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| 1 | Recent advances in nano scaffolds for bone repair显示文摘Biomedical applications of nanomaterials are exponentially increasing every year due to analogy to various cell receptors, ligands, structural proteins, and genetic materials(that is, DNA). In bone tissue, nanoscale materials can provide scaffold for excellent tissue repair via mechanical stimulation, releasing of various loaded drugs and mediators, 3D scaffold for cell growth and differentiation of bone marrow stem cells to osteocytes. This review will therefore highlight recent advancements on tissue and nanoscale materials interaction. | Huan Yi Fawad Ur Rehman Chunqiu Zhao Bin Liu Nongyue He | 2016 | Bone Research2016，4，4： | 17 |
| 2 | Ibrutinib alleviated LPS-induced neuroinflam⁃mation and synaptic defects in mouse model of depression显示文摘OBJECTIVE Previous studies have demonstrated a close association between an altered immune system and major depressive disorders,and inhibition of neuroinflammation may represent an alternative mechanism to treat depression.Recently,the anti-inflammatory activ⁃ity of ibrutinib has been reported.However,the effect of ibrutinib on neuroinflammation-induced depression and its underlying mechanism has not been comprehensively studied.Therefore,we aimed to elucidate the potential anti-depres⁃sive role and mechanism of ibrutinib against neu⁃roinflammation-induced depression and synaptic defects.METHODS AND RESULTS Ibrutinib treatment significantly reduced lipopolysaccha⁃ride(LPS)-induced depressive-like behaviors and neuroinflammation via inhibiting NF-κB acti⁃vation,decreasing proinflammatory cytokine levels,and normalizing redox signaling and its downstream components,including Nrf2,HO-1,and SOD2,as well as glial cell activation mark⁃ers,such as Iba-1 and GFAP.Further,ibrutinib treatment inhibited LPS-activated inflammasome activation by targeting NLRP3/P38/caspase-1 signaling.Interestingly,LPS reduced the number of dendritic spines and expression of BDNF,and synaptic-related markers,including PSD95,snap25,and synaptophysin,were improved by ibrutinib treatment in the hippocampal area of the mouse brain.CONCLUSION Ibrutinib can allevi⁃ate neuroinflammation and synaptic defects,sug⁃gesting it has antidepressant potential against LPS-induced neuroinflammation and depression. | LI Wei-fen Tahir Ali HE Kai-wu LIU Zi-zhen Fawad Ali Shah REN Qing-guo LIU Yan JIANG An-long LI Shu-peng | 2021 | 中国药理学与毒理学杂志2021，35，9： | 10 |
| 3 | Association between facet joint osteoarthritis and the Oswestry Disability Index显示文摘AIM:To investigate the correlation of facet joint osteoarthritis(FJOA) at lumbar levels L4/L5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS:The study involved lumbar MRIs of 591 patients with a mean age of 47.3 years.The MRIs of the lumbar spine were performed on a 1.5 Tesla scanner(Magnetom Avanto,Siemens AG,Erlangen,Germany) using a dedicated receive only spine coil.After initial blinding,each dataset was evaluated by 2 board certified radiologist with more than 5 years experience in musculoskeletal imaging.In total 2364 facet joints were graded.Degenerative changes of the facet joints were evaluated according to the 4-point scale as proposed by Weishaupt et al Functional status was assessed using the ODI.The index is scored from 0 to 100 and interpreted as follows:0%-20%,minimaldisability; 20%-40%,moderate disability; 40%-60%,severe disability; 60%-80%,crippled; 80%-100%,patients are bedbound.Spearman's coefficient of rank correlation was used for statistical analysis,with significance set at P < 0.05.RESULTS:In total 2364 facet joints at lumbar levels L4/5 and L5/S1 were analysed in 591 individuals.FJOA was present in 97%(L4/L5) and 98%(L5/S1).At level L4/5(left/right) 17/15(2.9%/2.5%) were described as grade 0,146/147(24.7%/24.9%) as grade 1,290/302(49.1%/51.1%) as grade 2 and 138/127(23.4%/21.5%) as grade 3.At level L5/S1(left/right) 10/11(1.7%/1.9%) were described as grade 0,136/136(23.0%/23.0%) as grade 1,318/325(53.8%/55.0%) as grade 2 and 127/119(21.5%/20.1%) as grade 3.Regarding the ODI scores,patients' disability had a minimum of 0% and a maximum of 91.11% with an arithmetic mean of 32.77% ± 17.02%.The majority of patients(48.39%) had moderate functional disability(21%-40%).There was no significant correlation between FJOA and ODI on both sides of lumbar level L4/5 and on the left side of lumbar level L5/S1.A weak positive correlation was evaluated between ODI and FJOA on the right side of lumbar level L5/S1.CONCLUSION:The missing correlation of FJOA and ODI confirms our clinical experience that imaging alone is an insufficient approach explaining low back pain.Clinical correlation is imperative for an adequate diagnostic advance in patients with low back pain. | Adel Maataoui Thomas J Vogl Marcus Middendorp Konstantinos Kafchitsas M Fawad Khan | 2014 | World Journal of Radiology2014，6，11： | 6 |
| 4 | Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms显示文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS. | Annina SplettstoBer M Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann Marcus Middendorp Adel Maataoui | 2017 | World Journal of Radiology2017，9，5： | 4 |
| 5 | Magnetic resonance imaging-based interpretation of degenerative changes in the lower lumbar segments and therapeutic consequences显示文摘Intervertebral disc degeneration and facet joint osteoarthritis of the lumbar spine are, among others, wellknown as a cause of low back and lower extremity pain. Together with their secondary disorders they set a big burden on health care systems and economics worldwide. Despite modern imaging modalities, such as magnetic resonance imaging, for a large proportion of patients with low back pain(LBP) it remains difficult to provide a specific diagnosis. The fact that nearly all the lumbar structures are possible sources of LBP, may serve as a possible explanation. Furthermore, our clinical experience confirms, that imaging alone is not a sufficient approach explaining LBP. Here, the Oswestry Disability Index, as the most commonly used measure to quantify disability for LBP, may serve as an easy-toapply questionnaire to evaluate the patient's ability to cope with everyday life. For therapeutic purposes, among the different options, the lumbar facet joint intraarticular injection of corticosteroids in combination with an anaesthetic solution is one of the most frequently performed interventional procedures. Although widely used the clinical benefit of intra-articular steroid injections remains controversial. Therefore, prior to therapy, standardized diagnostic algorithms for an accurate assessment, classification and correlation of degenerative changes of the lumbar spine are needed. | Adel Maataoui Thomas J Vogl M Fawad Khan | 2015 | World Journal of Radiology2015，7，8： | 4 |
| 6 | Effect of acid etching on marginal adaptation of mineral trioxide aggregate to apical dentin:microcomputed tomography and scanning electron microscopy analysis显示文摘The present investigation assessed the effect of acid etching on marginal adaptation of white- and gray-colored mineral trioxide aggregate (MTA) to apical dentin using microcomputed tomography (micro-CT) and scanning electron microscopy (SEM). Sixty-four extracted single-rooted human maxillary teeth were used. Following root-end resection and apical preparation, the teeth were equally divided into four groups according to the following root end filling materials: (i) white-colored MTA (WMTA), (ii) etched WMTA (EWMTA), (iii) gray-colored MTA (GMTA) and (iv) etched GMTA (EGMTA). After 48 h, the interface between root-end filling materials and the dentinal walls was assessed using micro-CT and SEM. Data were statistically analyzed using the Kruskal-Wallis and Dunn tests. Micro-CT analysis revealed gap volumes between the apical cavity dentin walls and EGMTA, GMTA, EWMTA and WMTA of (0.007 160.004) mm 3 , (0.05360.002) mm 3 , (0.003 660.001) mm 3 and (0.005 960.002) mm 3 respectively. SEM analysis revealed gap sizes for EGMTA, WMTA, EWMTA and GMTA to be (492.3613.8) mm, (594.5617.12) mm, (543.1615.33) mm and (910.7626.2) mm respectively. A significant difference in gap size between root end preparations filled with GMTA and EGMTA was found (P,0.05). No significance difference in gap size between WMTA and EWMTA were found in either SEM or micro-CT analysis. In conclusion, pre-etching of apical dentin can provide a better seal for GMTA but not for WMTA. | Khalid Al-Fouzan Ziad Al-Garawi Khalid Al-Hezaimi Fawad Javed Thakib Al-Shalan Ilan Rotstein | 2012 | International Journal of Oral Science2012，4，4： | 3 |
| 7 | Real-time-guided bone regeneration around standardized critical size calvarial defects using bone marrow-derived mesenchymal stem cells and collagen membrane with and without using tricalcium phosphate: an in vivo microcomputed tomographic and histologic e显示文摘The aim of the present real time in vivo micro-computed tomography(m CT)and histologic experiment was to assess the efficacy of guided bone regeneration(GBR)around standardized calvarial critical size defects(CSD)using bone marrow-derived mesenchymal stem cells(BMSCs),and collagen membrane(CM)with and without tricalcium phosphate(TCP)graft material.In the calvaria of nine female Sprague-Dawley rats,full-thickness CSD(diameter 4.6 mm)were created under general anesthesia.Treatment-wise,rats were divided into three groups.In group 1,CSD was covered with a resorbable CM;in group 2,BMSCs were filled in CSD and covered with CM;and in group 3,TCP soaked in BMSCs was placed in CSD and covered with CM.All defects were closed using resorbable sutures.Bone volume and bone mineral density of newly formed bone(NFB)and remaining TCP particles and rate of new bone formation was determined at baseline,2,4,6,and 10 weeks using in vivo m CT.At the 10th week,the rats were killed and calvarial segments were assessed histologically.The results showed that the hardness of NFB was similar to that of the native bone in groups 1 and 2 as compared to the NFB in group 3.Likewise,values for the modulus of elasticity were also significantly higher in group 3 compared to groups 1 and 2.This suggests that TCP when used in combination with BMSCs and without CM was unable to form bone of significant strength that could possibly provide mechanical'lock'between the natural bone and NFB.The use of BMSCs as adjuncts to conventional GBR initiated new bone formation as early as 2 weeks of treatment compared to when GBR is attempted without adjunct BMSC therapy. | Khalid Al-Hezaimi Sundar Ramalingam Mansour Al-Askar Aws S ArRejaie Nasser Nooh Fawad Jawad Abdullah Aldahmash Muhammad Atteya Cun-Yu Wang | 2016 | International Journal of Oral Science2016，8，1： | 2 |
| 8 | In-situ green synthesis of highly active GSH-capped Pt–Au–Ag-hybrid nanoclusters显示文摘Recently much attention has been paid to the application of metal hybrid nanoparticles in industrial catalytic fields because of their super-efficient catalytic activity and attractive properties. We explored a novel strategy to prepare GSH-capped Pt–Au–Ag-hybrid nanoclusters through the synergistic effect between ascorbic acid(VC) and glutathione(GSH) with chloroplatinic acid, chloroauric acid, and silver nitrate as precursors. The potential utilization of as-prepared GSH-capped Pt–Au–Aghybrid nanoclusters for catalytic applications has been evaluated through the reduction of 4-nitrophenol(4-NP) with NaBH4; we obtained the kinetic data by monitoring with UV-Vis spectroscopy. Our results illustrate that GSH-capped Pt–Au– Ag-hybrid nanoclusters could facilitate the process of reduction of 4-NP in a way that is unprecedented. This approach may offer a novel, non-cytotoxicity, efficient catalyst for industry. | CHEN DongHua GAO ShengPing UR REHMAN Fawad JIANG Hui WANG XueMei | 2014 | Science China Chemistry2014，57，11： | 2 |
| 9 | HCV genotype distribution and possible transmission risks in Lahore, Pakistan显示文摘AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes and their association with possible transmission routes in the general population of Lahore, as the data exclusively related to this city is limited. METHODS: Complete data regarding patient's history, possible route of infection and biochemical tests was collected from the public hospital for 1364 patients. SPSS version 16 windows software was used for data analysis by univariate and multivariate techniques. RESULTS: Age range ≤ 40 years showed high prevalence of HCV infection. HCV genotype 3a was dominant (55.9%), followed by 1a (23.6%), 4a (12.5%), 3b (3.2%), untypable (2.5%), 4b (1.2%) and mixed type (1.2%). Blood transfusion, dental surgery and barber shops were the main risk factors for HCV transmission. Genotype prevalence was independent of age (P = 0.971) and gender (P = 0.122) while risk factors showed a significant association with age (P = 0.000) and genotypes (P = 0.000). We observed an independent association of risk factors and genotype 3a, while patients with genotype 1 and 4 were mostly infected due to dental surgery blood transfusion and barber shops. Risk factors of intravenous drug use and sexual exposure were exclusively found in ≤ 40 years age group. CONCLUSION: An increase in genotypes 1a and 4a suggest migration of people, possibly from Balochistan and the northern war-zone area. Government should focus on public education regarding infection routes. | Waqar Ahmad Bushra Ijaz Fouzia Tahir Javed Shah Jahan Imran Shahid Fawad Mumtaz Khan Sajida Hassan | 2010 | World Journal of Gastroenterology2010，16，34： | 2 |
| 10 | Synthesis and Biological Evaluation of Quinazolonethiazoles as New Potential Conquerors towards Pseudomonas Aeruginosa显示文摘Novel quinazolonthiazoles were designed and synthesized as new potential antimicrobial agents by facile multi-step procedure from o-aminobenzoic acids and 2-acetylthiazole.A series of biological evaluation showed that compound 7d was the most effective quinazolonethiazole with superior activity to reference drugs chloramphenicol and norfloxacin.This active molecule displayed unob-vious bacterial resistance against P.aeruginosa,the low toxicity to normal hepatocytes,suitable pharmacokinetics and drug-likeness.The preliminary biological interaction suggested that quinazolonethiazole 7d might induce bacterial death by disturbing the membrane permeability,whilst preventing bacteria from growth by integrating into DNA and binding with topoisomerase IV.These findings provided significant background for the further development of quinazolonethiazoles as new potential drugs in combating drug-resistant pathogens. | Jie Wang Narsaiah Battini Mohammad Fawad Ansari Cheng-He Zhou | 2021 | Chinese Journal of Chemistry2021，39，5： | 2 |
| 11 | Virtual endoscopy of the tracheo-bronchial system: sub-millimeter collimation with the 16-row multidetector scanner显示文摘 | M. Fawad Khan Christopher Herzog Hanns Ackermann Thomas O. F. Wagner Adel Maataoui Marc Harth Nasreddin D. Abolmaali Volkmar Jacobi Thomas J. Vogl | 2004 | European Radiology2004，，： | 1 |
| 12 | Peri-implant Diseases显示文摘 | Georgios E. Romanos Fawad Javed Rafael Arcesio Delgado-Ruiz José Luis Calvo-Guirado | 2015 | Dental Clinics of North America2015，，： | 1 |
| 13 | Maternal morbidity and mortality due to primary PPH-experience at Ayub Teach- ing Hospital Abbottabad 显示文摘 | Naz H Sarwar I Fawad A | 2008 | J Ayub Med CollAbbottabad2008，20，2： | 1 |
| 14 | 叶子花和斑叶三角花的植物化学和体外抗微生物活性的比较研究(英文)显示文摘AIM: To study the qualitative analysis of phytochemicals and antibacterial activity of the ethanolic and methanolic extracts of Bougainvillea spectabilis and Bougainvillea variegata leaves. METHODS: Phytochemical constituents were determined qualitatively by the Harborne method, while antimicrobial activities were determined by measuring the zone of inhibition on Mueller Hinton Agar. RESULTS: The maximum inhibitory effects were obtained against the Gram positive microbe Staphylococcus aureus for the methanolic extracts of both B. spectabilis [(28.54 ± 0.18) mm] and B. variegata [(21.97 ± 0.06) mm]. The Gram negative microbes Proteus vulgaris [(16.00 ± 0.15) mm] and Serratia marcescens [(16.00 ± 0.06) mm] gave maximum inhibitory effects for the ethanolic extracts of B. variegata, while Salmonella typhimurium [(17.26 ± 0.12) mm] gave a maximum zone of inhibition for the methanolic extract of B. spectabilis.No inhibitory effects were observed for the extracts of B. spectabilis or B. variegate against Enterococcus faecalis, Vibro cholera or Klebsiella pneumoniae. CONCLUSION: Both B. spectabilis and B. variegata possess significant antimicrobial activity that, following additional studies, could replace commercially known antibiotics. | Sardar Atiq Fawad Nauman Khalid Waqas Asghar Hafiz Ansar Rasul Suleria | 2012 | 中国天然药物2012，10，6： | 1 |
| 15 | Investiga- tion into microstructures of maraging steel 250 weldments and effect of post-weld heat treatments 显示文摘 | FAWAD T BALOCH R A AHMED B | 2010 | Journal of Ma- terials Engineering and Performance2010，19，2： | 1 |
| 16 | Design and Synthesis of Sulfanilamide Aminophosphonates as Novel Antibacterial Agents towards Escherichia coli显示文摘The limit ability of traditional antibiotics to treat drug resistant bacteria calls for new therapeutic alter natives.A class of unique sul-fanilamide aminophosphonates as new potential agents against microbes was synthesized by one-pot three-component reaction. | Juan Wang Mohammad Fawad Ansari Jian-Mei Lin Cheng-He Zhou | 2021 | Chinese Journal of Chemistry2021，39，8： | 1 |
| 17 | Bactericidal efficacy of photody- namic therapy against Enterococcus faecalis in infected root canals: a systematic literature review 显示文摘 | Shoaib HS Kamran HA Fawad J | 2013 | Photodiagnosis and Photodynamic Therapy2013，10，4： | 1 |
| 18 | Classification of Citrus Plant Diseases Using Deep Transfer Learning显示文摘In recent years,the field of deep learning has played an important role towards automatic detection and classification of diseases in vegetables and fruits.This in turn has helped in improving the quality and production of vegetables and fruits.Citrus fruits arewell known for their taste and nutritional values.They are one of the natural and well known sources of vitamin C and planted worldwide.There are several diseases which severely affect the quality and yield of citrus fruits.In this paper,a new deep learning based technique is proposed for citrus disease classification.Two different pre-trained deep learning models have been used in this work.To increase the size of the citrus dataset used in this paper,image augmentation techniques are used.Moreover,to improve the visual quality of images,hybrid contrast stretching has been adopted.In addition,transfer learning is used to retrain the pre-trainedmodels and the feature set is enriched by using feature fusion.The fused feature set is optimized using a meta-heuristic algorithm,the Whale Optimization Algorithm(WOA).The selected features are used for the classification of six different diseases of citrus plants.The proposed technique attains a classification accuracy of 95.7%with superior results when compared with recent techniques. | Muhammad Zia Ur Rehman Fawad Ahmed Muhammad Attique Khan Usman Tariq Sajjad Shaukat Jamal Jawad Ahmad Iqtadar Hussain | 2022 | Computers, Materials & Continua2022，，1： | 1 |
| 19 | Evaluation of EURIPIDES pile load tests response from CPT data显示文摘 | Fawad S Niazi Paul W Mayne | 2010 | International Journal of G eoengineering Case Histories2010，1，4： | 1 |
| 20 | Laskenl Unbiased Whole-Genome Amplification Directly From Clinical Samples显示文摘 | Seiyu Hosono A Fawad Faruqi Frank B Dean | 2003 | Genome research2003，13，5： | 1 |
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