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| 1 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 2 | Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome显示文摘Immunoproteasome activation in immune cells is involved in the modulation of immune responses.Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases,but it remains unclear whether proteasome inhibition is an effective approach for suppressing autoimmune development in Sjögren’s syndrome(SS).Our previous work has demonstrated a critical role for Th17 cells in the development of experimental SS(ESS)in mice.In this study,we detected high levels of low-molecular-weight protein 7(LMP7),a key subunit of the immunoproteasome,in Th17 cells from ESS mice.Moreover,treatment with bortezomib(BTZ),a proteasome inhibitor,markedly suppressed Th17 differentiation in both murine and human naive T cells in culture.Furthermore,ESS mice treated with BTZ displayed significantly higher saliva flow rates and a reduction in tissue destruction in the salivary glands compared with vehicle-treated ESS mice.Notably,BTZ-treated ESS mice showed markedly decreased Th17 cells,germinal center B cells and plasma cells in the peripheral lymphoid organs.In addition,adoptively transferred wild type naive CD4+T cells rapidly differentiated into Th17 cells and induced salivary dysfunction in IL-17-deficient mice immunized for ESS induction.However,BTZ treatment profoundly suppressed the donor T-cell-derived Th17 response and ameliorated the reduction in salivary secretion in IL-17-deficient recipient mice.Taken together,our findings demonstrate that proteasome inhibition can effectively ameliorate ESS by suppressing the Th17 response,which may contribute to the development of a novel therapeutic strategy for the treatment of SS. | Fan Xiao Xiang Lin Jie Tian Xiaohui Wang Qian Chen Ke Rui Jie Ma Shengjun Wang Qingwen Wang Xiaoqi Wang Dongzhou Liu Lingyun Sun Liwei Lu | 2017 | Cellular & Molecular Immunology2017，14，11： | 6 |
| 3 | Existence and uniqueness result for multidimensional BSDEs with generators of Osgood type显示文摘 | Shengjun FAN Long JIANG Matt DAVISON | 2013 | Frontiers of Mathematics in China2013，8，4： | 4 |
| 4 | Super Na^(+)Half/Full Batteries and Ultrafast Na+Diffusion Kinetics of Cobalt-Nickel Selenide from Assembling Co_(0.5)Ni_(0.5)Se_(2)@NC Nanosheets into Cross-Stacked Architecture显示文摘Explorati on of adva need an ode materials for sodium-i on batteries(SIBs)is still a big challe nge due to the large radius of sodium.In this work,the hierarchical architectures assembled from N-doped carbon-coated Co_(0.5)Ni_(0.5)Se_(2)(Co_(0.5)Ni_(0.5)Se_(2)@NC)nanoparticles encapsulated into cross-stacked nano sheets have been successfully prepared from the cobalt-nickel bin ary-metal organic frameworks(CoNi-MOF)by two steps of the solid-state sele nizati on and carb on coating processes.Imports ntly,the resulta nt hierarchical Co0.5Nio:5Se2@NC architecture can achieve a satisfactory electrochemical performance,maintaining a high-rate capacity of 330 mA-h-g^(-1)1 at 3 A·g^(-1) and a stable cyclability of 100 cycles without obvious capacity decay at 0.2 A·g^(-1).The design of distinct superstructure can not only be applied to other electrode materials but also boost the forward development of energy storage systems. | Zhiyong Li Zilin Peng Rui Sun Zhaoxia Qin Xinlong Liu Caihong Wang Haosen Fan Shengjun Lu | 2021 | Chinese Journal of Chemistry2021，39，9： | 3 |
| 5 | Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis显示文摘 | Shengjun Wu Bin Feng Kai Li Xia Zhu Shuhui Liang Xufeng Liu Shuang Han Biaoluo Wang Kaichun Wu Danmin Miao Jie Liang Daiming Fan | 2012 | The American Journal of Medicine2012，，6： | 2 |
| 6 | Ecological selection of bacterial taxa with larger genome sizes in response to polycyclic aromatic hydrocarbons stress显示文摘Polycyclic aromatic hydrocarbons(PAHs)are ubiquitous priority pollutants that cause great damage to the natural environment and health.Average genome size in a community is critical for shedding light on microbiome's functional response to pollution stress within an environment.Here,microcosms under different concentrations were performed to evaluate the selection of PAHs stress on the average genome size in a community.We found the distinct communities of significantly larger genome size with the increase of PAHs concentration gradients in soils,and consistent trends were discovered in soils at different latitudes.The abundance of Proteobacteria and Deinococcus-Thermus with relatively larger genomes increased along with PAHs stress and well adapted to polluted environments.In contrast,the abundance of Patescibacteria with a highly streamlined and smaller genome decreased,implying complex interactions between environmental selection and functional fitness resulted in bacteria with larger genomes becoming more abundant.Moreover,we confirmed the increased capacity for horizontal transfer of degrading genes between communities by showing an increased connection number per node positively related to the nid A gene along the concentration gradients in the co-occurrence network.Our findings suggest PAHs tend to select bacterial taxa with larger genome sizes,with significant consequences for community stability and potential biodegradation strategies. | Yuzhu Dong Shanghua Wu Haonan Fan Xianglong Li Yijing Li Shengjun Xu Zhihui Bai Xuliang Zhuang | 2022 | Journal of Environmental Sciences2022，34，2： | 2 |
| 7 | One-dimensional BSDEs with finite and infinite time horizons显示文摘 | ShengJun Fan Long Jiang DeJian Tian | 2010 | Stochastic Processes and their Applications2010，，3： | 1 |
| 8 | Finite and infinite time interval BSDEs with non-Lipschitz coefficients显示文摘 | ShengJun Fan Long Jiang | 2010 | Statistics and Probability Letters2010，，11： | 1 |
| 9 | One-dimensional BSDEs with finite and infinite time horizons显示文摘 | Fan Shengjun Jiang Long Tian Dejian | 2011 | Stoch Process Appl2011，121，3： | 1 |
| 10 | Lp 1) solutions for one-dimensional BSDEs with linear-growth gener-ators显示文摘 | FAN Shengjun JIANG Long | 2012 | Journal of Applied Mathematics and Computing2012，38，12： | 1 |
| 11 | Electrochemical and Pseudocapacitive Analysis of Rod-Like MoO_(2)@MoSe_(2)@NC Heterostructures for High-Performance Lithium Ion Batteries显示文摘A micro-scale rod-like heterostructure derived from molybdenum-based metal organic framework(Mo-MOF)has been successfully prepared via subsequent annealing treatment,which assembled from N-doped carbon encapsulated MoSe_(2) nanosheets grown on the surface of MoO_(2) microrod(named as MoO_(2)@MoSe_(2)@NC).For this novel heterostructure,the MoO_(2) nanoparticles assembled into rod core not only serve as supporting substrate for facilitating the fast kinetics of Li+cations inside the electrode but also protect the MoSe_(2) structure from restacking in the charge/discharge process.Moreover,the outer-layered MoSe2 nanosheets enable the fast lithium ion movement owing to its large interlayer spacing.Moreover,this unique rod-like core-shell structure composite could further effectively alleviate the structural strains caused by large volume expansion during charge/discharge process,thus leading to stable electrochemical performance when evaluated as anode material for lithium ion batteries.Electrochemical testing exhibits that the MoO_(2)@MoSe_(2)@NC heterostructure presents highly reversible capacity of 468 mAh g^(-1)at 0.5 A g^(-1)and superior rate capability(318 mAh g^(-1)even at 5.0 A g^(-1)),which is attributed to the synergistic effect of N-doped carbon encapsulated MoSe2 nanosheets and MoO_(2) nanoparticles. | Zhaoxia Qin Xinlong Liu Zhiyin Huang Rui Sun Zhiyong Li Haosen Fan Shengjun Lu | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，3： | 1 |
| 12 | Lp solutions of finite and infinite time interval BSDEs with non-Lipschitzcoefficients显示文摘 | FAN Shengjun’JIANG Long | 2012 | Stochastics An International Journal of Probability and Stochastic Processes2012，84，4： | 1 |
| 13 | One-dimensional BSDEs with finite and infinite time horizons显示文摘 | FAN Shengjun JIANG Long TIAN Dejian | 2011 | Stochastic Processes and Their Applications2011，121，3： | 1 |
| 14 | Jensen' s inequality for filtration consistent nonlinear expectation without domination condition显示文摘 | FAN Shengjun | 2008 | Journal of Mathematical Analysis and Applications2008，345，： | 1 |
| 15 | A Generalized Comparison Theorem for BSDEs and Its Applications 显示文摘 | Fan Shengjun Long Jiang | 2012 | Journal of Theoretical Probability2012，25，1： | 1 |
| 16 | Biomass and lipid production of marine microalgae using municipal wastewater and high concentration of CO2 显示文摘 | JIANG Liling LUO Shengjun FAN Xiaolei | 2011 | Applied Energy2011，88，10： | 1 |
| 17 | L^p(p > 1) Solutions of BSDEs with Generators Satisfying Some Non-uniform Conditions in t and ω显示文摘This paper is devoted to the L^p(p > 1) solutions of one-dimensional backward stochastic differential equations(BSDEs for short) with general time intervals and generators satisfying some non-uniform conditions in t and ω. An existence and uniqueness result,a comparison theorem and an existence result for the minimal solutions are respectively obtained, which considerably improve some known works. Some classical techniques used to deal with the existence and uniqueness of L^p(p > 1) solutions of BSDEs with Lipschitz or linear-growth generators are also developed in this paper. | Yajun LIU Depeng LI Shengjun FAN | 2020 | Chinese Annals of Mathematics,Series B2020，41，3： | 1 |
| 18 | Freestanding and Ultra‑flexible PAN/ZIF‑67 Hybrid Membrane with Controlled Porosity for High‑Performance and High‑Safety Lithium Batteries Separator显示文摘Herein,a flexible ZIF-67/PAN hybrid membrane was successfully prepared by the incorporation of ZIF-67 nanoparticles and PAN nanofibers through electrospinning method.The hybrid membrane presented tomatoes on sticks structures with one single PAN fiber stringing series of ZIF-67 nanoparticles.The morphology,electrolyte wettability,heat resistance,flexibility,and electrochemical properties of the electrospun ZIF-67/PAN membranes were discussed.Among the membranes prepared with different percentage of ZIF-67,the 30% ZIF-67/PAN membrane exhibited outstanding heat shrinkage resistance(remained intact at 200℃ for 1 h),excellent electrolyte uptake(556.39%),wide electrochemical window(~5.25 V)and high ionic conductivity(2.98 mS cm^(−1)).When used as lithium-ion batteries(LIBs)separators,the cells assembled by 30% ZIF-67/PAN membrane presented excellent rate capacity and high capacity retention of 86.9% after 300 cycles at 1C.More importantly,the cells assembled with ZIF-67/PAN membranes repeated bent for 1000 times also exhibited high rate performance and maintained capacity retention of 92% after 100 cycles at 1 C.The characterization and the electrochemical testing suggest the electrospinning prepared ZIF-67/PAN flexible membranes can be expected to be used as potential separator for advanced batteries with high safety and high performance. | Mao Guo Hangyi Zhu Pengfei Wan Feng Xu Caihong Wang Shengjun Lu Yufei Zhang Haosen Fan Jian Xu | 2022 | Advanced Fiber Materials2022，4，6： | 1 |
| 19 | Continuous dependence properties on solution of backward stochastic differential equation显示文摘 | FAN Shengjun WU Zhuwu ZHU Kaiyong | 2007 | Journal of Applied Mathematics and Computing2007，24，12： | 1 |
| 20 | One-dimensional BSDEs with finite and infinite time horizons显示文摘 | ShengJun Fan Long Jiang DeJian Tian | 2010 | Stochastic Processes and their Applications2010，，3： | 1 |
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