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1A living foundry for Synthetic Biological Materials:A synthetic biology roadmap to new advanced materials显示文摘Society is on the cusp of harnessing recent advances in synthetic biology to discover new bio-based products and routes to their affordable and sustainable manufacture.This is no more evident than in the discovery and manufacture of Synthetic Biological Materials,where synthetic biology has the capacity to usher in a new Materials from Biology era that will revolutionise the discovery and manufacture of innovative synthetic biological materials.These will encompass novel,smart,functionalised and hybrid materials for diverse applications whose discovery and routes to bio-production will be stimulated by the fusion of new technologies positioned across physical,digital and biological spheres.This article,which developed from an international workshop held in Manchester,United Kingdom,in 2017[1],sets out to identify opportunities in the new materials from biology era.It considers requirements,early understanding and foresight of the challenges faced in delivering a Discovery to Manufacturing Pipeline for synthetic biological materials using synthetic biology approaches.This challenge spans the complete production cycle from intelligent and predictive design,fabrication,evaluation and production of synthetic biological materials to new ways of bringing these products to market.Pathway opportunities are identified that will help foster expertise sharing and infrastructure development to accelerate the delivery of a new generation of synthetic biological materials and the leveraging of existing investments in synthetic biology and advanced materials research to achieve this goal.Rosalind A.Le Feuvre Nigel S.Scrutton 2018Synthetic and Systems Biotechnology2018,3,2:6
2Interleukin-18 induces expession and release of cytokines from murine glial cells: interactions with interleukin-10显示文摘Wheeler R D Brough D Le Feuvre R A 2003Journal of Neurochemistry2003,85,6:1
3Silent myocardial ischemia screening in patients with diabetes mellitus 显示文摘Barthelemy O Le Feuvre C Timsit J 2007Arq Bras Endocrinol Metabol2007,51,2:1
4Comparison of short and long-term outcomes of coronary angioplasty in patients with and without diabetes mellitus and with and without hemodialysis显示文摘Le Feuvre CL Borentain M Beygui F 2003Am J Cardiol2003,92,6:1
5Comparison of short-term and long-term outcomes of coronary angioplasty in patients with and without diabetes mellitus and with and without hemodialysis 显示文摘LE FEUVRE C BORENTAIN M BEYGUI F 2003Am J Cardiol2003,92,6:1
6CNS injury:the role of the cytokine IL-1显示文摘Gibson RM Rothwell NJ Le Feuvre RA 0,,03:1
7Comparison of short-term and long-term outcomes of coronary angiop lasty in patients with and without diabetesmellitus and with and without hemodialysis显示文摘Le Feuvre C Borentain M Beygui F 2003J Am Coll Cardiol2003,92,6:1
8Cardiac events after low osmolar ionic or isosmolar nonionic contrast media utilization in the current era of coronary angioplasty显示文摘Le Feuvre C Batisse A Collet JP 2006Catheter Cardiovasc In- terv2006,67,6:1
9Accuracy of multislice computed tomography in the preoperative assessment of coronary disease in patients scheduled for heart valve surgery显示文摘Réda Jakamy Olivier Barthélémy Claude Le Feuvre Emmanuel Berman Rhéda Boutekadjirt Philippe Cluzel Jean-Philippe Metzger Gérard Helft 20122012 (8-9)2012,,8:1
10Telomere shortening associated with chromosome instablity is arrested in immortal cells which express telomerase activity 显示文摘Counter CM Avilion AA Le Feuvre CE 1992EMBO J1992,11,5:1
11Purinergic (P2X7) receptor activa- tion of microglia induces cell death via an interleukin-1-independent mechanism 显示文摘Brough D Le Feuvre RA Iwakura Y 2002Mol Cell Neurosci2002,19,2:1
12lnvolvment of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds 显示文摘Le Feuvre RA Aisenthal L Rothwell NJ 1991Brain Res1991,555,2:1
13Comparison of short- term and long - term outcomes of coronary angiop lasty in patients with and without diabetesmellitus and with and without hemodiaiysis 显示文摘Ee Feuvre C Borentain M Beygui F 2003J Am Coil Cardiol2003,92,6:1
14Design of an efficient scalable vector graphics player for constrained devices 显示文摘Concolato C Feuvre J L Moissinac J C 2008IEEE Transactions on Consumer Electronics2008,54,2:1
15Turnover of soil organic matter under pasture as determined by 13 C natural abundance显示文摘Skjemstad J O Le Feuvre R P Prebble R E 1990Australia Journal of Soil Research1990,28,:1
16Allelic variations of the vitamin D receptor ( VDR ) gene are associated with increased risk of coronary artery disease in type 2 diabetics: The DIABHYCAR prospective study显示文摘D.A.F. Ferrarezi N. Bellili-Mu?oz D. Dubois-Laforgue N. Cheurfa A. Lamri A.F. Reis C. Le Feuvre R. Roussel F. Fumeron J. Timsit M. Marre G. Velho 2013Diabetes and Metabolism2013,,3:1
17Turnover of soil organic matter under pasture as determined by ^13C abundance显示文摘Skjemstad J O Le Feuvre R P Prebbie R E 1990Australian Journal of Soil Science1990,28,:1
18Interleukin-18 induces expession and release of cytokines from murine glial cells:interactions with interleukin-1β显示文摘Wheeler R D Brough D Le Feuvre R A 2003Journal of Neurol chemistry2003,85,6:1
19CNS injury: the role of the cytokine IL-1显示文摘Gibson R M Rothwell N J Le Feuvre R A 2004Vet J2004,168,3:1
20Comparison of short-term and long-term outcomes of coronary angiop lasty in patients with and without diabetesmellitus and with and without hemodialysis显示文摘Le Feuvre C Borentain M Beygui F 2003J Am Coll Cardiol2003,92,6:1
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