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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Pre-oxidation of an extremely polluted industrial wastewater by the Fenton’s reagent显示文摘 | Nora San Sebastián Mart??nez Josep F??guls Fernández Xavier Font Segura Antoni Sánchez Ferrer | 2003 | Journal of Hazardous Materials2003，，3： | 2 |
| 4 | Benign tumors of the parotid gland 显示文摘 | Pons Rocher F Lopez Molla C Ferrer Ramirez M J | 2004 | An Otorrinolaringol Ibero Am2004，31，5： | 1 |
| 5 | Noninvasive ventilation during persistent weaning failure:a randomized eontrlled trial显示文摘 | Ferrer M Esquinas A Arancibia F | 2003 | Am J Respir Crit Care Meal2003，168，1： | 1 |
| 6 | Increasing biogas production by thermal (70℃) sludge we-treatment prior to thermophilic anaerobic digestion显示文摘 | I Ferrer S Pons℃ F Vázquez | 2008 | Biochemical Engineering2008，42，： | 1 |
| 7 | Lipase catalysed regioselective aeylation of sucrose in two- solvent mixtures 显示文摘 | M Ferrer M A Cruces M Bernabe A Ballesteros F J Plou | 1999 | Biotechnol Bioeng1999，65，： | 1 |
| 8 | Natural occurrence of abscisic acid in heather honey and floral nectar显示文摘 | Ferreres F Andrade P Franeisco A | 1996 | J Agric FoodChem1996，44，： | 1 |
| 9 | Noninvasive ventilation during persistent weaning failure: a randomized controlled trial 显示文摘 | Ferrer M Esqinas A Arancibia F | 2003 | Am J Respir Crit Care Med2003，168，1： | 1 |
| 10 | Noninvasive ventilation during persistent weaning failure:a randomized controlled trial显示文摘 | Ferrer M Esquinas A Arancibia F et aI | 2003 | Am J Respir Crit Care Meal2003，186，1： | 1 |
| 11 | Cephalexin Residue Detection in Milk and Beef by ELISA and Colloidal Gold Based One Step Strip Assay显示文摘 | Chen L B Wang Z F Ferrer M | 2009 | Agric Food Chem2009，，57： | 1 |
| 12 | Noninvasive ventilation during persistent weaning failure : a randomized controlled trial 显示文摘 | Ferrer M Esquinas A Arancibia F | 2003 | Am J Respir Crit Care Med2003，168，1： | 1 |
| 13 | Long term operation of a thermophilic anaerobic reactor: process stability and effi- ciency at decreasing sludge retention time 显示文摘 | Ivet ferrer F vazquez | 2010 | Bioresour Technol2010，101，9： | 1 |
| 14 | The low scrotal approach to the ectopic or ascended testicle:prevalence of a patent processus vaginalis显示文摘 | Parsons JK Ferrer F Docimo SG | | 0，，： | 1 |
| 15 | Primary small cell carcinoma of the esophagus : a review of the literature with emphasis on therapy and prognosis 显示文摘 | CASAS F FERRER F FARRUS B | 1997 | Cancer1997，80，8： | 1 |
| 16 | Proteomic analysis of human vitreous fluid by fluorescence based difference gel electrophoresis (DIGE):a new strategy for identifying potential candidates in the patho- genesis of proliferative diabetic retinopathy 显示文摘 | Garcia-Ramirez M Canals F Hemandez C Colome N Ferrer C Carrasco E | 2007 | Diabetologia2007，50，6： | 1 |
| 17 | Structural basis for the modulation of CDK-de- pendent/independent activity of cyclin DI显示文摘 | Ferrer J L Dupuy J Bore1 F Jacquamet L Noel J P Dulic V | 2006 | Cell Cy- cle2006，5，： | 1 |
| 18 | Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1显示文摘 | FERRER J L DUPUY J BOREL F | 2006 | Cell Cycle2006，5，： | 1 |
| 19 | Influence of processing variables on mechanical characteristics of sunlight aged polyester-glass fiber composites 显示文摘 | SEGOVIA F FERRER C SALVADOR M D AMIGO V | 2001 | Polymer Degradation and Stability2001，71，： | 1 |
| 20 | Pattern of tracheal colonization during mechanical ventilation显示文摘 | deLatorre F J Pont T Ferrer A | | 0，，： | 1 |
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