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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L PrescianottoBaschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 3 | Chitosan -pectin multiparticulate systems associated with enteric polymers for colonic drug delivery显示文摘 | Oliveira G F Ferrari P C Carvalho L Q | 2010 | Carbo Polym2010，82，： | 1 |
| 4 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 5 | Postmortem analysis of formic acid disposition in acute methanol intoxication显示文摘 | FERRARI L A ARADO M G NARDO C A | 2003 | Forensic Sci Int2003，133，12： | 1 |
| 6 | Leptin inhibits steroid biosynthesis by human granulose-lutein cells 显示文摘 | Barreca A Mastorakos G Furlini M Vottero A Ferrari B Chrousos GP Bernasconi S | 2001 | Horm Metab Res2001，33，6： | 1 |
| 7 | The favorable effect of regional citrate anticoagulation on interleukin-1beta release is dissociated from both coagulation and complement activation显示文摘 | Gabutti L Ferrari N Mombelli G | 2004 | J Nephrol2004，17，6： | 1 |
| 8 | Fresh cut Tommy Atkins’ mango pre-treatedwith citric acid and coated with cassava (Manihot esculentaCrantz) starch or sodium alginate 显示文摘 | CHIUMARELLI M FERRARI C C SARANTOPOULOSC I G L | 2011 | Innovative FoodScience & Emerging Technologies2011，12，3： | 1 |
| 9 | Variation in enzyme activities in leaves and cell suspensions as markers of incompatibility in different phytophthora-pepper interactions显示文摘 | Mozzetti C Ferraris L Tamietti G | 1995 | Physiol Mol Plant Pathol1995，46，： | 1 |
| 10 | Induction of apoptosis by fenretinide in tumor cell lines correlated with DLX-2,DLX-3, and DLX-4 gene expression显示文摘 | Ferrari N Paleari L Palmisano G L | 2003 | Oncol Rep2003，10，4： | 1 |
| 11 | Chromium-free catalysts for selective vapor phase hydrogenation of maleic anhydride to γ-butyrolactone显示文摘 | CASTIGLIONI G L FERRARI M GUERCIO A | 1996 | Catal Today1996，27，12： | 1 |
| 12 | Hepatosplenic gamma delta T-cell lymphoma with a novel cytogenetic alteration and cerebrospinal fluid infiltration:biological and clinical features显示文摘 | Ferrari D Girmenia G Migliorini L | 2002 | Haematologica2002，87，3： | 1 |
| 13 | Efficacy of a chemotherapy combination for the treatment of metastatic neuroendocrine tumors 显示文摘 | Bajetta E Ferrari L Procopio G | 2002 | Ann Oncol2002，13，7： | 1 |
| 14 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L Prescianotto-Baschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 15 | Perform- ances of Brazilian IPOs backed by private equity 显示文摘 | Minardi A M Ferrari G L AratjoTavares P C | 2013 | Journal of Business Research2013，66，： | 1 |
| 16 | Exploiting Run-Time Bytecode Manipulation to Add Roles to Java Agents显示文摘 | Cabri G Ferrari L Leonardi L | 2005 | Science of Computer Programming2005，54，1： | 1 |
| 17 | Blood pressure and heart rate variability in normotensive and hypertensive human beings显示文摘 | Mancia G Ferrari A Gregorini L | 1983 | Circ Res1983，53，6： | 1 |
| 18 | Oxidative stress during myocardial ischemia and heart failure 显示文摘 | Ferrari G Agnoletti L Comini L | 1998 | Eur Heart J1998，19，： | 1 |
| 19 | Injecting Roles in Java Agents Through Run-Time Bytecode Manipulation显示文摘 | Cabri G Ferrari L Leonardi L | 2005 | IBM Systems Journal2005，44，1： | 1 |
| 20 | Chromium-free catalysts for selective vapor phase hydrogenation of maleic anhydride toγ-butyrolactone显示文摘 | CASTIGLIONI G L FERRARI M GUERCIO A | 1996 | Catal Today1996，27，： | 1 |
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