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您的检索式：作者名="Francesca Fagiani"
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| 1 | Immune response in COVID-19:addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2显示文摘To date,no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive treatments.Therefore,based on the fast and global spread of the virus,urgent investigations are warranted in order to develop preventive and therapeutic drugs.In this regard,treatments addressing the immunopathology of SARS-CoV-2 infection have become a major focus.Notably,while a rapid and well-coordinated immune response represents the first line of defense against viral infection,excessive inflammatory innate response and impaired adaptive host immune defense may lead to tissue damage both at the site of virus entry and at systemic level.Several studies highlight relevant changes occurring both in innate and adaptive immune system in COVID-19 patients.In particular,the massive cytokine and chemokine release,the so-called“cytokine storm”,clearly reflects a widespread uncontrolled dysregulation of the host immune defense.Although the prospective of counteracting cytokine storm is compelling,a major limitation relies on the limited understanding of the immune signaling pathways triggered by SARS-CoV-2 infection.The identification of signaling pathways altered during viral infections may help to unravel the most relevant molecular cascades implicated in biological processes mediating viral infections and to unveil key molecular players that may be targeted.Thus,given the key role of the immune system in COVID-19,a deeper understanding of the mechanism behind the immune dysregulation might give us clues for the clinical management of the severe cases and for preventing the transition from mild to severe stages. | Michele Catanzaro Francesca Fagiani Marco Racchi Emanuela Corsini Stefano Govoni Cristina Lanni | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 2 | Molecular regulations of circadian rhythm and implications for physiology and diseases显示文摘The term'circadian rhythms'describes endogenous oscillations with ca.24-h period associated with the earth’s daily rotation and light/dark cycle.Such rhythms reflect the existence of an intrinsic circadian clock that temporally orchestrates physiological processes to adapt the internal environment with the external cues. | Francesca Fagiani Daniele Di Marino Alice Romagnoli Cristina Travelli Davide Voltan Lorenzo Di Cesare Mannelli Marco Racchi Stefano Govoni Cristina Lanni | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 3 | Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2显示文摘An elegant paper by Yuan et al.,recently published in Science,provides novel insights into the molecular features of neutralizing antibody responses to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Francesca Fagiani Michele Catanzaro Cristina Lanni | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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