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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | SOX2,a persistent marker for multipotential neural stem cells derived from embryonic stem cells,the embryo or the adult显示文摘 | Ellis P Fagan B M Magness S T | | 0，，24： | 2 |
| 3 | Crown ether-doped sol-gel materiaIs for strontium( 1I ) separation显示文摘 | YOST T L Jr FAGAN B C ALLAIN L R | 2000 | Analytical Chemis- try2000，72，21： | 1 |
| 4 | Relationship between dispersion metric and properties of PMMA/SWNT nanoc0mposites显示文摘 | Kashiwagi T Fagan J Douglas J F | 2007 | Polymer2007，48，16： | 1 |
| 5 | A review of anti-VEGF agents for proliferative diabetic retinopathy 显示文摘 | Osaadon P Fagan XJ Lifshitz T | 2014 | Eye ( brad )2014，28，5： | 1 |
| 6 | Phase distribution identification in the column leaching of low grade ores using MRI显示文摘 | FAGAN M A SEDERMAN A J HARRISON S T L JOHNS M L | 2013 | Minerals Engineering2013，48，： | 1 |
| 7 | A review of anti-VEGF agents for proliferative diabetic retinopathy显示文摘 | Osaadon P Fagan XJ Lifshitz T | 2014 | Eye (Lond)2014，28，5： | 1 |
| 8 | Sulfur isotope systematics and platinum group elements behavior in REE-enriched metasomatic fluids: A study of mantle xenoliths from Dish Hill, California, USA显示文摘 | WILSON M R KYESER T K FAGAN R | 1996 | Geochim Cosmochim Acta1996，61，： | 1 |
| 9 | Molecular evolvtion of the Ca2+-binding photoproteins of the hydrozoa 显示文摘 | TSUJI F I OHMIYA Y FAGAN T F | 1995 | Photochem Photobiol1995，62，4： | 1 |
| 10 | SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem ceils, the embryo or the adult 显示文摘 | Ellis P Fagan B M Magness S T | 2004 | Dev Neurosci2004，26，： | 1 |
| 11 | Northwest Africa 773:Lunar origin and iron-enrichment trend显示文摘 | Fagan T J Taylor G J Keil K | | 0，，4： | 1 |
| 12 | Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension显示文摘 | Nagaoka T Fagan KA Gebb SA | 2005 | AmJ Respir Crit Care Med2005，171，5： | 1 |
| 13 | Effect of freeze-chilling, in comparison with fresh, chilling and freezing, on some quality parameters of raw whiting, mackerel and salmon portions 显示文摘 | Fagan J D Gormley T R Mhuircheartaigh M U | 2003 | Lebensm Wiss Technol2003，36，7： | 1 |
| 14 | The semantics of space: experiential and linguistic aspects of selected English spatial terms 显示文摘 | Pollio H R Fagan L B Graves T R | 2005 | Journal of Psycholinguistic Research2005，34，2： | 1 |
| 15 | Effect of modified atmosphere packaging with freeze-chilling on some quality parameters of raw whiting, mackerel and salmon por- tionsI显示文摘 | Fagan J D Gormley T R Ui Mhuircheartaigh M M | 2004 | Innovative Food Science - Emerging Technologies2004，5，2： | 1 |
| 16 | Growth rate- stoichiometry couplings in diverse biota 显示文摘 | Elser JJ Acharya K Kyle M Cotner J Makino W Markow T Watts T Hobbie S Fagan W Schade J Hood J Sterner RW | 2003 | Ecol Lett2003，6，10： | 1 |
| 17 | A review of anti-VEGF agents for proliferative diabetic retinopathy显示文摘 | Osaadon P Fagan XJ Lifshitz T | 2014 | Eye (Lond)2014，28，5： | 1 |
| 18 | Minocycline to improve neurologic outcome in stroke (MINOS) :a dose-finding study显示文摘 | Fagan S C Waller J L Nichols F T Edwards D J Pett- igrew L C Clark W M | 2010 | Stroke2010，41，： | 1 |
| 19 | Effect of modified atmosphere packaging with freeze -chilling on some quality parameters ofraw whiting, mackerel and salmon portions 显示文摘 | Fagan J D Gormley T R | 2004 | Innovative Food Science and Emerging Technologies2004，5，： | 1 |
| 20 | Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension显示文摘 | Nagaoka T Fagan KA Gebb SA | 2005 | Am J Respir Crit Care Med2005，171，5： | 1 |
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