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| 1 | Infectious burden and atherosclerosis: A clinical issue显示文摘Atherosclerotic cardiovascular diseases, chronic inflam-matory diseases of multifactorial etiology, are the lead-ing cause of death worldwide. In the last decade, more infectious agents, labeled as 'infectious burden', rather than any single pathogen, have been showed to con-tribute to the development of atherosclerosis through different mechanisms. Some microorganisms, such as Chlamydia pneumoniae(C. pneumoniae), human cytomegalovirus, etc. may act directly on the arterial wall contributing to endothelial dysfunction, foam cell formation, smooth muscle cell proliferation, platelet ag-gregation as well as cytokine, reactive oxygen specie, growth factor, and cellular adhesion molecule produc-tion. Others, such as Helicobacter pylori(H. pylori), in-fluenza virus, etc. may induce a systemic inflammation which in turn may damage the vascular wall(e.g., by cytokines and proteases). Moreover, another indirect mechanism by which some infectious agents(such as H. pylori, C. pneumoniae, periodontal pathogens, etc.) may play a role in the pathogenesis of atherosclero-sis is molecular mimicry. Given the complexity of the mechanisms by which each microorganism may con-tribute to atherosclerosis, defining the interplay of moreinfectious agents is far more difficult because the pro-atherogenic effect of each pathogen might be ampli-fied. Clearly, continued research and a greater aware-ness will be helpful to improve our knowledge on the complex interaction between the infectious burden and atherosclerosis. | Rosa Sessa Marisa Di Pietro Simone Filardo Ombretta Turriziani | 2014 | World Journal of Clinical Cases2014，2，7： | 17 |
| 2 | Biologic agents for anterior cruciate ligament healing: a systematic review显示文摘AIM To systematically review the currently available literature concerning the application of biologic agents such as platelet-rich plasma(PRP) and stem cells to promote anterior cruciate ligament(ACL) healing.METHODS A systematic review of the literature was performed on the use of biologic agents(i.e., PRP or stem cells) to favor ACL healing during reconstruction or repair. The following inclusion criteria for relevant articles were used: Clinical reports of any level of evidence, written in English language, on the use of PRP or stem cells during ACL reconstruction/repair. Exclusion criteria were articles written in other languages, reviews, or studies analyzing other applications of PRP/stem cells in knee surgery not related to promoting ACL healing.RESULTS The database search identified 394 records that were screened. A total of 23 studies were included in the final analysis: In one paper stem cells were applied for ACL healing, in one paper there was a concomitant application of PRP and stem cells, whereas in the remaining21 papers PRP was used. Based on the ACL injury pattern, two papers investigated biologic agents in ACL partial tears whereas 21 papers in ACL reconstruction.Looking at the quality of the available literature, 17 out of 21 studies dealing with ACL reconstruction were randomized controlled trials. Both studies on ACL repair were case series.CONCLUSION There is a paucity of clinical trials investigating the role of stem cells in promoting ACL healing both in case of partial and complete tears. The role of PRP is still controversial and the only advantage emerging from the literature is related to a better graft maturation over time, without documenting beneficial effects in terms of clinical outcome, bone-graft integration and prevention of bony tunnel enlargement. | Berardo Di Matteo Markus Loibl Luca Andriolo Giuseppe Filardo Johannes Zellner Matthias Koch Peter Angele | 2016 | World Journal of Orthopedics2016，7，9： | 3 |
| 3 | Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor显示文摘 | Edward J. Filardo Jeffrey A. Quinn Edmond Sabo | 2008 | Steroids2008，，9： | 2 |
| 4 | 基质辅助自体软骨细胞移植治疗髌股关节软骨损伤——髌骨与滑车损伤修复疗效对比显示文摘由于自身愈合能力有限,软骨损伤修复一直以来都具有临床挑战性。膝关节软骨损伤患病率高,尤以髌股关节软骨损伤最为多见。基质辅助自体软骨细胞移植(matrix-assisted autologous chondrocyte transplantation,MACT)中期随访显示出良好疗效,但对于不同患者及不同损伤类型,治疗结果各异。本研究的目的在于对同一手术团队采取同一术式治疗的髌股关节软骨缺损的中期疗效进行前瞻性队列研究,明确髌骨和滑车软骨缺损治疗后是否存在临床愈合结果的差异。 | Filardo G Kon E Andriolo L 沈洪园 章莹 | 2015 | 中国骨科临床与基础研究杂志2015，7，1： | 2 |
| 5 | Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells 显示文摘 | Thomas P Pang Y Filardo E J | 2005 | Endocrinology2005，146，2： | 1 |
| 6 | Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog,GPR30,and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF显示文摘 | Filardo EJ Quinn JA Bland KI | | 0，，： | 1 |
| 7 | Monetary Policy and Asset Prices显示文摘 | Filardo A.J | | 0，，03： | 1 |
| 8 | Platelet-rich plasma intraarticular injections for cartilage degeneration and osteoarthritis : single- versus double-spinning approach 显示文摘 | Filardo G Kon E Pereira Ruiz MT | 2012 | Knee Surg Sports Traumatol Arthrosc2012，20，： | 1 |
| 9 | Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis显示文摘 | FILARDO G KON E BUDA R | 2011 | Knee Surgery Sports Traumatology Arthroscopy2011，19，4： | 1 |
| 10 | Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog,GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF显示文摘 | Filardo EJ Quinn JA Bland KI | 2000 | Mol Endocrinol2000，10，： | 1 |
| 11 | Estrogen-induced activa- tion of Erk-1 and Erk-2 requires the G protein-coupled receptor homo- log, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF 显示文摘 | Filardo E J Quinn J A Bland K l | 2000 | Mol Endocrinol2000，14，10： | 1 |
| 12 | Estrogen action via the G protein-coupled receptor,GPR30:stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis显示文摘 | Filardo EJ Quinn JA Frackelton AR Jr | | 0，，： | 1 |
| 13 | A hospital randomized controlled trial of an educational quality improvement intervention in rural and small community hospitals in Texas following implementation of information technology显示文摘 | Filardo G Nicewander D Hamilton C | | 0，，6： | 1 |
| 14 | Activation of the novel estrogen receptor G protein-coupled receptor 30(GPR30)at the plasma membrane显示文摘 | FILARDO E QUINN J PANG Y | 2007 | Endocrinology2007，148，7： | 1 |
| 15 | Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane 显示文摘 | Filardo E Quinn J Pang Y | 2007 | Endocrinology2007，148，： | 1 |
| 16 | Platelet-rich plasma vs hyaluronic add totreat knee degenerative pathology: study design and preliminary results of arandomized controlled trial显示文摘 | Filardo G* Kon E di iVfertino A | 2012 | BMC Masculoskelet Disord2012，13，： | 1 |
| 17 | Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells显示文摘 | Thomas P Pang Y Filardo EJ | | 0，，： | 1 |
| 18 | Second - generation arthro- scopie autologous chondrocyte implantation for the treatment of de- generative cartilage lesions显示文摘 | Filardo G Kon E Di Martino A | 2012 | Knee Surg Sports TraumatM Arthro- sc2012，20，9： | 1 |
| 19 | Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells 显示文摘 | Thomas P Pang Y Filardo E J | 2005 | Endocrinology2005，146，2： | 1 |
| 20 | GPR30:a seven-transmembrane-spanning estrogen receptor that triggers EGF release显示文摘 | Filardo FJ Thomas P | 2005 | Trends Endocrinol Metab2005，16，8： | 1 |
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