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12篇 您的检索式：作者名="Fernandes LB"

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		题名	作者	年代	出处	被引量
	1	Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments.	Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen	2019	World Journal of Gastroenterology2019，25，33：	3
	2	JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death显示文摘	Fernandes KA Harder JM Fornarola LB	2012	Neurobiol Dis2012，46，：	1
	3	Body position and obstructive sleep apnea in children显示文摘	Fernandes LB Li X Thompson R	2002	Sleep2002，25，：	1
	4	A functional electric orthesis on the paretic leg improves quality of stroke patients显示文摘	Caravalho LB Prado GF	2006	Arq Neuropsiquiatr2006，64，1：	1
	5	Body position and obstructive sleep apnea in children显示文摘	Li X Thompson R	2002	Sleep2002，25，1：	1
	6	Langerhans cellshistiocytosis with vulvar involvement and responding to ihalido-mide therapy--case report 显示文摘	Fernandes LB Guerra JG Costa MB	2011	An Bras Dermatol2011，86，41：	1
	7	Langerhans cells histiocytosis with vulvar involvement and responding to thalidomide therapy--case report 显示文摘	Fernandes LB Guerra JG Costa MB	2011	An Bras Dermatol2011，86，41：	1
	8	Bronchodila- tor response as a hallmark of uncontrolled asthma: a ran- domised clinical trial显示文摘	Fernandes AG Amorim MM Caetano LB	2014	J Asthma2014，51，4：	1
	9	JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death显示文摘	Fernandes KA Harder JM Fornarola LB Freeman RS Clark AF Pang IH		0，，02：	1
	10	Low-temperature synthesis of single-phase crystalline LaNiO3 perovskite via Pechini method 显示文摘	FERNANDES J D G MCLO D M A ZINNER LB	2002	Materials Letters2002，53，12：	1
	11	Jaw-closing muscles:electromyographic activity of human subjects with reduced periodontal support显示文摘	Fernandes CP Psarras V Freitas LB	1994	J Oral Rehabil1994，21，2：	1
	12	A functional electric orthesis on the paretic leg improves quality of life of stroke patients显示文摘	Fernandes MR Carvalbo LB Prado GF	2006	Arq Neuropsiquiatr2006，64，1：	1

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