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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 3 | 瑞士马铃薯晚疫病监测及决策支持系统PhytoPRE + 2000在网络上的实现(英文)显示文摘1990年以来 ,瑞士在全国范围内保留了一些不经防治的马铃薯田并设立了晚疫病监测网。商品生产基地马铃薯晚疫病的首次侵染信息被用来指导防治区域性病害。近 12年期间 ,有 10年晚疫病始发于 5月份 ,其中 9年是由保护地扩散到大田的。从 2 0 0 1年起 ,农民们能够在网络上得到PhytoPRE +2 0 0 0决策支持系统的服务。系统的核心是国家范围晚疫病发生的实际状态、过去及未来的天气预报资料。用晚疫病菌侵染和产孢所需的关键性气象条件 (MISP)来衡量未来天气状况的满足程度。自 1996年至 2 0 0 0年 ,MISP模型被用来指导田间晚疫病的防治。与PhytoPRE +95相比 ,在多雨年份防治次数未能减少 ,但是在干旱年份能节省 40 %以上的药剂使用。在田间试验当中 ,MISP模型在指导首次用药方面与PhytoPRE +95不相上下 ,在连续用药方面优于其它决策支持系统。在 1999年和 2 0 0 0年 ,MISP模型被整合到PhytoPRE +2 0 0 0决策支持系统。为了使信息快速传递 ,采用了网络技术。PhytoPRE+2 0 0 0是一个针对特定区域和特定地块并集建议、信息和预警为一体的决策支持系统。每日的实际病害发生图以及通过MISP预测的晚疫病发生预警图能够通过网络显示给瑞士所有马铃薯种植户。 | FORRER H R STEENBLOCK T FRIED P M | 2001 | 河北农业大学学报2001，24，2： | 2 |
| 4 | Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study显示文摘 | Daniel Von Renteln Karl–Hermann Fuchs Paul Fockens Peter Bauerfeind Melina C. Vassiliou Yuki B. Werner Gerald Fried Wolfram Breithaupt Henriette Heinrich Albert J. Bredenoord Jan F. Kersten Tessa Verlaan Michael Trevisonno Thomas R?sch | 2013 | Gastroenterology2013，，2： | 2 |
| 5 | Probable involvement of thaxtomins A in pathogenicity of Streptomyces scabies on seedlings显示文摘 | LEINER R H FRY B A CARLING D E | 1996 | Phytopathology1996，86，： | 2 |
| 6 | Antibiotic Resistance in Salmonella Isolates from Imported Chicken Carcasses in Bhutan and from Pig Carcasses in Vietnam显示文摘 | Ellerbroek L Narapati D Tai N Phu Poosaran N Pinthong R Sirimalaisuwan A Tshering P Fries R Zessin K-h Baumann M Schroeter A | 2010 | Journal of Food Protection2010，，2： | 2 |
| 7 | A simple and general method for transferring genes into plants显示文摘 | FRY J E HOFFMANN N L | 1985 | Science1985，217，： | 1 |
| 8 | Chromosomal localization of the major histocompatibility complex of the horse ( ELA ) by in situhybridization显示文摘 | Ansari H A Hediger R Fries R | 1988 | Immunogenetics1988，28，： | 1 |
| 9 | Coordinating Production and Delivery under a (z ,Z)-Type Vendor-Man-aged Inventory Contract 显示文摘 | Fry M J Kapuscinski R Olsen T L | 2001 | Manufacturing & Service Operations Management2001，3，2： | 1 |
| 10 | Development of a quan titative real-time detection assay for hepatitis B virus DNA and comparison with two commercial assay s显示文摘 | Pas sd Fries E De Man R A | 2000 | Clin Microbiol2000，39，8： | 1 |
| 11 | Delivery of substances into cells and tissues using a particle bombardment process 显示文摘 | Horsch R B Fry J E Hoffmann N L | 1987 | Part Sci Techn1987，5，1： | 1 |
| 12 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 13 | Using floating catchment analysis (FCA) techniques to examine intra -urban variations in accessibility to public trans- port opportunities: the example of Cardiff, Wales 显示文摘 | Langford M Higgs G Fry R | 2012 | Journal of Transport Geography2012，25，： | 1 |
| 14 | Assessment of the gene content of the chromosomal regions flanking bovine DGAT1显示文摘 | WINTER A ALZINGER A FRIES R | 2004 | Genomics2004，83，1： | 1 |
| 15 | Structure of chlorotrifluoroethylene/vinylidene fluoride Random copolymers and homopolymers by molecular dynamics simulations显示文摘 | Gee R H Fried L E Cook R C | 2001 | Macromolecules2001，34，： | 1 |
| 16 | A century of ramjet propulsion technology evolution显示文摘 | Fry R S | 2004 | Journal of Propulsion and Power2004，20，1： | 1 |
| 17 | A simple and general method for transferring genes into plants, Science显示文摘 | Fry T E Hoffmann N L | 1995 | (227): 1227 - 12311995，，227： | 1 |
| 18 | A simple and general method for transferring genes into plants 显示文摘 | Horsch R B Fry J E Hoffmann N L | 1985 | Science1985，227，： | 1 |
| 19 | A simple and general method for transferring genes into plants显示文摘 | Horsch R B Fry J E Hoffmann N L | 1985 | Sci- ence1985，227，： | 1 |
| 20 | Pharmacologic treatment of consti-pation:what is new显示文摘 | Pohl D Tutuian R Fried M | | 0，，06： | 1 |
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