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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke显示文摘Our previous studies confirm that exogenous reduced nicotinamide adenine dinucleotide phosphate(NADPH)exerts a neuroprotective effect in animal models of ischemic stroke,and its primary mechanism is related to anti-oxidative stress and improved energy metabolism.However,it is unknown whether nicotinamide adenine dinucleotide(NADH)also plays a neuroprotective role and whether NADPH is superior to NADH against ischemic stroke?In this study we compared the efficacy of NADH,NADPH,and edaravone in ameliorating brain injury and metabolic stress in ischemic stroke.Transient middle cerebral artery occlusion/reperfusion(t-MCAO/R)mouse model and in vitro oxygen glucose deprivation/reoxygenation(OGD/R)model were established.The mice were intravenously administered the optimal dose of NADPH(7.5 mg/kg),NADH(22.5 mg/kg),or edaravone(3 mg/kg)immediately after reperfusion.We showed that the overall efficacy of NADPH in ameliorating ischemic injury was superior to NADH and edaravone.NADPH had a longer therapeutic time window(within 5 h)after reperfusion than NADH and edaravone(within 2 h)for ischemic stroke.In addition,NADPH and edaravone were better in alleviating the brain atrophy,while NADH and NADPH were better in increasing the long-term survival rate.NADPH showed stronger antioxidant effects than NADH and edaravone;but NADH was the best in terms of maintaining energy metabolism.Taken together,this study demonstrates that NADPH exerts better neuroprotective effects against ischemic stroke than NADH and edaravone. | Xin-xin Wang Fan Wang Guang-hui Mao Jun-chao Wu Mei Li Rong Han Jing She Rong Zhang Rui Sheng Zhong Chen Zheng-hong Qin | 2022 | Acta Pharmacologica Sinica2022，43，3： | 4 |
| 3 | CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice显示文摘Several factors have been implicated in obesity-related hypertension, but the genesis of the hypertension is largely unknown. In this study, we found a significantly upregulated expression of CPI-17(C-kinasepotentiated protein phosphatase 1 inhibitor of 17 kDa) and protein kinase C(PKC) isoforms in the vascular smooth muscles of high-fat diet(HFD)-fed obese mice. The obese wild-type mice showed a significant elevation of blood pressure and enhanced calcium-sensitized contraction of vascular smooth muscles. However, the obese CPI-17-deficient mice showed a normotensive blood pressure, and the calcium-sensitized contraction was consistently reduced. In addition, the mutant muscle displayed an abolished responsive force to a PKC activator and a 30%-50% reduction in both the initial peak force and sustained force in response to various G protein-coupled receptor(GPCR) agonists. Our observations showed that CPI-17-mediated calcium sensitization is mediated through a GPCR/PKC/CPI-17/MLCP/RLC signaling pathway. We therefore propose that the upregulation of CPI-17-mediated calcium-sensitized vasocontraction by obesity contributes to the development of obesity-related hypertension. | Jie Sun Tao Tao Wei Zhao Lisha Wei Fan She Pei Wang Yeqiong Li Yanyan Zheng Xin Chen Wei Wang Yanning Qiao Xue-Na Zhang Min-Sheng Zhu | 2019 | Journal of Genetics and Genomics2019，46，3： | 4 |
| 4 | Classification of carbonate gas condensate reservoirs using well test and production data analyses显示文摘碳酸盐水库模式在油和气体的生产表演起一个重要作用井,和它通常通过不能反映实际的井表演的静态的数据分析被分类。这份报纸在 Tarim 盆拿 Tazhong 号码 1 煤气的地,是的中国调查碳酸盐水库的分类的一个例子。分类方法主要特别把测试分析与生产分析相结合很好 Blasingame 类型曲线方法。为井测试分析和 Blasingame 方法基于类型曲线的特征,在类型曲线之间的关系和水库模式被建立。超过 20 口井被分析,水库与 7 个子类被分类进 3 个主要模式。而且,分类结果被井的动态表演分析在 Tazhong No.1 煤气的地里验证。根据分类结果,井刺激(即大量涌入一个单身者很好的水) 在三口不稳定油的井被执行,并且油恢复增加了多达 20% 。 | Li Yong Li Baozhu Hu Yongle Xia Jing Liu Zhaowei Deng Xingliang She Zhicheng Fan Kun | 2011 | Petroleum Science2011，8，1： | 3 |
| 5 | Construction of 2D/2D Z-scheme MnO_(2-x)/g-C_(3)N_(4) photocatalyst for efficient nitrogen fixation to ammonia显示文摘Reducing nitrogen to ammonia with solar energy has become a wide concern when it comes to photocatalysis research.It is considered to be one of the more promising alternate options for the conventional Haber-Bosch cycle.Herein,2D g-C_(3)N_(4)composites with modifying ultrathin sheet MnO_(2-x)were prepared and used as nitrogen fixation photocatalyst.With the assistance of the nature of MnO_(2-x),the generation rate of NH_(3)reached 225 mmol g^(-1)h^(-1),which is more than twice over the rate of pristine 2D g-C_(3)N_(4)(107 mmol g^(-1)h^(-1)).The presence of ultrathin sheet MnO_(2-x)shortens the gap of the carriers to the surface of photocatalyst.Thus the speed of electron transfer gets increased.Besides,the construction of Z-scheme heterojunction boosts the separation and migration of photogenerated carriers.As a result,the nitrogen reduction reaction(NRR)performance gets enhanced.The work may provide an example of promoting the NRR performance of non-metallic compound. | Limin Yu Zhao Mo Xianglin Zhu Jiujun Deng Fan Xu Yanhua Song Yuanbin She Huaming Li Hui Xu | 2021 | Green Energy & Environment2021，6，4： | 3 |
| 6 | Identifying the Risk of SARS-CoV-2 Infection and Environmental Monitoring in Airborne Infectious Isolation Rooms(AIIRs)显示文摘Healthcare workers(HCWs)are at high risk of occupational exposure to the new pandemic human coronavirus,SARSCoV-2,and are a source of nosocomial transmission in airborne infectious isolation rooms(AIIRs).Here,we performed comprehensive environmental contamination surveillance to evaluate the risk of viral transmission in AIIRs with 115 rooms in three buildings at the Shanghai Public Health Clinical Center,Shanghai,during the treatment of 334 patients infected with SARS-CoV-2.The results showed that the risk of airborne transmission of SARS-CoV-2 in AIIRs was low(1.62%,25/1544)due to the directional airflow and strong environmental hygiene procedures.However,we detected viral RNA on the surface of foot-operated openers and bathroom sinks in AIIRs(viral load:55.00–3154.50 copies/mL).This might be a source of contamination to connecting corridors and object surfaces through the footwear and gloves used by HCWs.The risk of infection was eliminated by the use of disposable footwear covers and the application of more effective environmental and personal hygiene measures.With the help of effective infection control procedures,none of 290 HCWs was infected when working in the AIIRs at this hospital.This study has provided information pertinent for infection control in AIIRs during the treatment of COVID-19 patients. | Zhi-Gang Song Yan-Mei Chen Fan Wu Lin Xu Bang-Fang Wang Lei Shi Xiao Chen Fa-Hui Dai Jia-Lei She Jian-Min Chen Edward CHolmes Tong-Yu Zhu Yong-Zhen Zhang | 2020 | Virologica Sinica2020，35，6： | 3 |
| 7 | Outcome of laparoscopic colectomy for cancer in elderly patients显示文摘 | Wong-Hoi She Jensen Tung-Chung Poon Joe King-Man Fan Oswens Siu-Hung Lo Wai-Lun Law | 2013 | Surgical Endoscopy2013，，1： | 2 |
| 8 | Interfacial Characteristic of as-Deformed SiCp-Reinforced Magnesium Matrix Composite显示文摘The(submicron+micron) Si Cp-reinforced magnesium matrix composite was fabricated by stir casting. After the application of forging and extrusion, the interface between Si Cp and Mg in the composite was investigated by transmission electron microscopy. Results show that the interfacial characterization was different at the interfaces of micron-Si Cp/Mg and submicron-Si Cp/Mg. While most interfaces between micron-Si Cp and Mg were clean, the precipitated Mg17Al12 phase as well as dispersedly distributed nano-Mg O particles was observed at some interfaces. Unlike the interface between micron-Si Cp and Mg, no interfacial reaction product was found at the interface between submicron-Si Cp and Mg in the present study. Besides, the specific orientation relationships were found at the interfaces between submicronSi Cp and Mg, which was thought to have developed during hot deformation process. At the fracture surface of the composite, the microcracks were found at the interface between micron-Si Cp and Mg, while the interfacial bonding between submicron-Si Cp and Mg was very well. | Kun Kun Deng Jian Chao Li Jian Feng Fan Xiao Jun Wang Kun Wu Bing She Xu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 2 |
| 9 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 10 | An infrared thermographic analysis of the sensitization acupoints of women with primary dysmenorrhea显示文摘OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD. | FAN Xisheng DU Xiaoyi PAN Lijia SONG Xiaodan LIU Jun ZHANG Juncha CHEN Hao GAO Yayu ZHANG Mingjian SHI Xuliang SHE Yanfen | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 11 | Identification of the hydrophobic glycoproteins of Caenorhabditis elegans显示文摘 | Fan X She Y M Bagshaw R D | 2005 | Glycobiology2005，15，10： | 1 |
| 12 | A novel compact electromagnetic-bandgap (EBG) structure and its applications for microwave circuits显示文摘 | Yang Li Fan Mingyan She Jingzhao | 2005 | IEEE Trans on MTT2005，53，1： | 1 |
| 13 | Association of HLA genes with diffusepanbronchiolitis in Chinese patients 显示文摘 | She J Sun Q Fan L | 2007 | Respir Physiol Neurobiol2007，157，23： | 1 |
| 14 | Outcome of laparoscopiccolectomy for cancer in elderly patients 显示文摘 | She W H Poon JT Fan JK | 2013 | Surg Endosc2013，27，1： | 1 |
| 15 | Outcome of laparoscopic colectomy for eaneer in elderly patients显示文摘 | She WH Poon JT Fan JK | 2013 | Surg Endose2013，27，3： | 1 |
| 16 | Outcome of laparoscopic colectomy for cancer in elderly patients 显示文摘 | She WH Poon JT Fan JK | 2013 | Surg Endosc2013，27，1： | 1 |
| 17 | Research on Urban Land Ecological Suitability Evaluation Based on Gravity-Resistance Model: A Case of Deyang City in China显示文摘 | FAN Chen-jing SHEN Shi-guang WANG Si-hui SHE Guang-hui WANG Xin-yi | 2011 | Procedia Engineering2011，，： | 1 |
| 18 | Outcome of laparoscopic colectomy for cancer in elderly patients 显示文摘 | She W H Pooh J T C Fan J K M | 2013 | Surgical endoscopy2013，27，1： | 1 |
| 19 | A novel compact electromagnetic-bandgap (EBG) structure and its applications for microwave circuits显示文摘 | L Yang M Fan F Chen J She Z Feng | 2005 | IEEE Trans on MTT2005，53，1： | 1 |
| 20 | A novel compact electromagnetic band gap (EBG) structure and its applications for microwave eircuits显示文摘 | Yang Li Fan Mingyan She Jingzhao | 2005 | IEEE Trans on Microwave Theory and Techniques2005，53，18： | 1 |
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