|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives显示文摘 | Lijuan Sun Lanjing Ma Yubo Ma Faming Zhang Changhai Zhao Yongzhan Nie | 2018 | Protein & Cell2018，9，5： | 29 |
| 3 | Experimental and numerical study on instability structure of the supersonic mixing layer(M_c = 0.5)显示文摘The parameters of instability wave of supersonic mixing layer(Mc=0.5,M1=3.5/M2=1.4) are measured by flow visualization and calculated by means of two-dimensional direct numerical simulaitons of the compressible Navier-Stokes equations.In both cases of the mixing layer with harmonic disturbance or not,the comparative results indicate that the wavelength of the two-dimensional wave is equal to the vortex spacing in the streamwise direction because the difference between them is less than 1%.However,the measured convective velocity of the large-scale structure deviates from the theoretical isentropic prediction about 10%.Here the measured value confirms that Mc,2 | YANG WuBing ZHUANG FengGan SHEN Qing GUAN FaMing WANG Qiang YI ShiHe ZHAO YuXin HE Lin TIAN LiFeng | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 2 |
| 4 | An Organic–Inorganic Hybrid Material Based on Benzo[ghi]perylenetri-imide and Cyclic Titanium-Oxo Cluster for Efficient Perovskite and Organic Solar Cells显示文摘Perovskite and organic solar cells usually require electron-transport interlayers to efficiently transport electrons from the photoactive layer to the metal electrode.In general,pure organic or inorganic materials are applied into the interlayers,but organic–inorganic hybrid materials have been rarely reported for this application.In this work,we report using the first titanium-oxo cluster-based organic–inorganic hybrid as the interlayer material by introducing largeπ-conjugated benzo[ghi]perylenetriimides as an organic part via a simple ligand-exchange reaction.This new hybrid material showed excellent solubility,well-aligned energy levels,and excellent electron mobilities,enabling its great potential application as an interlayer in solar cells such as perovskite and organic solar cells,providing high power conversion efficiencies of>20%and 16%,respectively.Therefore,we claim that our present work introduces a new class of cluster-based organic–inorganic hybrid interlayer materials that exhibit promising application in organic electronics. | Zhou Zhang Faming Han Jie Fang Chaowei Zhao Shuai Li Yonggang Wu Yuefeng Zhang Shengyong You Binghui Wu Weiwei Li | 2022 | CCS Chemistry2022，4，3： | 1 |
| 5 | Identifying the Zn-Co binary as a robust bifunctional electrocatalyst in oxygen reduction and evolution reactions via shifting the apexes of the volcano plot显示文摘The performance of an electrocatalyst is closely correlated with the binding strength of key oxygencontaining intermediates,i.e.,*OOH,*O and*OH,in the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).Facile strategies to achieve favorable binding strength of these oxygen-containing species are urgently demanded,yet it still remains great challenges.Herein,the Zn-Co bimetallic isolation,which serves as an ideal model,is studied systematically by the density functional theory(DFT).Reaction activity volcano plots are built from 48 models,among them the ZnCoN6-gra(I)configuration is confirmed to be the most stable,featured of the strongest interaction with the oxygen-containing species.Optimal △G*O(free energy change of an atomic oxygen containing intermediate)is facilitated,which effectively drifts the volcano peaks of ORR and OER closer to each other,enabling promising bifunctional catalyst.Moreover,the small overpotential in the simulation of protonation and oxidation by hydroxy groups rationalizes the durability of the catalyst in both acid and alkaline media. | Jing Wang Rui Xu Yuling Sun Qian Liu Meirong Xia Yan Li Faming Gao Yufeng Zhao John S.Tse | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 6 | Detection of Serum Gastric Cancer-Associated MG7-Ag from Gastric Cancer Patients Using a Sensitive and Convenient ELISA Method显示文摘 | Bin Jin Xin Wang Yan Jin Wensen Xia Bei Chen Lin Liu Zheng Chen Liu Hong Wenqi Du Kun Yan Honghong Wang Donghong Yuan Xiaoli Hui Li He Faming Zhang Yunping Zhao Kaichun Wu Daiming Fan | 2009 | Cancer Investigation2009，，2： | 1 |
| 7 | Effects of experimental nitrogen and/or phosphorus additions on soil nematode communities in a secondary tropical forest显示文摘 | Jie Zhao Faming Wang Jian Li Bi Zou Xiaoli Wang Zhian Li Shenglei Fu | 2014 | Soil Biology and Biochemistry2014，，： | 1 |
| 8 | Fecal microbiota transplantation is an effective rescue therapy for refractory inflammatory bowel disease显示文摘 | Bota Cui Pan Li Lijuan Xu Zhaoyuan Peng Youquan Zhao Huiquan Wang Zhi He Ting Zhang Guozhong Ji Kaichun Wu Daiming Fan Faming Zhang | 2015 | Inflammation and Cell Signaling2015，，： | 1 |
| 9 | Washed microbiota transplantation improves the fertility of patients with inflammatory bowel disease显示文摘To the Editor:Female patients with inflammatory bowel disease(IBD)have lower fertility rates and take longer time to conceive than the healthy population.How to improve the fertility in patients with IBD is a critical challenge. | Zhaoyang Zhao Xinghui Ji Ting Zhang Qianqian Li Cicilia Marcella Quan Wen Bota Cui Faming Zhang | 2022 | Chinese Medical Journal2022，，12： | 0 |
| 10 | The benefits of PCSK9 inhibitors in patients with acute coronary syndrome:a systematic review and meta-analysis显示文摘Background:Proprotein convertase subtilisin/kexin 9(PSCK9)inhibitors have been beneficial for many patients with hyperlipidemia.The objective of this study was to investigate the benefit of PSCK9 inhibitors in patients with acute coronary syndrome(ACS).Methods:We systematically searched PubMed,EMBASE,and Cochrane Clinical Trials(published before January 2023;no language restriction)to compare the treatment of patients with ACS using PCSK9 inhibitors and placebo.The primary end points were major adverse cardiovascular events,nonfatal myocardial infarction,cardiogenic death,stroke,hospitalization for recurrent ACS,and coronary revascularization.Fixed-or random-effects models were used to assess the aggregated data.Results:Of the 1686 identified studies,5 were eligible and included in our analysis(of a total of 38,005 participants,18,609 cases were placed in the PCSK9 inhibitor treatment group and 19,396 cases in the placebo group).Compared with the placebo group,PCSK9 inhibitors significantly reduced the major adverse cardiovascular events(odds ratio[OR]:0.83;95%confidence interval[CI]:0.77–0.88;P<0.00001)for patients following ACS.The incidence of nonfatal myocardial infarction(relative risk:0.80;95%CI:0.74–0.87;P<0.00001),cardiovascular death(OR:0.96;95%CI:0.83–1.10;P=0.56),stroke(OR:0.74;95%CI:0.63–0.88;P=0.0007),hospitalization for recurrent ACS(OR:0.57;95%CI:0.40–0.83;P=0.003),or coronary revascularization(OR:0.82;95%CI:0.76–0.88;P<0.00001)all demonstrated a significant decrease in the comparison between the 2 groups.Conclusion:This meta-analysis demonstrated that treatment with PCSK9 inhibitors in patients with ACS reduced the probability of multiple cardiovascular events and improved patient prognosis. | Guanzhao Zhang Shuting Chang Faming Zhao Xiangfeng Guan Zifan Nie Wenhao Liu Bo Li | 2024 | Emergency and Critical Care Medicine2024，4，1： | 0 |
| 11 | DNA-assisted rational design of BaF_2 linear and erythrocyteshaped nanocrystals显示文摘The synthesis of inorganic materials with special morphologies with the assistance of biological molecules is a potential development in the field of controllable growth and assembly of nanomaterials. In this paper, BaF_2 nanocrystals in patterns of well-defined linear and erythrocyte-shaped structure were synthesized with the assistance of Escherichia coli DNA. Morphology and the arrangement of BaF_2 particles on DNA were controllable by altering the reaction condition. Square nanoparticles arranged in linear chains were gained with the assistance of normal DNA; while, erythrocyte-shaped BaF_2 nanospheres were synthesized with the assistance of denatured DNA. Besides, the influences of solvent, reaction temperature, concentration of reactants and the heating time on the morphology of the BaF_2 particles were studied. | Xinmei Zhao Huanhuan You Faming Gao | 2018 | Chinese Journal of Chemical Engineering2018，26，7： | 0 |
| 12 | Application of Virtopsy in the Police Activities in China显示文摘This review summarizes the mode of application of virtual anatomy technology in the construction of a police system.Local public security organizations have explored the application modes of virtual anatomy construction,such as the multiparty co-construction mode,cooperation mode,and individual construction mode,and reviewed(l)the understanding of public security and application process of virtual anatomy;(2)the problems faced in the construction and application processes,such as those associated with support ofhuman resources,equipment supplies and financial expenditure,the limitations of the technology itself legal issues with application,shrinkage of the identification business,and appraiser-related problems;and(3)the prospect of application of virtopsy in public security systems. | Ligang Tang Zhe Liu Yan Xue Leilei Zhang Dongdong Zhao Lijiang Diao Yigang Zhang Faming Teng Peng Zhao | 2021 | Journal of Forensic Science and Medicine2021，7，1： | 0 |
| 13 | Reconstruction and Dynamics of the Human Intestinal Microbiome Observed In Situ显示文摘The human gut microbiome has primarily been studied through the use of fecal samples,a practice that has generated vital knowledge on the composition and functional capacities of gastrointestinal microbial communities.However,this reliance on fecal materials limits the investigation of microbial dynamics in other locations along the gastrointestinal tract(in situ),and the infrequent availability of fecal samples prevents analysis at finer temporal scales(e.g.,hours).In our study,we utilized colonic transendoscopic enteral tubing,a technology originally developed for fecal microbiota transplantation,to sample the ileocecal microbiome twice daily;metagenomic and metatranscriptomic analyses were then conducted on these samples.A total of 43 ileocecal and 28 urine and fecal samples were collected from five healthy volunteers.The ileocecal and fecal microbiomes,as profiled in the five volunteers,were found to be similar in metagenomic profiling,yet their active genes(metatranscriptome)were found to be highly distinct.Both microbiomes were perturbed after laxative exposure;over time,they exhibited reduced dissimilarity to their pre-treatment state,thereby demonstrating resilience as an innate property of the gut microbiome,although they did not fully recover within our observation time window.Sampling of the ileocecal microbiome during the day and at night revealed the existence of diurnal rhythms in a series of bacterial species and functional pathways,particularly those related to short-chain fatty acid production,such as Propionibacterium acnes and coenzyme A biosynthesis Ⅱ.Autocorrelation analysis and fluctuations decomposition further indicated the significant periodicity of the diurnal oscillations.Metabolomic profiling in the fecal and urine samples mirrored the perturbance and recovery in the gut microbiome,indicating the crucial contribution of the gut microbiome to many key metabolites involved in host health.This study provides novel insights into the human gut microbiome and its inner resilience and diurnal rhythms,as well as the potential consequences of these to the host. | Xiaolin Liu Min Dai Yue Ma Na Zhao Ziyu Wang Ying Yu Yakun Xu Huijie Zhang Liyuan Xiang He Tian Guanghou Shui Faming Zhang Jun Wang | 2022 | Engineering2022，8，8： | 0 |
| 14 | Effects of Chemical Reactions in the Hypersonic Reacting Flow around Blunt Bodies显示文摘The effects of chemical reactions in the hypersonic reacting flow are investigated using an integrated algorithm considering simultaneously two different reaction mechanisms,i.e.,including the high temperature air nonequilibrium chemical reactions and the H_2-air combustion reactions. The program is validated by the air non-equilibrium flow at Mach number of 25.9 with the RAM C-II configuration and the shock-induced combustion flow at Mach number of 4.512 6 around a sphere,respectively. Furthermore,the mixed reacting flow with the Mach number of 10.0 with an opposing jet of hydrogen is numerically analyzed. The results show that the program is reliable,and the effects of chemical reactions engender in the decrease of peak temperature along characteristic lines,as well as on the surface. The production of water is augmented in the region with high ratio of oxygen to hydrogen and weakened in the area with low ratio of oxygen to hydrogen by the air chemical non-equilibrium effects. | ZHAO Faming WANG Jiangfeng FAN Xiaofeng YANG Tianpeng | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，1： | 0 |
| 15 | Simultaneous structure and luminescence property control of barium carbonate nanocrystals through small amount of lanthanide doping显示文摘Rare earth doping has been widely applied in many functional nanomaterials with desirable properties and functions,which would have a significant effect on the growth process of the materials.However,the controlling strategy is limited into high concentration of lanthanide doping,which produces concentration quenching of the lanthanide ion luminescence with an increase in the Ln^(3+)concentration,resulting in lowering the fluorescence quantum yield of lanthanide ion.Herein,for the first time,we demonstrate simultaneous control of the structures and luminescence properties of BaCO_3nanocrystals via a small amount of Tb^(3+)doping strategy.In fact,Tb^(3+)would partially occupy Ba^(2+)sites,resulting in the changes to the structures of the BaCO_3nanocrystals,which is primarily determined by charge modulation,including the contributions from the surfaces of crystal nuclei and building blocks.These structurally modified nanocrystals exhibit tunable luminescence properties,thus emerging as potential candidates for photonic devices such as light-emitting diodes and color displays. | Jianmin Gu Zhenpan Bian Baipeng Yin Cuihong Jin Xin Liu Yahui Gao Jingxiao Wu Shoufeng Tang Faming Gao Yong Sheng Zhao | 2017 | Science Bulletin2017，62，18： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员