|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reversing cold tumors to hot: An immunoadjuvant-functionalized metalorganic framework for multimodal imaging-guided synergistic photoimmunotherapy显示文摘Immunotherapy assays using immunoadjuvants and tumor antigens could greatly increase the survival rates of patients with malignant tumors.As effective carriers,metal-organic frameworks(MOFs)have been widely utilized in cancer therapy due to their remarkable histocompatibility and low toxicity.Herein,we constructed a multimodal imaging-guided synergistic cancer photoimmunotherapy by employing a specific MOF(MIL101-NH2)as the core carrier;the MOF was dual-dressed with photoacoustic and fluorescent signal donors(indocyanine green,ICG)and immune adjuvants(cytosine-phosphate-guanine sequence,CpG)and named ICGCpG@MOF.This nanocarrier could passively target the tumor site through the EPR effect and achieve multimodal imaging(fluorescence,photoacoustic,photothermal and magnetic resonance imaging)of the tumor.Synergistic cancer photoimmunotherapy was achieved via simultaneous photodynamic and photothermal methods with 808 nm laser irradiation.ICG-CpG@MOF achieved the GSH-controlled release of immunoadjuvant into the tumor microenvironment.Furthermore,the released tumor-associated antigen along with CpG could induce the transformation of tumor cells from cold to hot by activating the immune system,which significantly enhanced tumor cytotoxicity and achieved high cure rates with minimal side-effects.This strategy utilizing multimodal imaging and synergistic cancer photoimmunotherapy provides a promising approach for the diagnosis and treatment of cancer. | Zhijin Fan Hongxing Liu Yaohua Xue Jingyan Lin Yu Fu Zhaohua Xia Dongming Pan Jian Zhang Kun Qiao Zhenzhen Zhang Yuhui Liao | 2021 | Bioactive Materials2021，6，2： | 4 |
| 2 | Design, Synthesis, and Biological Activity of Novel Aromatic Amide Derivatives Containing Sulfide and Sulfone Substructures显示文摘In recent years,the damage caused by soil nematodes has become increasingly serious;however,the varieties and structures of the nematicides available on the market are deficient.Fluopyram,a succinate dehydrogenase inhibitor(SDHI)fungicide developed by Bayer AG in Germany,has been widely used in the prevention and control of soil nematodes due to its high efficiency and novel mechanism of action.In this paper,two series of novel target compounds were designed and synthesized with nematicidal and fungicidal fluopyram as the molecular skeleton in order to introduce sulfide and sulfone substructures.The structures were identified and characterized by 1H nuclear magnetic resonance(NMR),13C NMR,and high-resolution mass spectrometer(HRMS).The bioassays revealed that most of the compounds showed excellent nematicidal activities at 200 lgmL-1 in comparison with fluopyram,while the nematode mortality rate dropped sharply at 100μg·mL-1,except for compounds I-11 and II-6.In terms of fungicidal activity,compound I-9 was discovered to have an excellent inhibitory rate,and a molecular docking simulation was performed that can provide important guidance for the design and exploration of efficient fungicidal lead compounds. | Xuewen Hua Nannan Liu Sha Zhou Leilei Zhana Hao Yin Guiqing Wang Zhijin Fan Yi Mac | 2020 | Engineering2020，6，5： | 4 |
| 3 | Synthesis of 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl Containing 1,2,3-Thiadiazole Derivatives via Ugi Reaction and Their Biological Activities显示文摘包含 4-methyl-1,2,3-thiadiazole 衍生物的一系列新奇 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy ) 苯基经由 Ugi 反应被设计并且综合。他们的结构被红外, 1H NMR, 13C NMR 和高分辨率的集体光谱学证实。初步的生物鉴定结果显示一些标题混合物在 50 g/mL 举办了好杀真菌剂活动;大多数混合物在 500 g/mL 和 100 g/mL 对烟草马赛克病毒介绍了直接抑制活动,好 inactivation 和药品活动的某个度;一些混合物对 Plutella xylostella L 显示出好 larvicidal 活动。在对在 2 g/mL 的一种蚊虫 pipiens pallens 的 200 g/mL 和优秀 larvicidal 活动。 | Wang Shouxin Wang Huan Fan Zhijin Fu Yifeng Mi Na Zhang Jufang Zhang Zhengcai Belskaya Nataliya P. Bakulev Vasiliy A. | 2011 | Chinese Journal of Chemistry2011，29，2： | 4 |
| 4 | Design, Synthesis and Biological Evaluation of Isothiazole Based 1,2,4-Trizaole Derivatives显示文摘 | Lai Chen Qifan Wu Zhijin Fan Hongpeng Li Jiwei Li Wenhao Hu Xiumei Liu Nataliya P Belskaya Tatiana Glukhareva Bin Zhao | 2018 | Chinese Journal of Chemistry2018，36，8： | 2 |
| 5 | Simulation and experimental investigation of DC Ice-Melting process on an iced conductor显示文摘 | Jiang Xingliang Fan Songhai Zhang Zhijin | 2010 | IEEE Transactions on Power Delivery2010，25，2： | 1 |
| 6 | Simulation and experimental investigation of DC Ice-Melting process on an iced conductor显示文摘 | Jiang Xingliang Fan Songhai Zhang Zhijin | 2010 | IEEE Transactions on Power Delivery2010，25，02： | 1 |
| 7 | Simulation and experimental investigation of dc ice-- melting process on an iced conductor显示文摘 | Jiang Xingliang Fan Songhai Zhang Zhijin | 2010 | IEEE Trans on Power Delivery2010，25，2： | 1 |
| 8 | Bitriazolyl acyclonucleosides with antiviral activity against tobacco mosaic virus显示文摘 | Wei Li Yi Xia Zhijin Fan Fanqi Qu Qiongyou Wu Ling Peng | 2008 | Tetrahedron Letters2008，，17： | 1 |
| 9 | Design, Synthesis, and Evaluation of Fungicidal Activity of Novel Pyrazole-Containing Strobilurin Derivatives显示文摘In searching for novel fungicidal leads,a series of pyrazole-containing strobilurins were rationally designed,synthesized and charac-terized.Bioassay indicated that compound 1-7 displayed excellent fungicidal activity against a broad spectrum of plant pathogens such as Gibberella zeae,Rhizoctonia cereolis,Sclerotinia sclerotiorum,Phytophthora infestans,Physolosporo piricola and Pellicularia sosakii with EC_(50) of 0.16,0.02,0.72,0.07,0.77 and 0.65μg/mL,respectively,which were 3-10 times more potent than the positive control azoxystrobin against the corresponding pathogens.Moreover,like azoxystrobin and kresoxim methyl,1-7,displayed excellent protec-tive activity against P.sorghi.Molecular docking validated that 1-7 and azoxystrobin would share a similar binding mode with cytochrome bc_(1) complex.This study demonstrates that 1-7 is a promising fungicidal candidate for further development. | Zesheng Hao Weibo Wang Bin Yu Xin Qi You Lv Xiaoyu Liu Haoyin Chen Tatiana A.Kalinina Tatiana V.Glukhareva Zhijin Fan | 2021 | Chinese Journal of Chemistry2021，39，6： | 1 |
| 10 | Simulation and ex- perimental investigation of DC ice-melting process on an iced conductor显示文摘 | Jiang Xingliang Fan Songhai Zhang Zhijin | 2010 | IEEE Transactions on Power Delivery2010，25，2： | 1 |
| 11 | Simulation and experimental investigation of DC ice-melting process on an iced conductor 显示文摘 | Jiang Xingliang Fan Songhai Zhang Zhijin | 2010 | IEEE Transactions on Power Delivery2010，25，2： | 1 |
| 12 | Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus显示文摘 | Yi Xia Zhijin Fan Jianhua Yao Quan Liao Wei Li Fanqi Qu Ling Peng | 2006 | Bioorganic & Medicinal Chemistry Letters2006，，10： | 1 |
| 13 | Synthesis and biological activity evaluation of 1,2,3-thiadiazole deriva- tives as potential elicitors with highly systemic acquired resistance 显示文摘 | Fan Zhijin Shi Zugui Zhang Haike | 2009 | J Agric Food Chem2009，57，10： | 1 |
| 14 | Preparation of a bifunctional pyrazosulfuron-ethyl imprinted polymer with hydrophilic external layers by reversible addition–fragmentation chain transfer polymerization and its application in the sulfonylurea residue analysis显示文摘 | Meixian Yang Yingying Zhang Shen Lin Xinlin Yang Zhijin Fan Lixia Yang Xiangchao Dong | 2013 | Talanta2013，，： | 1 |
| 15 | Stability ofetofenprox in water emulsion induced by block copolymer andsurfactant显示文摘 | Zhang Xiaoguang Liu Jiexiang Fan Zhijin | 2013 | Colloids Surf A2013，422，： | 1 |
| 16 | Synthesis and Biological Activities of Novel 1,2,4-Triazole Derivatives Containing 1,2,3-Thiadiazole Ring显示文摘 | LI Yuedong MAO Wutao FAN Zhijin LI Juanjuan FANG Zhen JI Xiaotian ZONG Guangning LI Fengyun | 2014 | Chemical Research in Chinese Universities2014，30，3： | 0 |
| 17 | Novel dc flashover model for predicting flashover voltage of the iced insulators显示文摘This work first proposes a novel flashover model based on the deduced residual resis-tance of the ice layer. The most important finding of the field icing tests is that the double‐layer ice‐melting water film exists on the inner and outer surfaces of the ice layer. The conductivity of melting water on the inner and outer surface of the ice layer has been measured, and the corresponding surface conductivity has been calculated. According to the proposed flashover model, the ratio η of the resistance of the ice layer to that of the pollution layer gradually increases with the increase of the ratio k of the resistance of the outer surfaces to that of inner surfaces, and eventually approaches saturation. Further-more, the icing flashover criterion has been modified, and the voltage gradient of the inner surface is less than that of the outer surface. Test results show that the ice flashover voltage is lower than the pollution flashover voltage between 2.18-9.69% and 14.75- 20.32% under light ice and semi‐cylindrical ice, respectively. The simulation results based on the proposed model and the classic model are compared with the field test data. Results show that the proposed model could attain a high accuracy of dc flashover voltage and demonstrate the effectiveness of the proposed model. | Caijin Fan Xingliang Jiang Yanbin Xie Jianlin Hu Zhijin Zhang Qin Hu Maoqiang Bi | 2021 | High Voltage2021，6，1： | 0 |
| 18 | Rapid Screening for Insecticidal Compounds Using [^3H] EBOB Binding Assay显示文摘Binding assay is a convenient, simple, inexpensive, and rapid method that can be used for rapid screening insecticidal compounds. The present study examines 6 compounds for their inhibition of [3H] EBOB bound to housefly-head membranes, of which 3 compounds have potency for housefly-head membranes. | 巨修练 Fan Zhijin | 2004 | High Technology Letters2004，10，3： | 0 |
| 19 | Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria显示文摘Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious diseases.Herein,we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria-specific delivery of clinical antibiotic ciprofloxacin(CIP)and classic nanoantibiotic silver nanoparticles(AgNP).In our rational design,CIP was efficiently loaded in the self-assembly double-bundle DNA tetrahedron through intercalation with DNA duplex,and single-strand DNA-modified AgNP was embedded in the cavity of the DNA tetrahedron through hybridization.With the site-specific assembly of targeting aptamer in the well-defined DNA tetrahedron,the bacteria-specific dual-antibiotic delivery system exhibited excellent combined bactericidal properties.With enhanced antibiotic accumulation through breaking the out membrane of bacteria,the antibiotic delivery system effectively inhibited biofilm formation and promoted the healing of infected wounds in vivo.This DNAbased antibiotic delivery system provides a promising strategy for the treatment of antibiotic-resistant infections. | Tiantian Wu Yu Fu Shuang Guo Yanqiang Shi Yuxin Zhang Zhijin Fan Bin Yang Baoquan Ding Yuhui Liao | 2024 | Aggregate2024，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员