示文摘 | Watson P F | 1995 | Reprod Domest Anim1995，31，： | 1 |
| 18 | Colon cancer: a civilization disorder显示文摘 | Watson A J Collins P D | 2011 | Dig Dis2011，29，2： | 1 |
| 19 | Angioedema as a hypersensitivity reaction to polyethylene glycol oral electrolyte solution显示文摘 | Assal C Watson P Y | 2006 | Gastrointest Endosc2006，64，2： | 1 |
| 20 | Aeute dopamine/no- radrenaline reuptake inhibition enhanees human exercise perform- anee in warm, but not temperate eanditions显示文摘 | Watson P Hasegawa H Roelands B | 2005 | J Physiol2005，565，3： | 1 |
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