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| 1 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Early clinical worsening in patients with TIA or minor stroke: The Austrian Stroke Unit Registry显示文摘 | J Ferrari M Knoflach S Kiechl J Willeit S Schnabl L Seyfang W Lang | 2010 | Neurology2010，，2： | 2 |
| 4 | Combined treatment with a β-blocker and intermittent PTH improves bone mass and mieroarehitecture in ovariectomized mice 显示文摘 | Pierroz D D Bouxsein M L Rizzoli R Ferrari S L | 2006 | Bone2006，39，： | 1 |
| 5 | In vivo fractional Pi absorption and NaPi-II mRNA expression in rainbow trout are upregulated by dietary P restriction 显示文摘 | SUGIURA S H McDANIEL N K FERRARIS R P | 2003 | Am J Physiol Regul Integr Comp Physiol2003，285，： | 1 |
| 6 | IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura 显示文摘 | Ferrari S Mudde GC Rieger M | 2009 | J Thromb Haemost2009，7，： | 1 |
| 7 | Polygalacturonase-inhibiting proteins in defense against phytopathogenic fungi显示文摘 | De Lorenzo G Ferrari S | 2002 | Curr Opin Plant Biol2002，5，： | 1 |
| 8 | Novel 7-oxvinlinonlethyl derivalives of camptotheein with polent in vilro and in vivo antitumor activity 显示文摘 | Dallavalle S Ferrari A Biasotti B | 2001 | J Med Chem2001，44，20： | 1 |
| 9 | Hyper immunoglobulin M sydrome due to CD40 deficiency: clinical, molecular, and immunological features 显示文摘 | Lougaris V Badolato R Ferrari S | 2005 | Immunol Rev2005，203，： | 1 |
| 10 | Neoadjuvant chemotherapy forosteosarcoma of the extremity : long-term results of the Rizzoli^ 4thprotocol显示文摘 | Bacci G Briccoli A Ferrari S | 2001 | Eur J Cancer2001，37，16： | 1 |
| 11 | IP-tO in autoimmune thyroiditis 显示文摘 | RUFFILLI I FERRARI S M COLACI M | 2014 | Horm Metab Res2014，46，9： | 1 |
| 12 | Adjuvant combination chemotherapy for osteogenic sarcoma显示文摘 | Ferrari S Palmerini E | 2007 | Curr Opin Oncol2007，19，4： | 1 |
| 13 | Osteosarcoma of the pelvis: a monoinstitutional experience in patients younger than 41 years显示文摘 | Ferrari S Palmerini E Fabbri N | 2012 | Tumori2012，98，6： | 1 |
| 14 | Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study 显示文摘 | Ferrari AJ Ssha S Me Grath JJ | 2012 | Popul Health Metr2012，10，1： | 1 |
| 15 | Neoadjuvant chemothera- py with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the ex- tremity: a joint study by the Italian and Scandinavian Sarcoma Groups 显示文摘 | Ferrari S Smeland S Mercuri M | 2005 | J Clin Oncol2005，23，34： | 1 |
| 16 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 17 | Specifying and Enforcing Access Control Policies for XML Document Sources显示文摘 | BERTINO E CASTANO S FERRARI E | 2000 | World Wide Web Journal2000，3，3： | 1 |
| 18 | Contibutions of different Na/Pi cotransporter isoforms to dietary regulation of P transport in the pyloric caeca and intestine of rainbow trout 显示文摘 | SUGIURA S H FERRARIS R P | 2004 | J Exp Biol2004，207，： | 1 |
| 19 | Laparoscopic myomectomy : technique, complications, and ultrasound scan evaluations 显示文摘 | Landi S Zaccoletti R Ferrari L | 2001 | Jam Assoc Gynecol Laparosc2001，8，2： | 1 |
| 20 | In vitro characterization of coevaporates containing chitosan for colonic drug delivery 显示文摘 | Ferrari P C Oliveira G F Chibebe F C S | 2009 | Carbo Polym2009，78，： | 1 |
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