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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A connection between orthogonal polynomials on the unit circle and matrix orthogonal polynomials on the real line显示文摘 | M J Cantero M P Ferrer L Moral L Velazquez | 2003 | Journal of Computational and Applied Mathematics2003，154，2： | 1 |
| 3 | Natural occurrence of abscisic acid in heather honey and floral nectar显示文摘 | Ferreres F Andrade P Franeisco A | 1996 | J Agric FoodChem1996，44，： | 1 |
| 4 | Structural basis for the modulation of CDK-de- pendent/independent activity of cyclin DI显示文摘 | Ferrer J L Dupuy J Bore1 F Jacquamet L Noel J P Dulic V | 2006 | Cell Cy- cle2006，5，： | 1 |
| 5 | Bi-phasic growth patterns in rice显示文摘 | Sheehy J E Mitchell P L Ferrer A B | 2004 | Annals of Botany2004，94，6： | 1 |
| 6 | Alien predators and amphibian declines:review of two decades of science and the transition to conservation显示文摘 | FERRER R P | 2003 | Diversity and Distributions2003，9，： | 1 |
| 7 | Sequential measurements of procalcitonin levels in diagnosing ventilator-associated pneumonia显示文摘 | Ramirez P Garcia MA Ferrer M | | 0，，02： | 1 |
| 8 | Sequential measurements of procalcitonin levels in diagnosing ventilator-associated pneumonia显示文摘 | Ramirez P Garcia MA Ferrer M | 2008 | Eur Respir J2008，31，13： | 1 |
| 9 | Use of modifiedatmospheres to prolong the postharvest life of Burlat cherries at two differentdegrees of ripeness 显示文摘 | Remon S Ferrer A Marquina P | 2000 | Journal of the science of Food and Agriculture2000，80，： | 1 |
| 10 | Use of modified atmosphere to prolong the postharvest life of Burlat cherries at tow different degrees of ripeness显示文摘 | Remon S Ferrer A Marquina P | 2000 | J Sci Food Agric2000，80，： | 1 |
| 11 | Visual function in pseudophakic eyes with poly (methyl methacrylate),silicone,and acrylic intraocular lens显示文摘 | Kohnen S Ferrer A Brauweiler P | 1996 | J Cataract Refract Surg1996，22，2： | 1 |
| 12 | Analysis of Honey Phenolic Acid by HPLC, Its Application to Honey Botanical Charaterization显示文摘 | Andrade P Ferreres F Amaral M T | 1997 | J Liq Chrom & Rel Technol1997，20，14： | 1 |
| 13 | Sequential measurements of procalcitonin levels in diagnosing ventilator-associated pneumonia显示文摘 | Ramirez P Garcia MA Ferrer M | | 0，，02： | 1 |
| 14 | Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris显示文摘 | Minning S Serrano A Ferrer P Sola C Schmid R.D Valero F | | 0，，： | 1 |
| 15 | Adverse unidentified transfusion reactions in five French regions: analysis, reults, propositions显示文摘 | Aullen J P Delbose A Ferrer Le Coeur F | 2010 | Transfus Clin Biol2010，17，1： | 1 |
| 16 | 显示文摘 | Ferrer P Iglesias J E Castro A | 2004 | Journal of Materials Science2004，39，： | 1 |
| 17 | Alien predators and amphibian declines : review of two decades of science and the transition to conservation 显示文摘 | Kats L B Ferrer R P | 2003 | Diversity and Distribution2003，9，： | 1 |
| 18 | Dissection of malonyl-coenzyme a decarboxylation from polyketide for marion in the reaction mechanism of a plant polyketide synthase显示文摘 | JEZ J M FERRER J L BOWMAN M E DIXON R A NOEL J P | 2000 | Biochemistry2000，39，5： | 1 |
| 19 | Mining genomes and 'metagenomes' for novel catalysts 显示文摘 | Ferrer M Martinez-Abarca F Golyshin P N | 2005 | Curr Opin Biotechnol2005，16，6： | 1 |
| 20 | New phenolic compounds and antioxidant potential of Catharanthus ro- seus显示文摘 | Ferreres F Pereira DM Valentao P Andrade PB Seabra RM Sottomayor M | 2008 | J Agric Food Chem2008，56，21： | 1 |
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