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| 1 | 网络能耗系统模型及能效算法显示文摘网络能耗问题是当前网络研究和发展的重要问题,影响着网络的设计、应用和发展.当前网络能效算法的研究大多从网络局部角度关注于网络某一(些)设施的能耗问题,缺乏从网络全局的角度研究网络整体能耗的算法和策略.文中从网络全局角度研究网络的能耗模型和算法问题.文中基于3种基本网络数据传递模式和3种基本网络能耗机制,构建了网络能耗系统优化模型,对其中5种关键系统模型给出了详细的描述.针对几个关键系统模型,文中给出了形式化描述并且提出了相应的优化的节能路由算法.文中给出的网络系统能耗优化模型有助于对于网络能耗的理解和分析,所提出的能耗优化的网络数据包路由算法可以从网络路由的角度有效降低网络能耗. | 张法 Antonio Fernandez Anta 王林 侯晨颖 刘志勇 | 2012 | 计算机学报2012，35，3： | 42 |
| 2 | 预测研究揭示肝硬化急性失代偿具有三个不同病理生理学特征的临床病程显示文摘【据Journal of Hepatology 2020年10月报道】题:预测研究揭示肝硬化急性失代偿具有三个不同病理生理学特征的临床病程(作者Trebicka J等)肝硬化急性失代偿(AD)是指代偿期肝硬化发展至出现腹水、消化道出血、肝性脑病、感染或前述并发症合并发生,需要住院治疗。如AD患者出现器官衰竭,则定义为慢加急性肝衰竭(ACLF)。 | TREBICKA J FERNANDEZ J PAPP M 高沿航 | 2020 | 临床肝胆病杂志2020，36，11： | 25 |
| 3 | 中国和拉美国家经贸发展的机遇和瓶颈显示文摘近年来,中拉经贸合作快速发展。2007年中拉贸易总额历史性地突破1000亿美元,是10年前的10多倍。中拉电信、基础设施建设、能矿、科技等领域投资合作不断取得新进展。但是,在中拉贸易迅速增长过程中,中国进出口产品结构存在明显的地区和行业差异,我国出口增长的势头引起了中南美一些企业的担忧,从而促使其政府对我出口产品采取以反倾销为主的多种贸易救济措施,中拉贸易摩擦问题日益凸显,已经成为双方贸易发展的瓶颈制约。加强沟通,消除贸易摩擦,实现中拉贸易双赢的局面是目前双方急需解决的问题。 | 法南德( Fernandez,Saul Rick | 2009 | 经济师2009，，3： | 21 |
| 4 | 长距离跑后“足外翻”姿态增加膝关节内侧接触力:基于OpenSim肌骨建模及机器学习预测的研究显示文摘目的:揭示跑者在长距离跑后下肢关节的负荷与足姿态的变化及膝关节接触力分布且验证二者关联,为快速预测膝关节负荷提供简易手段。方法:运用OpenSim个体化肌骨建模分析业余跑者5 km跑后下肢关节的运动学、动力学及膝关节接触力变化,采用一维统计参数映射(Statistical Parametric Mapping 1d)分析法检测差异性,结合足姿态参数与膝关节总接触力及膝关节内外侧接触力训练并检验机器学习算法。结果:1)5 km跑后,髋关节蹬离期伸角度、支撑初期外旋角度及踝关节蹬离期跖屈角度均显著增大;2)髋关节支撑期伸力矩及支撑初期外展力矩、踝关节支撑期跖屈力矩均显著增大,膝关节支撑初期及蹬离期屈力矩均显著降低;3)膝关节蹬离期总接触力显著减小,支撑初期内侧接触力显著增大而支撑初期及蹬离期外侧接触力均显著减小;4)机器学习算法模型发现,足外翻程度增大引起膝关节总接触力及内侧接触力快速增大而外侧接触力逐步减小。结论:1)长距离跑后下肢关节负荷出现幅值及重新分布的变化,表现出增大的髋关节伸及外展力矩,减小的膝关节屈力矩及增大的踝关节跖屈力矩,可能与足姿态变化及相关肌群肌力有关;2)长距离跑后膝关节内侧接触力快速增大且与量化的足姿态参数呈线性关系;3)通过足姿态参数指标可快速预测膝关节接触力的变化,跑者可实地评估足姿态参数以预测膝关节负荷的幅值和分布变化,辅助科学合理的安排跑量及训练计划,降低跑步相关的膝关节损伤风险。 | 梅齐昌 相亮亮 孙冬 李建设 Justin Fernandez 顾耀东 | 2019 | 体育科学2019，39，9： | 12 |
| 5 | 基于影像学构建个体化OpenSim下肢肌骨模型的生物力学研究应用进展显示文摘由于OpenSim肌骨系统模拟平台开源性,近年来快速发展且被大量研究使用。个体化OpenSim肌骨模型可计算基础的运动学与动力学数据,揭示神经肌肉控制、肌肉力量和几何学变化及关节接触力等信息;结合影像学建模分析病理步态的神经肌肉控制及辅具的人机工效学评估等研究均表明其应用的可靠性与可行性,但存在耗时及足踝关节模拟的局限性。构建个体化病理肌骨模型,能提升临床生物力学及医学工程学研究的精准性和多样性,揭示不同病理特点,并为制定精准的诊断与康复方案、健康监测与评估状况及外部装置的工效学定制与测评提供科学依据,以及为未来该领域研究提供启示与方向。 | 梅齐昌 顾耀东 孙冬 李建设 Justin FERNANDEZ | 2020 | 医用生物力学2020，35，2： | 8 |
| 6 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 8 |
| 7 | Spatio-temporal Fragmentation of Leisure Activities in Information Era: Empirical Evidence from Nanjing, China显示文摘Activity fragmentation provides a new approach for understanding the transformation of urban space and function in the information era. Numerous theoretical and empirical studies have been conducted on activity fragmentation, but few studies have focused on the fragmentation of leisure activities. This study was intended to extend the extant literature by: 1) analysing the spatio-temporal fragmentation of physical and virtual leisure activities by using a dataset collected in Nanjing, China, and 2) evaluating the reasons of leisure activity fragmentation, as well as the potential spatial effect of activity fragmentation. The results indicated that virtual leisure activities are more fragmented than physical leisure activities, but the fragmentation of physical and virtual leisure activities varies on weekday and weekend, as well as in various locations and urban districts. In addition, the results suggested that sociodemographic factors and information and communication technology(ICT) variables distinctly affect the fragmentation of leisure activities. Meanwhile, the fragmentation of virtual leisure activities may enhance the transformation of traditional urban space by reallocating leisure activity times and locations. | XI Guangliang ZHEN Feng Puel GILLES Fernandez VALERIE | 2017 | Chinese Geographical Science2017，27，1： | 8 |
| 8 | Diabetic heart disease:A clinical update显示文摘Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular complications.Diabetic heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with DM.Pathogenic mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among nondiabetics.Higher prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature death.Although common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac complications.Structural and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing CAN.Similarly,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart disease.Though optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many reasons.Therefore,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among patients.This clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease. | Jake Rajbhandari Cornelius James Fernandez Mayuri Agarwal Beverly Xin Yi Yeap Joseph M Pappachan | 2021 | World Journal of Diabetes2021，12，4： | 8 |
| 9 | 满足新版IEC1000-3-2标准规定(2000版)的单相LC滤波整流器的设计显示文摘本文对用于满足新版IEC10 0 0 3 2 (第二版 )电流谐波限制标准规定的单相全桥LC滤波整流器进行了分析和设计。结果表明 ,如果设计适当的滤波电感值 ,本文所述的无源功率因数校正方法可以满足标准所要求的规定。本文分析了新版IEC10 0 0 3 2标准中划分为A类和D类电力电子产品满足标准规定的条件情况。计算机仿真和实验验证理论分析和计算结果。 | 林维明 Javier Sebastián A Fernandez | 2002 | 电工电能新技术2002，21，2： | 7 |
| 10 | 基于一维统计参数映射分析跑者跑步地面反作用力差异显示文摘目的通过一维统计参数映射(statistical parametric mapping,SPM)对比分析男、女性跑者及左右侧地面反作用力(ground reaction force,GRF)差异。方法30名男、女性跑者在测力跑台上以12 km/h速度进行跑步测试,记录连续5个支撑期GRF,采用一维统计参数映射独立样本t检验与配对样本t检验分别对比男、女性跑者及左右侧GRF差异。结果男、女性跑者的垂直平均负荷加载率(vertical average loading rate,VALR)左右侧均存在不对称,且男性跑者左侧VALR显著高于女性,而右侧无显著差异;男女性跑者右侧垂直GRF在蹬离期及横向GRF在落地期存在差异,男、女性跑者左侧横向GRF在落地期及支撑中期存在差异;男性跑者左右侧前后GRF在蹬离期、垂直GRF在落地和蹬离期及横向GRF在落地期均在存在差异;女性跑者左右侧GRF仅在垂直方向的落地期和蹬离期存在差异。结论介绍SPM在GRF数据分析中的应用,阐释相关步骤及原理,对比SPM连续值检验与特征值检验的差异,并讨论参数性SPM与非参数性SPM的差异与特征,为该方法在运动生物力学研究中的应用提供参考。通过对男、女性跑者间及左右侧GRF对比分析发现在落地期、支撑中期及蹬离期等阶段的性别差异及左右侧对称性差异,相关结果为后续进一步探究跑步相关损伤原理及防治措施铺垫基础。 | 梅齐昌 相亮亮 李建设 Justin FERNANDEZ 顾耀东 | 2021 | 医用生物力学2021，36，5： | 5 |
| 11 | 法国终身教育概要显示文摘 | Bernard Fernandez PhD. | 2001 | 开放教育研究2001，7，1： | 5 |
| 12 | Psychological aspects of diabetes care: Effecting behavioral change in patients显示文摘Patients with diabetes mellitus(DM) need psychological support throughout their life span from the time of diagnosis. The psychological make-up of the patients with DM play a central role in self-management behaviors. Without patient's adherence to the effective therapies, there would be persistent sub-optimal contro of diseases, increase diabetes-related complications,causing deterioration in quality of life, resulting in increased healthcare utilization and burden on healthcare systems. However, provision of psychosocial support is generally inadequate due to its challenging nature of needs and demands on the healthcare systems. This review article examines patient's psychological aspects in general, elaborates in particular about emotion effects on health, and emotion in relation to other psychological domains such as cognition, self-regulation,self-efficacy and behavior. Some descriptions are also provided on willpower, resilience, illness perception and proactive coping in relating execution of new behaviors,coping with future-oriented thinking and influences of illness perception on health-related behaviors. These psychological aspects are further discussed in relationto DM and interventions for patients with DM. Equipped with the understanding of the pertinent nature of psychology in patients with DM; and knowing the links between the psychological disorders, inflammation and cardiovascular outcomes would hopefully encourages healthcare professionals in giving due attention to the psychological needs of patients with DM. | Boon-How Chew Sazlina Shariff-Ghazali Aaron Fernandez | 2014 | World Journal of Diabetes2014，5，6： | 5 |
| 13 | Role of ATG16L,NOD2 and IL23R in Crohn's disease pathogenesis显示文摘Inflammatory bowel disease is a group of diseases that includes Crohn's disease (CD) and ulcerative colitis.CD is characterized as a chronic inflammatory disease of the gastrointestinal tract,ranging from the mouth to the anus.Although there are gross pathological and histological similarities between CD and Johne's disease of cattle,the cause of CD remains controversial.It is vital to understand fully the cause of this disease because it affects approximately 500 000 people in North America and Europe.It ranges from 27 to 48 cases per 100 000 people.There are many theories on the cause of CD ranging from possible association with environmental factors including microorganisms to imbalance in the intestinal normal flora of the patients.Regardless of the environmental trigger,there is strong evidence that a genetic disposition is a major key in acquiring CD.Many studies have proven the link between mutations in the ATG16L,NOD2/CARD15,IBD5,CTLA4,TNFSF15 and IL23R genes,and CD.The purpose of this review is to examine all genetic aspects and theories of CD,including up to date multiple population studies performed worldwide. | Saleh A Naser Melissa Arce Anam Khaja Marlene Fernandez Najih Naser Sammer Elwasila Saisathya Thanigachalam | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 14 | Erythropoietin modulates bone marrow stromal cell differentiation显示文摘Erythropoietin is essential for bone marrow erythropoiesis and erythropoietin receptor on non-erythroid cells including bone marrow stromal cells suggests systemic effects of erythropoietin. Tg6 mice with chronic erythropoietin overexpression have a high hematocrit, reduced trabecular and cortical bone and bone marrow adipocytes, and decreased bone morphogenic protein 2 driven ectopic bone and adipocyte formation. Erythropoietin treatment(1 200 IU·kg–1) for 10 days similarly exhibit increased hematocrit,reduced bone and bone marrow adipocytes without increased osteoclasts, and reduced bone morphogenic protein signaling in the bone marrow. Interestingly, endogenous erythropoietin is required for normal differentiation of bone marrow stromal cells to osteoblasts and bone marrow adipocytes.ΔEpoR_E mice with erythroid restricted erythropoietin receptor exhibit reduced trabecular bone, increased bone marrow adipocytes, and decreased bone morphogenic protein 2 ectopic bone formation. Erythropoietin treated ΔEpoR_E mice achieved hematocrit similar to wild-type mice without reduced bone, suggesting that bone reduction with erythropoietin treatment is associated with non-erythropoietic erythropoietin response. Bone marrow stromal cells from wild-type,Tg6, and ΔEpoR_E-mice were transplanted into immunodeficient mice to assess development into a bone/marrow organ. Like endogenous bone formation, Tg6 bone marrow cells exhibited reduced differentiation to bone and adipocytes indicating that high erythropoietin inhibits osteogenesis and adipogenesis, while ΔEpoR_E bone marrow cells formed ectopic bones with reduced trabecular regions and increased adipocytes, indicating that loss of erythropoietin signaling favors adipogenesis at the expense of osteogenesis. In summary, endogenous erythropoietin signaling regulates bone marrow stromal cell fate and aberrant erythropoietin levels result in their impaired differentiation. | Sukanya Suresh Luis Fernandez de Castro Soumyadeep Dey Pamela G. Robey Constance Tom Noguchi | 2019 | Bone Research2019，7，3： | 5 |
| 15 | Role of colonoscopy in the diagnostic work-up of bowel endometriosis显示文摘AIM:To evaluate the accuracy of colonoscopy for the prediction of intestinal involvement in deep pelvic endometriosis.METHODS:This prospective observational study was performed between September 2011 and July 2014.Only women with both a clinical and imaging diagnosis of deep pelvic endometriosis were included.The study was approved by the local ethics committee and written informed consent was obtained in all cases.Both colonoscopy and laparoscopy were performed by expert surgeons with a high level of expertise with these techniques.Laparoscopy was performed within4 wk of colonoscopic examination.All hypothetical colonoscopy findings(eccentric wall thickening with or without surface nodularities and polypoid lesions with or without surface nodularities of endometriosis)were compared with laparoscopic and histological findings.We calculated the sensitivity,specificity,positive predictive value and negative predictive value for the presence of colonoscopic findings of intestinal endometriosis.RESULTS:A total of 174 consecutive women aged between 21-42 years with a diagnosis of deep pelvic endometriosis who underwent colonoscopy andsurgical intervention were included in our analysis.In 76 of the women(43.6%),intestinal endometrial implants were found at surgery and histopathological examination.Specifically,38 of the 76 lesions(50%)were characterized by the presence of serosal bowel nodules;28 of the 76 lesions(36.8%)reached the muscularis layer;8 of the 76 lesions(10.5%)reached the submucosa;and 2 of the 76 lesions(2.6%)reached the mucosa.Colonoscopic findings suggestive of intestinal endometriosis were detected in 7 of the174(4%)examinations.Colonoscopy failed to diagnose intestinal endometriosis in 70 of the 76 women(92.1%).A colonoscopic diagnosis of endometriosis was obtained in all cases of mucosal involvement,in 3of 8 cases(37.5%)of submucosal involvement,in no cases of muscularis layer involvement and in 1 of 38cases(2.6%)of serosa involvement.The sensitivity,specificity,positive predictive and negative predictive values of colonoscopy for the diagnosis of intestinal endometriosis were 7%,98%,85%and 58%,respectively.CONCLUSION:Being an invasive procedure,colonoscopy should not be routinely performed in the diagnostic work-up of bowel endometriosis. | Marco Milone Antonio Mollo Mario Musella Paola Maietta Loredana Maria Sosa Fernandez Olena Shatalova Alessandro Conforti Gianni Barone Giuseppe De Placido Francesco Milone | 2015 | World Journal of Gastroenterology2015，21，16： | 5 |
| 16 | Varicocele repair in severe oligozoospermia: A case report of post-operative azoospermia显示文摘Varicocele has been implicated as a cause in 35%-50% of patients with primary infertility and up to 81% of men with secondary infertility. Although a large number of reports have shown improvement in the semen parameters after correction of varicocele, other studies have suggested no benefit. We report the first case of azoospermia after surgery in a young infertile male patient with left-sided varicocele and severe oligozoospermia undergoing laparoscopic varicocelectomy. A pregnancy was only achieved with assisted reproductive technology because semen cryopreservation was performed before surgery. In the light of the above, the deterioration of sperm count after varicocele repair in patients with severe oligozoospermia could be due to irreversible impairment of spermatogenesis of such patients, together with the possible temporary damage of the surgical repair. This possible complication could therefore turn the severe oligozoospermia into an indication to perform cryopreservation before surgery, on both clinical and medico-legal grounds. Further research is needed before drawing definitive conclusions regarding the management of varicocele-related severe oligozoospermia. | Marco Milone Mario Musella Miguel Emilio Sosa Fernandez Paola Maietta Annarita Sasso Loredana Maria Sosa Fernandez Laura Virginia Sosa Fernandez Francesco Milone | 2014 | World Journal of Clinical Cases2014，2，4： | 4 |
| 17 | DIRECT NUMERICAL SIMULATIONS OF MULTIPHASE FLOWS显示文摘Direct numerical simulations have recently emerged as a viable tool to study finite Reynolds number multiphase flows. The approach parallels direct numerical simulations of turbulent flows, but the unsteady motion of a deformable phase boundary adds considerable complexity. Here, a front tracking method that has been used to study several multiphase flow problems is described. The Navier Stokes equations are solved by a finite difference/front tracking technique that allows the inclusion of fully deformable interfaces and surface tension, in addition to inertial and viscous effects. A parallel version of the method makes it possible to use large grids and resolve flows containing a few hundred bubbles. | G. Tryggvason A. Esmaeeli A. Fernandez J. LuDepartment of Mechanical Engineering, Worcester Polytechnic Institute, 100 InstituteRoad, Worcester, MA 01609, USA | 2001 | Transactions of Nanjing University of Aeronautics and Astronautics2001，18，z1： | 4 |
| 18 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 19 | 麦角硫因或可降低心血管疾病发生及死亡风险显示文摘目的近期研究发现一种健康饮食模式(HCFP)与降低心脏代谢疾病风险相关,但导致这种相关性的分子机制尚不明确。该研究旨在发现与这种饮食模式相关的血浆代谢物,并研究其与心脏代谢疾病发生和死亡风险的相关性。方法从全人群马尔默饮食和癌症研究中,筛选出3236名无心血管疾病和糖尿病史的参与者。运用液相色谱-质谱法对他们的112种血浆代谢物进行检测。通过多元线性回归和Bonfcrroni校正分析,发现其中与该饮食模式相关的代谢物。使用多变量Cox比例风险模型进行长期随访分析后,发现这些健康饮食的生物标志物与心脏代谢疾病的发生和死亡风险相关。结果平均随访21.4年期间,603人患心血管疾病,362人患糖尿病,843人死亡。基线资料中,5种健康饮食标志物与该饮食模式相关(P<0.0004),其中4种与至少一项研究终点相关(P<0.05)。麦角硫因是与该饮食模式相关性最强的代谢物,并且与降低冠心病风险(危害比0.85,P=0.01)、心血管死亡风险(危害比0.79,P=0.002)、全因死亡风险(麦角硫因每增加一个标准差的危害比,危害比0.86,P=4e-5)相关。结论我们发现高麦角硫因含量是降低心脏代谢疾病发生和死亡风险的独立标志物。而这种高含量很可能是由某种特殊的饮食方式造成的。 | Einar Smith Filip Ottosson Sophie Hellstrand Ulrika Ericson Marju Orho-Melander Celine Fernandez Olle Melander 冯博(译) | 2020 | 英国医学杂志中文版2020，23，4： | 4 |
| 20 | A mini review on two-dimensional nanomaterial assembly显示文摘Two-dimensional(2D)nanomaterials have attracted a great deal of attention since the discovery of graphene in 2004,due to their intriguing physicochemical properties and wide-ranging applications in catalysis,energy-related devices,electronics and optoelectronics.To maximize the potential of 2D nanomaterials for their technological applications,controlled assembly of 2D nanobulding blocks into integrated systems is critically needed.This mini review summarizes the reported strategies of 2D materials-based assembly into integrated functional nanostructures,from in-situ assembly method to post-synthesis assembly.The applications of 2D assembled integrated structures are also covered,especially in the areas of energy,electronics and sensing,and we conclude with discussion on the remaining challenges and potential directions in this emerging field. | Zhiwei Fang Qiyu Xing Desiree Fernandez Xiao Zhang Guihua Yu | 2020 | Nano Research2020，13，5： | 4 |
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