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| 1 | 延胡索酸水合酶缺陷型肾细胞癌32例临床病理和分子分析显示文摘延胡索酸水合酶缺陷型肾细胞癌属于罕见的、新近发现的与遗传性平滑肌瘤病和肾细胞癌综合征相关的肿瘤实体。延胡索酸水合酶缺陷型肾细胞癌可表现出多种临床和病理学表现,但通常表现为局部进展和转移性疾病,预后较差。作者通过延胡索酸水合酶免疫组化和(或)延胡索酸水合酶突变分析确定32例延胡索酸水合酶缺陷型肾细胞癌,并对其临床和病理特征进行回顾性分析。 | Lau H D Chan E Fan A C 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，3： | 19 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation显示文摘 | Wanqiang Sheng Fan Yang Yi Zhou Henry Yang Pey Yng Low David Michael Kemeny Patrick Tan Akira Moh Mark H Kaplan Yongliang Zhang Xin-Yuan Fu | 2014 | Cell Research2014，24，12： | 7 |
| 4 | Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrah. ydropyrindine and astrocytic modulation显示文摘 | Fan, Y. | 2008 | 南京医科大学学报(自然科学版)2008，28，12： | 7 |
| 5 | Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells.显示文摘 | Fan GH Zhou HY Yang H Chert SD | 2006 | 中国生物学文摘2006，20，9： | 6 |
| 6 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 7 | Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks显示文摘Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its therapeutic use has been limited due to its carcinogenic potential. Plant-derived phytoestrogens are attractive alternatives, but reports on their angiogenic activities often lack in-depth analysis and sometimes are controversial. Herein, we report a data-mining study with the existing literature, using IPA system to classify and characterize phytoestrogens based on their angiogenic properties and pharmacological consequences. We found that pro-angiogenic phytoestrogens functioned predominantly as cardiovascular protectors whereas anti-angiogenic phytoestrogens played a role in cancer prevention and therapy. This bidirectional regulation were shown to be target-selective and, for the most part, estrogen-receptor-dependent. The transactivation properties of ERα and ERβ by phytoestrogens were examined in the context of angiogenesis-related gene transcription. ERα and ERβ were shown to signal in opposite ways when complexed with the phytoestrogen for bidirectional regulation of angiogenesis. With ERα, phytoestrogen activated or inhibited transcription of some angiogenesis-related genes, resulting in the promotion of angiogenesis, whereas, with ERβ, phytoestrogen regulated transcription of angiogenesis-related genes, resulting in inhibition of angiogenesis. Therefore, the selectivity of phytoestrogen to ERα and ERβ may be critical in the balance of pro- or anti-angiogenesis process. | LIU Hai-Xin WANG Yu LU Qing YANG Ming-Zhu FAN Guan-Wei KARAS Richard H GAO Xiu-Mei ZHU Yan | 2016 | Chinese Journal of Natural Medicines2016，14，4： | 4 |
| 8 | Keap1-Nrf2-ARE和p53/p21信号通路在对乙酰氨基酚引起肝损伤后肝再生中的作用显示文摘对乙酰氨基酚(acetaminophen,APAP)过量使用是引起肝损伤的主要原因。代偿性肝再生是药物性肝损伤的关键因素。但是APAP引起的肝损伤后肝再生的分子机制尚不清楚。本文旨在讨论Keapl—Nrf2-ARE和p53/p21信号通路在APAP引起肝损伤后肝再生中的作用。研究人员通过给予小鼠400mg/kg的APAP体内注射后发现,小鼠在12h内表现出巨大的肝毒性,而肝脏功能的恢复却要在24h之后。 | Fan X Chen P Tan H 牛强 | 2014 | 中华损伤与修复杂志(电子版)2014，9，5： | 2 |
| 9 | Generation of nematic liquid crystal alignment with polyimides exposed to linearly polarized light of long wavelength显示文摘 | Y H Wang Y Z Chen Z W Lin H. D. Sun J. S. Fan | | 0，，： | 2 |
| 10 | Blind channel identification:subspace tracking method without rank estimation显示文摘 | X Li H Fan | 2001 | IEEE Trans on Sig Proc2001，49，10： | 1 |
| 11 | Theoretical study of BexZn1-xO alloys显示文摘 | Ding S F Fan G H Li S T | 2007 | Physiea B2007，394，： | 1 |
| 12 | Completeness relation of the SU(3) charged and hypercharged coherent state 显示文摘 | Fan H Y Zou H Wei H | 1998 | Commun Theor Phys1998，29，： | 1 |
| 13 | Characterization of Pyrazines in someChinese liquors and their approximate concentrations 显示文摘 | FAN W L XU Y ZHANG Y H | 2007 | J Agric Food Chem2007，55，24： | 1 |
| 14 | Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells显示文摘 | Lei J Wendt C H Fan D | 2007 | Am J Physiol Lung Cell Mol Physiol2007，292，1： | 1 |
| 15 | An Empirical Analysis of Energy Efficiency in China's Iron and Steel Sector 显示文摘 | Wei Y M Liao H Fan Y | 2007 | Energy Policy2007，32，12： | 1 |
| 16 | Structural evolution of mechanically alloyed nanocrystalline Fe-28Al powders显示文摘 | FAN R H SUN J T GONG H Y SUN K N WANG W M | 2005 | Powder Technol2005，149，： | 1 |
| 17 | Disentangling the Incentive and Entrenchment Effects of Large Shareholders显示文摘 | Claessens s Djankov S Joseph P H Fan Larry H P Lang | 2002 | Journal of Finance2002，57，： | 1 |
| 18 | Wavelet-based linear system modeling and adaptive filtering显示文摘 | Doroslovacki M Fan H | 1996 | IEEE Trans on Signal Processing1996，44，5： | 1 |
| 19 | Cyr61 is up-regulated in prostate cancer and associated with the p53 gene status显示文摘 | Lv H Fan E Sun S | 2009 | J Cell Biochem2009，106，4： | 1 |
| 20 | TRPC6 Up-regulation in Ang Ⅱ-induced podocyte apoptosis might result from ERK activation and NF-kB translocation显示文摘 | Zhang H Ding J Fan Q | 2009 | Exp Biol Med2009，234，9： | 1 |
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