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| 1 | Resective surgery for liver tumor: a multivariate analysis of causes and risk factors linked to postoperative complications显示文摘BACKGROUND: In spite of accurate selection of patients eligible for resection, and although advances in surgical techniques and perioperative management have greatly contributed to reducing the rate of perioperative deaths, stress must be placed on reducing the postoperative complication rates reported to be still as high as 50%. This study was designed to analyze the causes and foreseeable risk factors linked to postoperative morbidity on the grounds of data derived from a single-center surgical population. METHODS: From September 1989 to March 2005, 287 consecutive patients, affected either with HCC or liver metastasis, had liver resection at our department. Among the HCC series we recorded 98 patients (73.2%) in Child- Pugh class A, 32 (23.8%) in class B and 4 in class C (3%). In 104 colorectal metastases, 71% were due to colon cancer, 25% rectal, 3% sigmoid, and 1% anorectal. In 49 non-colorectal metastases, 22.4% were derived from breast cancer, 63.2% gastrointestinal tumors (excluding colon) and 14.4% other cancers. We performed 80 wedge resections, 77 bisegmentectomies and/or left lobectomies, 74 segmentectomies, 22 major hepatectomies, 20 left hepatectomies, and 14 trisegmentectomies. RESULTS: The in-hospital mortality rate in this series was 4.5%, and the morbidity rate was 47.7%, because of pleural effusion (30%), hepatic abscess (25%), hepatic insufficiency (19%), ascites (10%), hemoperitoneum (10%), or biliary fistula (6%). The variables associated with the technical aspects of the surgical procedure thatwere responsible for the complications were: a Pringle maneuver length more than 20 minutes (P=0.001); the type of liver resection procedure, including major hepatectomy (P=0.02), left hepatectomy (P=0.04), trisegmentectomy (P=0.04), bisegmentectomy and/or left lobectomy (P=0,04); and a blood transfusion of more than 600 ml (P=0.04). CONCLUSION: The evaluation of causes and foreseeable risk factors linked to postoperative morbidity during the planning of surgical treatment should play the same role as other factors weighed in the selection of patients eligible for liver resection. | Enrico Benzoni Dario Lorenzin Umberto Baccarani Gian Luigi Adani Alessandro Favero Alessandro Cojutti Fabrizio Bresadola Alessandro Uzzau | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 17 |
| 2 | Obesity in kidney disease:A heavyweight opponen显示文摘Obesity is an important worldwide challenge that must be faced in most developed and developing countries because of unhealthy nutritional habits.The consequences of obesity and being overweight are observed in different organs,but the kidney is one of the most affected.Excess adipose tissue causes hemodynamic alterations in the kidney that can result in renal disease.However,obesity is also commonly associated with other comorbidities such as chronic inflammation,hypertension and diabetes.This association of several aggravating factors is still a matter of concern in clinical and basic research because the pathophysiologic mechanisms surrounding chronic kidney disease development in obese patients remain unclear.This review will discuss the consequences of obesity in the context of renal injury. | Raphael Jose Ferreira Felizardo Marina Burgos da Silva Cristhiane Favero Aguiar Niels Olsen Saraiva Camara | 2014 | World Journal of Nephrology2014，3，3： | 7 |
| 3 | Metabolic surgery and intestinal gene expression:Digestive tract and diabetes evolution considerations显示文摘AIM: To investigate the effects of bariatric surgery on metabolic parameters, incretin hormone secretion, and duodenal and ileal mucosal gene expression.METHODS: Nine patients with type 2 diabetes mellitus(T2DM), chronic serum hyperglycemia for more than2 years, and a body mass index(BMI) of 30-35 kg/m2 underwent metabolic surgery sleeve gastrectomy with transit bipartition between May 2011 and December2011. Blood samples were collected pre and 3, 6 and12 mo postsurgery. Duodenal and ileal mucosa samples were collected pre- and 3 mo postsurgery. Pre- and postoperative blood samples were collected in the fasting state before ingestion of a standard meal(520kcal) and again 30, 60, 90, and 120 min after the mealto determine hemoglobin A1c(HbA1c) levels and the lipid profile, which consisted of triglyceride and total cholesterol levels. Intestinal gene expression of p53 and transforming growth factor(TGF)-β was analyzed using quantitative reverse-transcription PCR. Gastric inhibitory polypeptide(GIP) and glucagon-like peptide-1(GLP-1)were quantified using the enzyme-linked immunoassay method and analyzed pre- and postoperatively.Student's t test or repeated measurements analysis of variance with Bonferroni corrections were performed as appropriate.RESULTS: BMI values decreased by 15.7% within the initial 3 mo after surgery(31.29 ± 0.73 vs 26.398± 0.68, P < 0.05) and then stabilized at 22% at 6mo postoperative, resulting in similar values 12 mo postoperatively(20-25 kg/m2). All of the patients experienced improved T2 DM, with 7 patients(78%)achieving complete remission(HbA1c < 6.5%), and 2patients(22%) achieving improved diabetes(HbA1c< 7.0% with or without the use of oral hypoglycemic agents). At 3 mo postoperatively, fasting plasma glucose had also decreased(59%)(269.55 ±18.24 mg/dL vs 100.77 ± 3.13 mg/dL, P < 0.05)with no further significant changes at 6 or 12 mo postoperatively. In the first month postoperatively,there was a complete withdrawal of hypoglycemic medications in all patients, who were taking at least2 hypoglycemic drugs preoperatively. GLP-1 levels significantly increased after surgery(149.96 ± 31.25 vs220.23 ± 27.55)(P < 0.05), while GIP levels decreased but not significantly. p53 gene expression significantly increased in the duodenal mucosa(P < 0.05, 2.06 fold)whereas the tumor growth factor-β gene expression significantly increased(P < 0.05, 2.52 fold) in the ileal mucosa after surgery.CONCLUSION: Metabolic surgery ameliorated diabetes in all of the patients, accompanied by increased antiproliferative intestinal gene expression in non-excluded segments of the intestine. | Marcos Ricardo da Silva Rodrigues Marco Aurelio Santo Giovani Marino Favero Elaine Cristina Vieira Roberto Ferreira Artoni Viviane Nogaroto Egberto Gaspar de Moura Patricia Lisboa Fabio Quirillo Milleo | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 4 | Micro-Structured Fiber Interferometer as Sensitive Temperature Sensor显示文摘 | F. C. FAVERO M. BECKER, R. SPITTEL M. ROTHHARDT J. KOBELKE H. BARTELT | 2013 | Photonic Sensors2013，3，3： | 2 |
| 5 | Stress proteins in ex- perimental nephrotoxicity: A ten year experience 显示文摘 | Stacchiotti A Bonomini F Favero G | 2010 | Ital J Anat Embryol2010，115，12： | 1 |
| 6 | Ridge preservation at implants installed immediately after molar extraction. An experimental study in the dog显示文摘 | Giacomo Favero Niklaus P. Lang Enzo Santis Brismayda Garcia Gonzalez Michael T. Schweikert Daniele Botticelli | 2012 | Clin Oral Implants Res2012，，3： | 1 |
| 7 | Surgical treat- ment of congenital pulmonary arteriovenous fistula in children 显示文摘 | Fraga JC Favero E Contelli F | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 8 | Ecto 5-nucleotidase and adenosine deaminase activities of lymphoid cells显示文摘 | Domard J Bonnafous JC Favero J | 1982 | Biochem Med1982，28，： | 1 |
| 9 | Lactate inhibits Caz+ -activated Caz+ -channel activity from skeletal muscle sarcoplasmic reticulum 显示文摘 | Favero T G Zable A C Colter D | 1997 | Journal of Applied Physiology1997，82，2： | 1 |
| 10 | Anionic surfmers in miniemulsion polymerisation显示文摘 | Guyot A Graillat C Favero C | 2003 | Comptes Rendus Chim2003，6，1112： | 1 |
| 11 | Invasive cervical cancerduring pregnancy : laparoscopic nodal evaluation before oncologictreatment delay 显示文摘 | Favero G Chiantera V Oleszczuk A | 2010 | Gynecol Oncol2010，118，2： | 1 |
| 12 | Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction 显示文摘 | Rodella LF Favero G Boninsegna R | 2011 | Microsc Res Tech2011，74，8： | 1 |
| 13 | Explaining co-movements between stock markets: The case of US and Germany显示文摘 | Bonfiglioli A Favero C A | 2005 | Journal of International Money and Finance2005，24，： | 1 |
| 14 | A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: chondro-protective effect in a rabbit model of early OA 显示文摘 | Mero A Campisi M Favero M | 2014 | J Control Release2014，10，187： | 1 |
| 15 | Systematic coronary stenting after failed thrombolysis in high-risk patients with acute myocardial infarction:procedural results and long-term follow-up显示文摘 | Favero L Martini M | 2003 | Coron Artery Dis2003，14，5： | 1 |
| 16 | Orthodontic anchorage with specific fixtures:related study analysis 显示文摘 | Favero L Brollo P Bressan E | 2002 | Am J Orthod Dentofacial Orthop2002，122，1： | 1 |
| 17 | A new Doppler signal enhancing agent for flow assessment in breast lesions显示文摘 | Madjar H Prompeler HJ Del Favero C | 2000 | Eur J Ultrasound2000，12，2： | 1 |
| 18 | Chronic pain se-verity and depression/somatization levels in TMD patients显示文摘 | Manfredini D’Borella L Favero L | 2010 | Int J Prosthodont2010，23，6： | 1 |
| 19 | Term Structure Forecasting: No - Arbitrage Restrictions Versus Large Information Set 显示文摘 | Carlo A Favero Linlin Niu Luca Sala | 2012 | Journal of Forecasting2012，，2： | 1 |
| 20 | Effects of an acute bout of static stretching on 40 m sprint performance: influence of baseline flexibility显示文摘 | FAVERO J P MIDGLEY A W BENTLEY D J | 2009 | Research in Sports Medicine2009，17，1： | 1 |
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