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| 1 | Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia显示文摘AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy controls.METHODS Forty stable schizophrenia outpatients(20 Insight-and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging(MRI).Insight in all patients was assessed using the Birchwood Insight Scale(BIS;a self-report measure).The two patient groups were preselected to match on most clinical and demographic parameters but,by design,they had markedly distinct BIS scores.Voxel-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole brain.RESULTS The three participant groups were comparable in age [F(2,57) = 0.34,P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87,P = 0.39].Insight-and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale(PANSS):Positive symptoms [t(38) = 0.58,P = 0.57],negative symptoms [t(38) = 0.61,P = 0.55],general psychopathology [t(38) = 1.30,P = 0.20] and total PANSS scores [t(38) = 0.21,P = 0.84].The two patient groups,as expected,varied significantly in the level of BIS-assessed insight [t(38) = 12.11,P < 0.001].MRI results revealed lower fronto-temporal,parahippocampal,occipital and cerebellar grey matter volumes in Insightpatients,relative to Insight+ patients and healthy controls(for all clusters,family-wise error corrected P < 0.05).Insight+ patient and healthy controls did not differ significantly(P > 0.20) from each other.CONCLUSION Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal,occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients. | Adegboyega Sapara Dominic H Ffytche Michael A Cooke Steven CR Williams Veena Kumari | 2016 | World Journal of Psychiatry2016，6，3： | 3 |
| 2 | Perisylvian language networks of the human brain显示文摘 | Catani M Jones D K Ffytche D H | 2005 | Ann Neurol2005，57，1： | 1 |
| 3 | The rises and falls of disconnection syn- dromes显示文摘 | Catani M Ffytche DH | 2005 | Brain2005，128，10： | 1 |
| 4 | Self-responsibility and the self-serving bias:an fMRI investigation of causal attributions显示文摘 | Blackwood NJ Bentall RP ffytche DH | 2003 | Neuroimage2003，20，2： | 1 |
| 5 | Long-term follow-up of diode laser trabeculoplasty for primary open-angle glaucoma and ocular hypertension显示文摘 | Moriarty AP McHugh JD Ffytche TJ | 1993 | Ophthalmology1993，100，11： | 1 |
| 6 | Vision 2020: the right to sight: a global initiative to eliminate avoidable blindness显示文摘 | Pizzarello L Abiose A Ffytche T | 2004 | Arch Ophthalmol2004，122，4： | 1 |
| 7 | The MacDQoL Individualized Measure of the Impact of Macular Degeneration on Quality of Life: Reliability and Responsiveness显示文摘 | Jan Mitchell James Wolffsohn Alison Woodcock Stephen J. Anderson Timothy Ffytche Martin Rubinstein Winfried Amoaku Clare Bradley | 2008 | American Journal of Ophthalmology2008，，3： | 1 |
| 8 | Intravitreal trimicinolone for uveitic cystoid macular edema: an optical coherence tomography study显示文摘 | Antcliff RJ Spalton DJ Stanford MR Graham EM Ffytch TJ Marshall J | 2001 | Ophthalmology2001，108，： | 1 |
| 9 | Cognitive effects of nicotine in humans : an fMRI study 显示文摘 | Kumari V Gray JA Ffytche DH | 2003 | Neuroimage2003，19，： | 1 |
| 10 | A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics显示文摘 | Kumari V Antonova E Geyer MA Ffytche D Williams SC Sharma T | | 0，，： | 1 |
| 11 | Perisylvian language networks of the human brain显示文摘 | Catani M Jones DK ffytche DH | 2005 | Ann Neurology2005，57，： | 1 |
| 12 | Cognitive effects of nicotine in humans: an fMRI study显示文摘 | Kumari V Gray JA Ffytche DH | 2003 | Neuroimage2003，19，3： | 1 |
| 13 | Cognitiv e effects of nicotine in humans: An fMRI study显示文摘 | Kumari V Gray J A Ffytche D H | 2003 | Neuroimage2003，19，： | 1 |
| 14 | The rises and falls of disconnection syndromes显示文摘 | Catani M Ffytche D H | 2005 | Brain2005，128，10： | 1 |
| 15 | Cognitive effects of nicotine in humans:An fMRI study显示文摘 | Kumari V Gray JA ffytche DH | 2003 | Neuroimage2003，19，： | 1 |
| 16 | Optical coherence tomography of melanocytoma显示文摘 | Antcliff R J Ffytche T J Shilling J S | 2000 | Am J Ophthalmol2000，130，： | 1 |
| 17 | Perisylvian language networks of the human brain 显示文摘 | Catani M Jones DK Ffytche DH | 2005 | Ann Neurology2005，57，1： | 1 |
| 18 | Intravitreal triamcinolone for uveitic cystoid macular edema:an optical coherence tomography study显示文摘 | Antcliff R J Spalton DJ Stanford MR Graham EM Ffytche TJ Marshall J | | 0，，04： | 1 |
| 19 | Intravitreal triamcinolone for uveitic cystoid macular edema:an optical coherence tomography显示文摘 | Antcliff RJ Spalton DJ Stanford MR Graham EM Ffytche TJ Marshall J | 2001 | Ophthalmology2001，108，4： | 1 |
| 20 | The functional significa nce of perinatal corpus callosum damage:an MRI study in young adults显示文摘 | Santhouse AM Ffytche DH Howard RJ | 2002 | Brain2002，125，8： | 1 |
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