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| 1 | Poor outcomes of immunoglobulin D multiple myeloma patients in the era of novel agents:a single-center experience显示文摘Dear Editor, Multiple myeloma (MM) is a disease characterized by the clonal expansion of malignant plasma cells in the marrow, leading to anemia, hypercalcemia, bone lesion, and renal dysfunction [1]. Immunoglobulin D (IgD) myeloma is a rare subtype of MM, accounting for approximately 1% to 2% of all MM patients [2]. It occurs at a young age, often accom-panied with a high disease burden and short median sur-vival (18-21 months) [3, 4]. Several studies have suggested that in patients with IgD subtype, the outcomes of those who have had undergone autologous stem cell transplanta-tion (ASCT) were superior than those treated with chemo-therapy alone [5, 6]. However, these have been debatable as other reports have displayed opposite results [7, 8]. | Qian Zhao Feng Li Ping Song Xiaogang Zhou Zhiming An Jiangang Mei Jingjing Shao Hanqing Li Xuli Wang Xing Guo Yongping Zhai | 2019 | Cancer Communications2019，39，1： | 3 |
| 2 | Water-soluble fluorescent conjugated polymers and their interactions with biomacromolecules for sensitive biosensors 显示文摘 | Feng Xuli Liu Libing Wang Shu | 2010 | Chem Soc Rev2010，39，7： | 1 |
| 3 | Protein-assisted conjugated polymer microarray: Fabrication and sensing applications显示文摘A new strategy is performed to fabricate conjugated polymer microarray with the assistance of protein in this work.The water-soluble cationic conjugated polymer employed in the present work is capable of absorbing light at 510 nm,which makes it compatible with a variety of commercial microarray scanners.It is demonstrated that the protein-assisted conjugated polymer microarray exhibits higher fluorescence signal and better stability in comparison with the case without protein.The conjugated polymer microarray can be used for sensitive detection of picric acid(PA).A major advantage of our approach is its simplicity and chemical linking is not required between the conjugated polymer and microarray substrate.Considering the simplicity of the preparation of the conjugated polymer microarray,it is anticipated that novel sensing platforms will be constructed by employing this versatile method. | Lü FengTing FENG XuLi LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，33： | 0 |
| 4 | Fast modeling of gravity gradients from topographic surface data using GPU parallel algorithm显示文摘The gravity gradient is a secondary derivative of gravity potential,containing more high-frequency information of Earth’s gravity field.Gravity gradient observation data require deducting its prior and intrinsic parts to obtain more variational information.A model generated from a topographic surface database is more appropriate to represent gradiometric effects derived from near-surface mass,as other kinds of data can hardly reach the spatial resolution requirement.The rectangle prism method,namely an analytic integration of Newtonian potential integrals,is a reliable and commonly used approach to modeling gravity gradient,whereas its computing efficiency is extremely low.A modified rectangle prism method and a graphical processing unit(GPU)parallel algorithm were proposed to speed up the modeling process.The modified method avoided massive redundant computations by deforming formulas according to the symmetries of prisms’integral regions,and the proposed algorithm parallelized this method’s computing process.The parallel algorithm was compared with a conventional serial algorithm using 100 elevation data in two topographic areas(rough and moderate terrain).Modeling differences between the two algorithms were less than 0.1 E,which is attributed to precision differences between single-precision and double-precision float numbers.The parallel algorithm showed computational efficiency approximately 200 times higher than the serial algorithm in experiments,demonstrating its effective speeding up in the modeling process.Further analysis indicates that both the modified method and computational parallelism through GPU contributed to the proposed algorithm’s performances in experiments. | Xuli Tan Qingbin Wang Jinkai Feng Yan Huang Ziyan Huang | 2021 | Geodesy and Geodynamics2021，12，4： | 0 |
| 5 | Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes显示文摘Small-diameter tissue-engineered vascular grafts(sdTEVGs)with hyperglycemia resistance have not been constructed.The intimal hyperplasia caused by hyperglycemia remains problem to hinder the patency of sdTEVGs.Here,inspired by bionic regulation of nerve on vascular,we found the released neural exosomes could inhibit the abnormal phenotype transformation of vascular smooth muscle cells(VSMCs).The transformation was a prime culprit causing the intimal hyperplasia of sdTEVGs.To address this concern,sdTEVGs were modified with an on-demand programmable dual-responsive system of ultrathin hydrogels.An external primary Reactive Oxygen Species(ROS)-responsive Netrin-1 system was initially triggered by local inflammation to induce nerve remolding of the sdTEVGs overcoming the difficulty of nerve regeneration under hyperglycemia.Then,the internal secondary ATP-responsive DENND1A(guanine nucleotide exchange factor)system was turned on by the neurotransmitter ATP from the immigrated nerve fibers to stimulate effective release of neural exosomes.The results showed nerve fibers grow into the sdTEVGs in diabetic rats 30 days after transplantation.At day 90,the abnormal VSMCs phenotype was not detected in the sdTEVGs,which maintained long-time patency without intima hyperplasia.Our study provides new insights to construct vascular grafts resisting hyperglycemia damage. | Yanzhao Li Yeqin Wang Fangchao Xue Xuli Feng Zhaojing Ba Junjie Chen Zhenhua Zhou Yanhong Wang Ge Guan Guanyuan Yang Ziwei Xi Hao Tian Yong Liu Ju Tan Gang Li Xiewan Chen Mingcan Yang Wen Chen Chuhong Zhu Wen Zeng | 2022 | Bioactive Materials2022，7，1： | 0 |
| 6 | Self-gating enhanced carrier transfer in semiconductor electrocatalyst verified in microdevice显示文摘Semiconductor electrocatalysis with weak conductivity can accumulate extremely high carriers at semiconductor-electrolyte interface by self-gating effect,which strongly promotes electrocatalytic efficiency.The correlation between semiconductor carrier mobility and electrocatalysis performance is still unclear.Herein atomic-thin transition metal dichalcogenides based composites have been developed for hydrogen evolution reaction(HER)performed with on-chip microdevices.Electrical and electrochemical measurement of individual flack verified the key role of high carrier mobility for enhanced HER activity.Carrier mobility regulation further demonstrated its high dependence with HER performance under self-gating.Our study provides new insight into the carrier mobility of the semiconductor in the electrocatalysis,paving the way for designing high-performance semiconductor catalysts. | Haiyan Xiang Yueshao Zheng Yang Chen Yanting Xu Travis Shihao Hu Yexin Feng Yu Zhou Song Liu Xuli Chen | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 7 | MDR1-targeted siRNA delivery with cationic dendritic conjugated polymers显示文摘A cationic dendritic polyfluorene (PFP) is examined as a siRNA delivery vector. This material was designed to facilitate the nucleic acid binding, encapsulation and efficient cellular uptake. PFP can effectively protect siRNA against nuclease degradation, which is necessary for gene carriers. PFP can be used for multidrug resistance gene-targeted siRNA delivery in doxorubicin (Dox)-resistant human breast cancer cells (MCF7) cells. As a siRNA transfection agent, PFP can efficiently achieve the reversal of drug resistance and enhance the drug sensitivity. These new features and capabilities represent a major step toward conjugated polymers that can function for therapeutic application. | FENG XuLi Lü FengTing LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，22： | 0 |
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