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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2 显示文摘 | Zegura B Sedmak B Filipiǒ M | 2003 | Toxicon2003，41，1： | 1 |
| 3 | Comparison of Supervisory Control Strategies for Series Plug-in Hybrid Electric Vehicle Powertrains Through Dynamic Programming 显示文摘 | Patil R M Filipi Z Fathy H K | 2014 | IEEE Transactions on Control Systems Technology2014，22，2： | 1 |
| 4 | A brain NRI study of dif ferent types of chronic progressive multiple sclerosis 显示文摘 | Filipi M Campi A Martinelli V | 1995 | Acta Neurol Scand1995，91，： | 1 |
| 5 | Climatic and anthropogenic influence on the stable isotope record from bulk carbonates and ostracodes in Lake Neuchatel,Switzerland,during the last two millennia显示文摘 | Lambert P Hunziker J Kübler B Bernasconi S | 1999 | J Paleolimnol1999，21，： | 1 |
| 6 | Comparison of supervisory control strategies for series plug-in hybrid electric vehicle powertrains through dynamic programming显示文摘 | Patil R M Filipi Z Fathy H K | 2014 | IEEE Transactions on Control Systems Technology2014，22，2： | 1 |
| 7 | Mechanisms of cadmium induced genomic instability显示文摘 | Filipi觬M | 2012 | Mutation Research2012，733，12： | 1 |
| 8 | Comparison of supervisory control strategies for series plug-in hybrid electric vehicle powertrains through dynamic programming显示文摘 | Patil R M Filipi Z Fathy H K | 2013 | IEEE Transactions on Control System Technology2013，22，2： | 1 |
| 9 | The influence of cylindrospermopsin on oxidative DNA damage and apoptosis induction in HepG2 cells显示文摘 | Straser A Filipi(c) M Gorenc I Zegura B | | 0，，01： | 1 |
| 10 | The role of reactive oxygen species in microcystin-LR-induced DNA damage 显示文摘 | Zegura B Tamara T L and Filipie M | 2004 | Toxicology2004，200，1： | 1 |
| 11 | Comparison of supervisorycontrol strategies for series plug-in hybrid electric vehiclepowertrains through dynamic programming显示文摘 | Patil R M Filipi Z Fathy H K | 2014 | IEEE Trans-actions on Control Systems Technology2014，22，2： | 1 |
| 12 | Preactivated Iota-carrageenan and its Rheological Effects in Composite Surimi Gel显示文摘 | Filipi I Lee C M | 1998 | Lebensm-Wiss u- Teehnol1998，31，： | 1 |
| 13 | Comparison of supervisory control strategies for series plug-in hybrid electric vehicle powertrains through dynamic programming显示文摘 | PATIL R M FILIPI Z | 2014 | IEEE Transactions on Control Systems Technology2014，22，2： | 1 |
| 14 | Mechanisms of cadmium induced genomic instability显示文摘 | Filipi(c) M | 2012 | Mutat Res2012，733，12： | 1 |
| 15 | Infrared Light Management in High-efficiency Silicon Heterojunction and Rear-passivated Solar Cells显示文摘 | Holman Z C Filipi M Descoeudres A | 2013 | Journal of applied Physics2013，113，1： | 1 |
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