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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Review of recent research into cellulosic whiskers,their properties and their application in nanocomposite field显示文摘 | Azizi S Fannie A Alain D | | 0，，02： | 1 |
| 3 | Biodegradable nanoparticles-from sustained release formulations to improved site specific drug delivery显示文摘 | Jean-CL Eric A Fanny D J | 1996 | J Controlled Release1996，39，： | 1 |
| 4 | Fe/N/C non-precious catalysts for PEM fuel cells: Influence of the structural parameters of pristine commercial carbon blacks on their activity for oxygen reduction显示文摘 | Fanny Charreteur Frédéric Jaouen Stéphane Ruggeri Jean-Pol Dodelet | 2007 | Electrochimica Acta2007，，6： | 1 |
| 5 | R eduction o fpostoperative ile u s by early enteral n u tritio n in patientsundergoing m ajor re cta l surgery: prospective, random ized,co n tro lle d tria l 显示文摘 | Petra G Fanny F Luyer M isha D | 2014 | Ann Surg2014，259，4： | 1 |
| 6 | Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone显示文摘 | CARINE D FANNY H JEAN-CHARLES L | 2007 | Regulatory Toxicology and Pharmacology2007，49，： | 1 |
| 7 | Charge-based characterization of nanometric cationic bifunctional maghemite/silica core/shell particles by capillary zone electrophoresis显示文摘 | Fanny d' Orlye' Anne Varenne Thomas Georgelin | 2009 | Electrophoresis2009，30，： | 1 |
| 8 | Inversion of MLP neural networks for direct solution of inverse problems显示文摘 | Cherubini D Fanni A | 2005 | IEEE Transactions on Magnetics2005，41，5： | 1 |
| 9 | Morphogenesis and Molecular Mechanisms Involved in Human Kidney Development显示文摘 | Faa G Gerosa C Fanni D | 2012 | J CellPhysiol2012，227，3： | 1 |
| 10 | c-texture versus a-texture low pressure metalorganic chemical vapor deposition ZnO films: Lower resistivity despite smaller grain size 显示文摘 | Fanni L Aebersold B A Alexander D T L | 2014 | Thin Solid Films2014，565，1： | 1 |
| 11 | Tailoring the sur- face morphology of zinc oxide films for high-performance micromorph solar cells 显示文摘 | Ding L Fanni L Messerschmidt D | 2014 | Solar Energy Materials and So- lar Cells2014，128，1： | 1 |
| 12 | Thymosin beta 10 expression in developing human salivary glands显示文摘 | Fanni D Gerosa C Nemolato S | 2011 | Early Hum Dev2011，87，12： | 1 |
| 13 | Inver- sion of MLP neural networks for direct solution of inverse problems 显示文摘 | CHERUBINI D FANNI A MONTISCI A | 2005 | Magnetics IEEE Transactions on2005，41，5： | 1 |
| 14 | Amino functionalized thin films prepared from Gabriel synthesis applied on electrografted diazonium salts 显示文摘 | Fanny H Nabila D Serge P | 2012 | Journal of Electroanalytical Chemistry2012，677，： | 1 |
| 15 | Reoxygenation of asphyxiated newborn piglets: administration of 100% oxygen causes signifi- cantly higher apoptosis in cortical neurons, as compared to 21% 显示文摘 | Faa G Fanas V Fanni D | 2014 | Biomed Res Iut2014，2014，47： | 1 |
| 16 | A (H1N1) pandemic influenza and its prevention by vaccination: paediatricians' opinions before and after the beginning of the vaccination campaign显示文摘 | Dube E Fannie D Vladimir G | 2011 | BMC Public Health2011，11，： | 1 |
| 17 | Review of recent research into cellulosic whiskers,their properties and their application in nanocomposite field显示文摘 | Azizi S Fannie A Alain D | 2005 | Biomacromolecules2005，6，2： | 1 |
| 18 | The engagement of stakeholders in the marine spatial planning process 显示文摘 | ROBERT P FANNY D | | Marine Policy0，32，5： | 1 |
| 19 | Diffusion control formation of porestructures in ternary polymer system显示文摘 | Cohen C Fanny G B Etger S D | 1979 | J Polym Sci1979，17，： | 1 |
| 20 | MUC1 in mesenchy-mal-to-epithelial transition during human nephrogenesis:changing the fate of renal progenitor/stem cells?显示文摘 | Fanni D Fanos V Monga G | 2011 | J Ma-tern Fetal Neonatal Med2011，242，： | 1 |
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