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| 1 | Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging显示文摘BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus bridging.Overall survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were compared.After TACE,only patients within Milan Criteria(MC)were transplanted.More patients underwent LT in bridging group.Five-year post-transplant overall survival,recurrence-free survival has no difference between the groups.Complete response was observed more frequently in bridging group.Patients in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE.AIM To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs bridging.METHODS Prospective cohort study of 200 patients included from April 2011 through June 2014.Bridging group included patients within MC.Downstaging group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly different.Overall survival and tumor recurrence rates were calculated by the Kaplan-Meier method.Additionally,eligibility for LT,time on the waiting list until LT and radiological response were compared.RESULTS After TACE,only patients within MC were transplanted.More patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant overall survival was 73.5%in downstaging and 72.3%bridging groups(P=0.31),and recurrence-free survival was 62.1%in downstaging and 74.8%bridging groups(P=0.93).Radiological response:complete response was observed more frequently in bridging group(P=0.004).CONCLUSION Tumors initially exceeding the MC down-staged after DEB-TACE,can achieve post-transplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE. | Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker | 2019 | World Journal of Gastroenterology2019，25，37： | 21 |
| 2 | Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease显示文摘AIM: To establish the efficacy and safety of a 7-d therapeutic regimen using omeprazole,bismuth subcitrate,furazolidone and amoxicillin in patients with peptic ulcer disease who had been previously treated with other therapeutic regimens without success.METHODS: Open cohort study which included patients with peptic ulcer who had previously been treated unsuccessfully with one or more eradication regimens.The therapeutic regimen consisted of 20 mg omeprazole,240 mg colloidal bismuth subcitrate,1000 mg amoxicillin,and 200 mg furazolidone,taken twice a day for 7 d.Patients were considered as eradicated when samples taken from the gastric antrum and corpus 12 wk after the end of treatment were negative for Helicobacter pylori (H pylori) (rapid urease test and histology).Safety was determined by the presence of adverse effects.RESULTS: Fifty-one patients were enrolled.The eradication rate was 68.8% (31/45).Adverse effects were reported by 31.4% of the patients,and these were usually considered to be slight or moderate in the majority of the cases.Three patients had to withdraw from the treatment due to the presence of severe adverse effects.CONCLUSION: The association of bismuth,furazolidone,amoxicillin and a proton-pump inhibitor is a valuable alternative for patients who failed to respond to other eradication regimens.It is an effective,cheap and safe option for salvage therapy of positive patients. | Guilherme Eduardo Gonalves Felga Fernando Marcuz Silva Ricardo Correa Barbuti Tomás Navarro-Rodriguez Schlioma Zaterka Jaime Natan Eisig | 2008 | World Journal of Gastroenterology2008，14，40： | 9 |
| 3 | Hepatocellular car- cinoma recurrence among liver transplant recipients within the milan criteria显示文摘 | Felga G Evangelista A S Salvalaggio P R | 2012 | Transplant Proc2012，44，8： | 1 |
| 4 | A full solid diet as the initial meal in mild acute pancreatitis is safe and result in a shorter length of hospitalization:results from a prospective,randomized,controlled,double-blind clinical trial显示文摘 | Moraes JM Felga GE Chebli LA | 2010 | J Clin Gastroenterol2010，44，7： | 1 |
| 5 | Early onset steroid-dependent ulcerative colitis is a predictor of azathioprineresponse : a longitudinal 12-month follow-up study显示文摘 | Chebli LA Felga GG Chaves LD | 2010 | Med SciMonit2010，16，2： | 1 |
| 6 | Liver Transplantation in Latin America: The State-of-the-Art and Future Trends显示文摘 | Paolo R. Salvalaggio Juan C. Caicedo Luiz Carneiro de Albuquerque Alan Contreras Valter D. Garcia Guilherme E. Felga Rafael J. Maurette José O. Medina-Pestana Alejandro Ni?o-Murcia Lucio F. Pacheco-Moreira Juan Rocca Manuel Rodriguez-Davalos Andres Ruf Lu | 2014 | Transplantation2014，，3： | 1 |
| 7 | Hepatocellular carcinoma recurrence among liver transplant recipients within the Milan criteria显示文摘 | Felga G Evangelista AS Salvalaggio PR | 2012 | Transplant Proc2012，44，8： | 1 |
| 8 | A Full Solid Diet as the Initial Meal in Mild Acute Pancreatitis is Safe and Result in a Shorter Length of Hospitalization: Results From a Prospective, Randomized, Controlled, Double-blind Clinical Trial显示文摘 | José Maria Mendes Moraes Guilherme Eduardo Gon?alves Felga Liliana Andrade Chebli Márcio Bousada Franco Carlos Augusto Gomes Pedro Duarte Gaburri Alexandre Zanini Julio Maria Fonseca Chebli | 2010 | Journal of Clinical Gastroenterology2010，，7： | 1 |
| 9 | Update on the management and treatment of viral hepatitis显示文摘This review aims to summarize the current evidence on the treatment of viral hepatitis,focusing on its clinical management.Also,future treatment options and areas of potential research interest are detailed.PubMed and Scopus databases were searched for primary studies published within the last ten years.Keywords included hepatitis A virus,hepatitis B virus(HBV),hepatitis C virus,hepatitis D virus(HDV),hepatitis E virus,and treatment.Outcomes reported in the studies were summarized,tabulated,and synthesized.Significant advances in viral hepatitis treatment were accomplished,such as the advent of curative therapies for hepatitis C and the development and improvement of hepatitis A,hepatitis B,and hepatitis E vaccination.Drugs that cure hepatitis B,going beyond viral suppression,are so far unavailable;however,targeted antiviral drugs against HBV(immunomodulatory therapies and gene silencing technologies)are promising approaches to eradicating the virus.Ultimately,high vaccination coverage and large-scale test-and-treat programmes with high screening rates may eliminate viral hepatitis and mitigate their burden on health systems.The development of curative hepatitis C treatment renewed the enthusiasm for curing hepatitis B,albeit further investigation is required.Novel therapeutic options targeting HDV life cycle are currently under clinical investigation. | Patricia Holanda Almeida Celso E L Matielo Lilian A Curvelo Rodrigo A Rocco Guilherme Felga Bianca Della Guardia Yuri L Boteon | 2021 | World Journal of Gastroenterology2021，27，23： | 1 |
| 10 | Clarithromycin- based triple therapy for Helicobacter pylori treatment in peptic ulcer patients显示文摘 | Felga G Silva FM Barbuti RC | 2010 | J Infect Dev Ctries2010，4，11： | 1 |
| 11 | A full solid diet as the initial meal in mild acute pancreatitis is safe and resultin a shorter length of hospitalization显示文摘 | Moraes JMM Felga GEG Chebli LA | | 0，，07： | 1 |
| 12 | Current and future perspectives on acute-on-chronic liver failure: Challenges of transplantation, machine perfusion, and beyond显示文摘Acute-on-chronic liver failure(ACLF)is a syndrome that occurs in patients with chronic liver disease and is characterized by acute decompensation,organ failure and high short-term mortality.Partially due to the lack of universal diagnostic criteria,the actual ACLF prevalence remains unclear;nevertheless,it is expected to be a highly prevalent condition worldwide.Earlier transplantation is an effective protective measure for selected ACLF patients.Besides liver transplantation,diagnosing and treating precipitant events and providing supportive treatment for organ failures are currently the cornerstone of ACLF therapy.Although new clinical specific therapies have been researched,more studies are necessary to assess safety and efficacy.Therefore,future ACLF management strategies must consider measures to improve access to liver transplantation because the time window for this life-saving therapy is frequently narrow.Thus,an urgent and global discussion about allocation and prioritization for transplantation in critically ill ACLF patients is needed because there is evidence suggesting that the current model may not portray their waitlist mortality.In addition,while donor organ quality is meant to be a prognostic factor in the ACLF setting,recent evidence suggests that machine perfusion of the liver may be a safe tool to improve the donor organ pool and expedite liver transplantation in this scenario. | Bianca Della Guardia Amanda P C S Boteon Celso E L Matielo Guilherme Felga Yuri L Boteon | 2022 | World Journal of Gastroenterology2022，28，48： | 0 |
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