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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Neuroanatomy of lower gastrointestinal pain disorders显示文摘Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the intestines,the peripheral and the central nervous system.In this article we review how the sensory nerve information from the healthy and the hypersensitive bowel is encoded and conveyed to the brain.The gut milieu is continuously monitored by intrinsic enteric afferents,and an extrinsic nervous network comprising vagal,pelvic and splanchnic afferents.The extrinsic afferents convey gut stimuli to second order neurons within the superficial spinal cord layers.These neurons cross the white commissure and ascend in the anterolateral quadrant and in the ipsilateral dorsal column of the dorsal horn to higher brain centers,mostly subserving regulatory functions.Within the supraspinal regions and the brainstem,pathways descend to modulate the sensory input.Because of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to induce sensation or pain.In inflammatory bowel disease(IBD)and irritable bowel syndrome(IBS)patients,however,long-term neuroplastic changes have occurred in the brain-gut axis which results in chronic abdominal pain.This sensitization may be driven on the one hand by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resident macrophages,neurons and smooth muscles.On the other hand,neuronal synaptic changes along with increased neurotransmitter release in the spinal cord and brain leads to a state of central wind-up.Also life factors such as but not limited to inflammation and stress contribute to hypersensitivity.All together,the degree to which each of these mechanisms contribute to hypersensitivity in IBD and IBS might be diseaseand even patient-dependent.Mapping of sensitization throughout animal and human studies may significantly improve our understanding of sensitization in IBD and IBS.On the long run,this knowledge can be put forward in potential therapeutic targets for abdominal pain in these conditions. | Wim Vermeulen Joris G De Man Paul A Pelckmans Benedicte Y De Winter | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 3 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017，25，4： | 5 |
| 4 | Pesticide food safety standards as companions to tolerances and maximum residue limits显示文摘Allowable levels for pesticide residues in foods,known as tolerances in the US and as maximum residue limits(MRLs) in much of the world,are widely yet inappropriately perceived as levels of safety concern. A novel approach to develop scientifically defensible levels of safety concern is presented and an example to determine acute and chronic pesticide food safety standard(PFSS) levels for the fungicide captan on strawberries is provided. Using this approach,the chronic PFSS level for captan on strawberries was determined to be 2 000 mg kg–1 and the acute PFSS level was determined to be 250 mg kg–1. Both levels are far above the existing tolerance and MRLs that commonly range from 3 to 20 mg kg–1,and provide evidence that captan residues detected at levels greater than the tolerance or MRLs are not of acute or chronic health concern even though they represent violative residues. The benefits of developing the PFSS approach to serve as a companion to existing tolerances/MRLs include a greater understanding concerning the health significance,if any,from exposure to violative pesticide residues. In addition,the PFSS approach can be universally applied to all potential pesticide residues on all food commodities,can be modified by specific jurisdictions to take into account differences in food consumption practices,and can help prioritize food residue monitoring by identifying the pesticide/commodity combinations of the greatest potential food safety concern and guiding development of field level analytical methods to detect pesticide residues on prioritized pesticide/commodity combinations. | Carl K Winter Elizabeth A Jara | 2015 | Journal of Integrative Agriculture2015，14，11： | 3 |
| 5 | Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘 | Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B | 2000 | Plant Cell2000，12，9： | 2 |
| 6 | Soil microarthropods in longterm no-tillage and conventional corn production显示文摘 | Winter J P Voroney R P Ainsworth D A | 1990 | Canadian Journal of Soil Science1990，70，： | 1 |
| 7 | Photoinhibition and zeaxanthin formation in intact leaves, a possible role of the xanthophylls cycle in the dissipation of excess light energy 显示文摘 | Demmig B Winter K Kruger A | 1987 | Plant Physiol1987，84，： | 1 |
| 8 | Three-dimensional wave instability near a critical layer显示文摘 | Winters K B D' asaro E A | 1994 | Joumal of Fluid Mechanics1994，272，： | 1 |
| 9 | Affordances in Situation Theory 显示文摘 | Lenari A Winter M | 2013 | Ecological Psychology2013，25，2： | 1 |
| 10 | P2Y1 receptor antagonists as novel antithrombotic agents 显示文摘 | Jeffrey A Pfefferkorn Chulho Choi Thomas Winters | 2008 | Bioorganic & Med Chem Lett2008，18，11： | 1 |
| 11 | Kinetic analysis of the lower limbsduring walking:What information can be gained from athree-dimensional model显示文摘 | Eng J J Winter D A | 1995 | Biomech1995，28，6： | 1 |
| 12 | Assessment of the gene content of the chromosomal regions flanking bovine DGAT1显示文摘 | WINTER A ALZINGER A FRIES R | 2004 | Genomics2004，83，1： | 1 |
| 13 | Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival显示文摘 | HANLY A M REDMOND M WINTER D C | 2006 | Br J Cancer2006，94，9： | 1 |
| 14 | Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase(DGAT1) with variation at a quantitative trait locus for milk fat content显示文摘 | Winter A Kramer W Werner F A at al | 2002 | Proc Natl Sci USA2002，99，14： | 1 |
| 15 | Plasm a N-Teminal pro-B-type naturetic peptide for prediction of death or nonfatal myocardial infarction following percutancous coronary intervention显示文摘 | De winter RJ'strobants A Koch KT | 2004 | Am J Cantial2004，94，12： | 1 |
| 16 | Graphites for lithium-ion cells:the correlation of the first-cycle charge loss with the brunauer-emmett-teller surface area显示文摘 | Winter M Novak P Monnier A | 1998 | J Electrochemical Society1998，145，2： | 1 |
| 17 | Graphites for lithium-ion cells:the Correlation of the first-cycle charge loss with the Brunauer-Emmett-Teller surface area显示文摘 | WINTER M NAVAK P MONNIER A | 1998 | J Electrochem Soc1998，145，： | 1 |
| 18 | Urban heat island effect analysis for San Juan, Puerto Rico 显示文摘 | Velazquez Lozada A Gonzalez J E Winter A | 2006 | Atmospheric Environment2006，40，： | 1 |
| 19 | Pathways forconversion of char nitrogen to nitric oxide during pulver-ized coal combustion 显示文摘 | Molina A Murphy J J Winter F | 2009 | Combustion and Flame2009，156，3： | 1 |
| 20 | Plasma N-terminal proB-type natriuretic peptide for prediction of death or nonfatal myocardial infarction following percutaneous coronary intervention显示文摘 | de Winter RJ Stroobants A Koch KT | 2004 | Am J Cardiol2004，94，12： | 1 |
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