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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Effect of mitogen-activated protein kinase signal transduction pathway on multidrug resistance induced by vincristine in gastric cancer cell line MGC803显示文摘AIM:To investigate the correlation between mitogen-activated protein kinase (MAPK) signal transduction pathway and multidrug resistance (MDR) in MGC803 cells.METHODS:Western blot was used to analyze the expression of MDR associated gene in transient vincristine (VCR) induced MGC803 cells, which were treated with or without the specific inhibitor of MAPK, PD098059.Morphologic analysis of the cells treated by VCR with or without PD098059 was determined by Wright-Giemsa staining. The cell cycle analysis was performed by using flow cytometric assay and the drug sensitivity of MGC803 cells which were exposed to VCR with or without PD098059 was tested by using MTT assay.RESULTS:Transient exposure to VCR induced P-gp butnot MRP1 or GST-π expression in MGC803 cells and the expression of P-gp was inhibited by PD098059.Apoptotic bodies were found in the cells treated with VCR or VCR+PD098059. FCM results indicated that more MGC803 cells showed apoptotic phenotype when treated by VCR and PD098059 (rate:31.23%) than treated by VCR only (rate:18.42%) (P<0.05).The IC50(284±13.2 μg/L) of MGC803 cells pretreated with VCR was 2.24-fold as that of negative control group (127±17.6μg/L) and 1.48-fold as that of the group treated with PD098059 (191±27.9μg/L).CONCLUSION:This study shows that the expression of P-gp can be induced by transient exposure to VCR and this induction can be prevented by PD098059, which can block the activity of MAPK. MAPK signal transduction pathway may play some roles in modulating MDR1 expression in gastric cancer. | BoChen FengJin PingLu Xiang-LanLu Ping-PingWang Yun-PengLiu FanYao Shu-BaoWang | 2004 | World Journal of Gastroenterology2004，10，6： | 20 |
| 3 | BRF1 ameliorates LPS-induced inflammation through autophagy crosstalking with MAPK/ ERK signaling显示文摘Inflammation is indispensable for host defense,whereas excessive inflammation often develop inflammatory diseases.Autophagy is thought to be engaged in many extracellular stress responses,such as starvation and innate immunity.Thus,autophagy plays an important role in maintaining homeostasis.The purpose of this study was to elucidate the function of BRF1 in the regulation of inflammation and autophagy response in macrophages.We found that BRF1 inhibited the LPS-induced inflammatory factors expression and the autophagy flux in macrophage.Furthermore,inhibition autophagy with 3-MA can attenuate the suppressive effect of BRF1 on LPS-mediated inflammation.In addition,MAPK/ERK signaling pathway was involved in the BRF1 inhibition inflammation and autophagy in macrophages.These findings indicate that BRF1 attenuates LPS-induced inflammatory factors secretion through autophagy,at least in part,through MAPK/ERK signaling pathway. | Weiwei Xie Wei Zheng Min Liu Qizhong Qin Yunpeng Zhao Zhi Cheng Fengjin Guo | 2018 | Genes & Diseases2018，5，3： | 9 |
| 4 | Dust storms evolution in Taklimakan Desert and its correlation with climatic parameters显示文摘在 Taklimakan 的暴风雨发源区域抛弃的沙灰尘附近在 12 个气象学的车站基于沙灰尘暴风雨数据和气候的数据,我们象他们的关联 w 一样从 1960 ~ 2005 | XIAO Fengjin ZHOU Caiping LIAO Yaoming | 2008 | Journal of Geographical Sciences2008，18，4： | 8 |
| 5 | Tropical cyclone hazards analysis based on tropical cyclone potential impact index显示文摘热带气旋,有重降雨和强风的破坏气象学的系统触发了的一个高精力巨大的山崩和暴风,形成重要威胁到沿海的区域。在这份报纸,我们基于热带气旋的空气团轨道,灾难信息,紧张,持续时间,和频率开发了一个热带气旋潜在的影响索引(TCPI ) 。我们在时期上分析了空间模式和 TCPI 的 interannual 变化 19492009,并且作为一个例子拿超级台风 Saomai 检验了在损失,全部的降雨,和最大值弯屈的 TCPI 和直接经济之间的关系速度。结果表明瓷器 TCPI 看起来是在时期上的一个弱减少趋势,它不是重要的在一些时期全面,却重要。在过去的 20 年,当它在浙江,福建和台湾的东南的沿海的省增加了时, TCPI 在海南,广东和 Guangxi 的南部的中国沿海的省减少了。TCPI 的最高的价值主要在台湾被观察,海南,广东和福建和浙江的沿海的区域南部的海岸。TCPI 与直接经济的损失,降雨,和最大的风速度有好关联(P=0.01 ) 。 | XIAO Fengjin YIN Yizhou LUO Yong SONG Lianchun YE Dianxiu | 2011 | Journal of Geographical Sciences2011，21，5： | 5 |
| 6 | High-mobility group protein N2 (HMGN2) inhibited the internalization of Klebsiella pneumoniae into cultured bladder epithelial cells显示文摘因为进主人房间的细菌的侵略是在感染过程的重要的步,使用代理人防碍细菌的成为主观是一条吸引人的途径堵住感染过程。在这个工作,我们在 Klebsiella pneumoniae 感染期间描述人的 cationic 主人防卫肽 HMGN2 的一个新、以前未被认出的角色。我们的结果揭示了 K 的成为主观。进有教养的膀胱的 pneumoniae 紧张 03183 上皮的房间(T24 ) 显著地在是不能的生产任何细菌抑制或杀菌的效果的 HMGN2 集中被减少。用 microarrays 和后续研究,我们证明 HMGN2 影响了 K 的成为主观。由禁止细菌的附件,然后减少的 pneumoniae 紧张 03183 导致细菌的 ERK1/2 激活和肌动朊聚合,它可能贡献细菌的成为主观进 T24 房间。细菌的成为主观的这混乱暗示 HMGN2 能对 K 提供保护。pneumoniae 感染。 | Guixia Wu Yue Cao Bo Fan Fengjin Zheng Xiang Gao Na Liu Xiaokang Liu Ning Huang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 4 |
| 7 | Bone/cartilage organoid on-chip:Construction strategy and application显示文摘The necessity of disease models for bone/cartilage related disorders is well-recognized,but the barrier between ex-vivo cell culture,animal models and the real human body has been pending for decades.The organoid-on-a-chip technique showed opportunity to revolutionize basic research and drug screening for diseases like osteoporosis and arthritis.The bone/cartilage organoid on-chip(BCoC)system is a novel platform of multi-tissue which faithfully emulate the essential elements,biologic functions and pathophysiological response under real circumstances.In this review,we propose the concept of BCoC platform,summarize the basic modules and current efforts to orchestrate them on a single microfluidic system.Current disease models,unsolved problems and future challenging are also discussed,the aim should be a deeper understanding of diseases,and ultimate realization of generic ex-vivo tools for further therapeutic strategies of pathological conditions. | Yan Hu Hao Zhang Sicheng Wang Liehu Cao Fengjin Zhou Yingying Jing Jiacan Su | 2023 | Bioactive Materials2023，，7： | 3 |
| 8 | Preparation of Close-Packed Silver Nanoparticles on Graphene to Improve the Enzyme Immobilization and Electron Transfer at Electrode in Glucose/O2 Biofuel Cell显示文摘在这研究,有拥挤不堪的 AgNPs 结构的化学减少的 graphene 银 nanoparticles 混血儿(AgNPs@CR 去) 被用作一个传导性的矩阵吸附酶并且便于在使不能调动的酶和电极之间的电子转移。准备 AgNPs@CR 去的一条灵巧的线路被设计在 -cyclodextrin 包含(是的 -CD) 减少并且稳定的代理人。AgNPs 的形态学被各种各样的试验性的因素调整并且控制。制作 bioelectrode, AgNPs@CR 去在葡萄糖 oxidase (GOx ) 或 laccase 的固定跟随的玻璃质的碳电极上被修改。它被电气化学的测试表明有拥挤不堪的 AgNPs 的电极提供了装载的高 GOx (=4. | Fengjin Qu Xiaoyan Ma Yuchen Hui Fang Chen Yan Gao | 2017 | Chinese Journal of Chemistry2017，35，7： | 2 |
| 9 | Ability of a Specific ERK Signal-Pathway Inhibitor to Reverse P-Glycoprotein- Mediated Vincristine Resistance in Colon Cancer Cell Unes显示文摘OBJECTIVE To investigate the effect of a specific inhibitor PD098059 of the extracellular-signal regulated protein kinase (ERK) pathway on the P-glycoprotein (P-gp)-mediated resistance of colon cancer cell lines SW480/VCR and CoLo205NCR.METHODS SW480NCR and CoLo205NCR cells were generated byexposuring SW480 and CoLo205 cells to vincristine (VCR) (30 ng/ml) for 72h, which resulted in a comparatively higher level of P-gp expression.Western blotting was used to analyze P-gp, MRP, LRP, GST-'rr and TOPOIIexpression after exposuring the SW480 and CoLo205 cells to VCR (30 ng/ml)for 72 hrs. P-gp and pERK1/2 expressions was analyzed in SW480NCR andCoLo205/VCR cells treated with or without the specific inhibitor of MEK,PD098059. The MTT assay was used to determine the susceptibility ofSW480NCR and CoLo205NCR cells to VCR, treated with or withoutPD098059.I^F.SULI'S The results showed that VCR induced a comparatively higher levelof P-gp expression in the cell lines, but not that of MRP, LRP, GST-n- orTOPOII. P-gp expression levels were depressed significantly in SW480/VCR and COLO205/VCR cells by the specific inhibitor of MEK, PD098059.The IC50 (248 +19.6 and 215 +10.7 ng/ml) to VCR of SW480/VCR andCoLo205/VCR cells exhibited a 2.16 and 2.03-fold higher resistancecompared to the negative control group (SW480 and CoLo205 cells)(115+15.6 and 106 +11.9 ng/ml), but a 1.35 and 1.21 -fold higher resistance thanthe group treated with VCR (30 ng/ml)+ PD098059 (184 + 21.8 and 177+19.4 ng/ml).CONCLUSION This study shows that the expression of P-gp can beinduced by exposuring cells to VCR, and that this induction can be reversedby inhibiting the ERK signaling pathway at the point of MEK by its specificinhibitor, PD098059. The ERK signal-transduction pathway may play a rolein modulating mdrl expression in colon cancer. | FengJin HuaFan BoChen PingLu FanYao HuimianXu ShubaoWang | 2004 | Chinese Journal of Clinical Oncology2004，1，4： | 2 |
| 10 | Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis显示文摘客观: 由于骨质疏松症断裂与臀部在病人的骨头织物调查 osteoprotegerin (OPG ) 和骨破折区别因素(ODF ) 的基因表示。方法: 在在有新潮的骨折(观察员组) 的骨质疏松症患者(超过 50 岁) 的 50 种情况和没有骨质疏松症(控制组) 的新潮的制造患者的 30 个案例中的骨头组织的 OPGmRNA 和 ODFmRNA 与半量的 RT-PCR 方法被分析。结果: ODF 表示的 mRNA, OPG 在有新潮的骨折的病人高是两个。在控制组, OPG mRNA 的表示被观察,当 ODF mRNA 的表示是很细微的时。结论: 年老的病人包括 OPG 包含了所有信号,为导致 osteoclastogenesis 并且支持骨头再吞是必要的 ODF。 | Dan Chen Anmin Chen Fengjin Guo | 2007 | Journal of Nanjing Medical University2007，21，5： | 2 |
| 11 | 骨肉瘤中PTEN蛋白表达及临床意义的研究(英文)显示文摘调查癌症的表示和意义的目的在骨肉瘤的禁止的基因 PTEN 蛋白质。在骨肉瘤的不同组织学的分类分析它的表示的水平。决定为诊断骨肉瘤作为标记基因拿 PTEN 蛋白质的可能性。为了观察 PTEN 的临床的值,表达式为骨肉瘤分类作为一个引用索引铺平。43 个标本从骨肉瘤收集了切除的方法被学习。从操作作为控制组被拿的骨头(骨软骨瘤) 的良性的损害在一样的时期期间收集的 30 个标本。Immunohistochemistry 染色(Elivison™二个步骤方法) 被用来在骨肉瘤的 43 种情况中检测 PTEN 蛋白质的表示。社会科学统计套装软体 10.0 在统计分析被使用。染色的结果 Immunohistochemistry 证明 PTEN 蛋白质的阳性反应都对细胞质面向,它是棕色或微黄色褐的小粒。通过 χ
2 测试,在骨头之间的 PTEN 蛋白质的积极表情的有效差量良性的损害和骨肉瘤(χ
2= 7.976, P <
0.01 ) 被观察。有组织分化的不同的度的骨肉瘤显示出 PTEN 蛋白质的不同水平表示。在区分得好的骨肉瘤之间有有效差量(等级我 II ) 并且糟糕区分的骨肉瘤(等级 III ) 统计上(P <
0.01 ) 。PTEN 的表示的水平否定地被相关到骨肉瘤的组织学的等级。统计上有大意义(r s =−0.4922, P <
0.01 ) 。结论 PTEN 蛋白质可以被用作癌症的候选人基因禁止的基因:PTEN 蛋白质是癌症压制或在骨头肿瘤有表示的基因蛋白质。它可能不仅在肺的癌和神经胶质细胞瘤的学习,而且在骨头肿瘤的学习被使用;PTEN 的表示与骨头肿瘤的亲切和他们区别的度有关。PTEN 的表示断然与区别的度被相关。 | Yubin Wang Anmin Chen Fengjin Guo Yujun Xia | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 2 |
| 12 | Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment显示文摘Rapid and effective repair of injured or diseased bone defects remains a major challenge due to shortages of implants.Smart hydrogels that respond to internal and external stimuli to achieve therapeutic actions in a spatially and temporally controlled manner have recently attracted much attention for bone therapy and regeneration.These hydrogels can be modified by introducing responsive moieties or embedding nanoparticles to increase their capacity for bone repair.Under specific stimuli,smart hydrogels can achieve variable,programmable,and controllable changes on demand to modulate the microenvironment for promoting bone healing.In this review,we highlight the advantages of smart hydrogels and summarize their materials,gelation methods,and properties.Then,we overview the recent advances in developing hydrogels that respond to biochemical signals,electromagnetic energy,and physical stimuli,including single,dual,and multiple types of stimuli,to enable physiological and pathological bone repair by modulating the microenvironment.Then,we discuss the current challenges and future perspectives regarding the clinical translation of smart hydrogels. | Weikai Chen Hao Zhang Qirong Zhou Fengjin Zhou Qin Zhang Jiacan Su 无 | 2023 | Research2023，，4： | 1 |
| 13 | Anterior hybrid decompression and segmental fixation for adjacent three-level cervical spondylosis显示文摘 | Qunfeng Guo Bin Ni Fengjin Zhou | 2011 | Arch Orthop Trauma Surg2011，131，5： | 1 |
| 14 | Effects of icariin on expression of OPN mRNA and type Ⅰ collagen in rat osteoblasts in vitro显示文摘 | XIAO QIANGBING CHEN ANMIN GUO FENGJIN | 2005 | J Huazhong Unir Sci Technolog Med Sci2005，25，6： | 1 |
| 15 | Removal of SO2 from O2-containing flue gas by activated carbon fiber (ACF) impregnated with NH3显示文摘 | LusiXu JiaGuo FengJin ect | 2006 | Chemosphere2006，62，： | 1 |
| 16 | XBP1U inhibits the XBPIS-mediated upregulation of the iNOS gene expression in mammalian ER stress response 显示文摘 | Fengjin G Edward AL Ping L | 2010 | Cell Signal2010，22，： | 1 |
| 17 | An efficient blue-emitting phosphor LiOaPO4 : Eu2+ for white LEDs显示文摘 | WAN Chui-ming MENG Jian-xin ZHANG Fengjin | 2010 | Solid State Communications2010，150，31： | 1 |
| 18 | 不同转移潜能MG63骨肉瘤细胞亚株裸鼠肺转移模型的建立(英文)显示文摘Objective: To establish a nude mice model of human osteosarcoma lung metastasis. Methods: The growth of human osteosarcoma cell sublines M8 and M6 was determined by MTT assay. 2 × 107 cells were injected into the tail vein of nude mice. Mice were sacrificed started on week 4 after injection, and lung metastases were evaluated under both mac-roscopic and microscopic observation with HE staining. Results: The growth of low-metastatic subline M6 was lower than high-metastatic sublines M8. Seventeen mice after injected M8 had occurred lung metastases while only one mice had oc-curred in M6 group. Moreover, M8 cells within metastases were arrangement disorder with variable nuclear hyperchromasia. Conclusion: A mouse model for human osteosarcoma cancer lung metastasis can be established by injection different ability of metastasis MG63 cells into tail vein. | Wentao Zhu Fengjin Guo Tao Xu Anming Chen | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，5： | 1 |
| 19 | Hybrids of collidal silica and waterborne polyurethane 显示文摘 | Yang Chien-Hsin Liu Fengjin Liu Yunpeng | 2006 | Journal of Colloid and Interface Science2006，302，1： | 1 |
| 20 | Bilateral CI laminar hooks combined with C2 pedicle screws fixation for treatment of C1-C2 instability not suitable for placement of transarticular screws显示文摘 | Bin Ni Zhuangchen Zhu Fengjin Zhou | 2010 | Eur Spine J2010，19，8： | 1 |
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