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| 1 | Pancreatitis: Preventing catastrophic haemorrhage显示文摘Pancreatitis represents nearly 3% of acute admissions to general surgery in United Kingdom hospitals and has a mortality of around 1%-7% which increases to around 10%-18% in patients with severe pancreatitis. Patients at greatest risk were those identified to have infected pancreatic necrosis and/or organ failure. This review seeks to highlight the potential vascular complications associated with pancreatitis that despite being relatively uncommon are associated with mortality in the region of 34%-52%. We examine the current evidence base to determine the most appropriate method by which to image and treat pseudo-aneurysms that arise as the result of acute and chronic inflammation of pancreas. We identify how early recognition of the presence of a pseudo-aneurysm can facilitate expedited care in an expert centre of a complex pathology that may require angiographic, percutaneous, endoscopic or surgical intervention to prevent catastrophic haemorrhage. | Richard PT Evans Moustafa Mabrouk Mourad Gunraj Pall Simon G Fisher Simon R Bramhall | 2017 | World Journal of Gastroenterology2017，23，30： | 6 |
| 2 | 高热致胚胎发育毒性机理的研究——热休克蛋白合成显示文摘按Kimmel实验条件热暴露孕10天大鼠。暴露后2小时取胚胎用^(35)S—蛋氨酸标记,SDS—PAGE蛋白分析,可见70和90KilodaltonKD热休克蛋白合成增加。70KD HSP合成用Westernblot分析又进一步得到证实。离体培养胚胎热暴露后,用同样方法分析蛋白,证实70和90KD HSPs合成增加。结果与Kimmel骨骼畸形和胚胎体节融合发生率相符合。本结果为German提出的环境致畸机理假说提供了依据。 | 芦春林 C A Kimmel G L Kimmel D J Heredia B R Fisher N T Brown | 1993 | 北京医科大学学报1993，25，6： | 4 |
| 3 | 烟草角斑病和野火病显示文摘 | Fisher,R 杨献营 | 1991 | 国外烟草1991，，1： | 2 |
| 4 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 5 | Shear strength of stud connectors in lightweight and normaldensity concrete显示文摘 | OLLGAARD J G SLUTTER R G FISHER J W | 1971 | Eng J AISC1971，7，1： | 2 |
| 6 | A generalized assignment heuristic for vehicle routing显示文摘 | Fisher M L Jaikumar R | 1981 | Networks1981，11，2： | 2 |
| 7 | 治疗选择偏倚的存在与观察性研究分析:使用倾向积分法和工具变量法评价心脏介入治疗对AMI存活的影响显示文摘背景:对观察性研究中治疗与未治疗患者的结果进行比较时,由于患者预后存在组间差异,因此可发生偏倚,后者常常是因为存在未予观察的治疗选择偏倚。
目的:对下列4种去除观察性研究选择偏倚的分析方法进行比较:多变量模型危险校正法(muhivariable model risk adjustment)、倾向积分危险校正法(propensity score risk adjustment)、倾向匹配法(propensity—based matching)以及工具变量分析法(instrumental variable analysis)。
设计、地点及患者:122124例因急性心肌梗死(AMI)而于1994~1995年住院的、接受医疗保险的老年(年龄65~84岁)患者全国队列。这些患者适合心脏导管检查。基线图表审查取自心血管协作项目并与医疗保险健康管理数据联合以便提供系列预后变量。患者随访7年(至2001年12月31日)以便评估长期存活与住院30天内心脏导管检查两者的关系。
主要观测指标:使用各种分析方法获得的危险校正后相对死亡率。
结果:与未接受心导管检查的患者相比,接受心导管检检查的患者较年轻而且急性心肌梗死的严重度较低。采用标准的统计学危险校正法校正预后因素后,心导管检查与死亡率相对下降50%相关(多变量模型危险矫正法:校正后相对危险度[relative risk,RR],〉0.51;95%可信区间[confidence interval,CI],0.50~0.52。倾向积分危险校正法:校正后RR,0.54;95%CI,0.53~0.55]。倾向配对法:校正后RR,0.54;95%CI,0.52~0.56)。使用局部插管作为一种工具,工具变量分析显示死亡率相对下降16%(校正后RR,0.84;95%CI,0.79~0.90)。随机临床试验中常规介入治疗的生存获益在8%和21%之间。
结论:心导管检查与急性心肌梗死长期死亡率的关系对分析方法高度敏感。对于去除未测量的治疗选择偏倚而言,各种标准危险校正方法具有同样的局限。与标准建模法比较,工具变量分析法可以减少治疗效果偏倚。但是相对于特殊的临床问题,该法更适合回答政策策略问题。 | Thérèse A. Stukel Elliott S. Fisher David E. Wennberg 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，6： | 2 |
| 8 | 健康无症状受试者与无腰椎手术史慢性腰背痛患者腰椎拉伸强度的比较显示文摘腰背痛(low back pain,LBP)在急性期可自行恢复,但有相当一部分患者发展为慢性腰背痛(chronic low back pain,CLBP)。腰伸肌肌肉组织功能失调被认为是腰背部损伤和疼痛的危险因素之一,在CLBP发展进程中扮演一定角色。 | Conway R Behennah J Fisher J 王万舜 夏虹 | 2018 | 中国骨科临床与基础研究杂志2018，10，3： | 2 |
| 9 | A controlled clinical trial of high -dose methylprednisolone in the treatment of severe sepsis and septic shock显示文摘 | Bone R C Fisher C J Clemmer T P | 1987 | N Engl J Med1987，317，： | 2 |
| 10 | Object reconstruction by incorporating geometric constraints in reverse engineering显示文摘 | Werghi N Fisher R Robertson C | 1999 | Computer-Aided Design1999，31，6： | 1 |
| 11 | Nutrient limitation of phytoplankton in Chesapeake Bay显示文摘 | FISHER T R DEELE E R AMMERMAN T W | 1992 | Marine Ecological Progress Series1992，82，1： | 1 |
| 12 | Water-rock interaction in Tertiary sandstone,San Jeoquin Basin,Californa,USA:Diagenetic control on water composition显示文摘 | Fisher J B Boles J R | 1990 | Chemical Geology1990，82，： | 1 |
| 13 | Shear Streng'th of Stud Connectors in Lightweight and Normal Weight Concrete 显示文摘 | Ollgaard J G Slutter R G Fisher J W | 1971 | AISC Eng J1971，8，2： | 1 |
| 14 | Right lobe living donor liver transplantation显示文摘 | Marcos A Fisher R A Ham J M | 1999 | Transplantation1999，68，6： | 1 |
| 15 | Reducing the PAPR of multiearrier modulation by seleeted mapping显示文摘 | Bauml R W Fisher R H | 2000 | IEEE Transactions on Communication2000，32，1： | 1 |
| 16 | A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer显示文摘 | Chapuis PH Dent OF Fisher R | 1985 | BJS1985，72，： | 1 |
| 17 | Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss:Early treatment diabetic retinopathy study report 18显示文摘 | Davis M D Fisher M R Gangnon R E | 1998 | Invest Ophthalmol Vis Sci1998，39，： | 1 |
| 18 | The Sensitivity of Two Distributed Non-point Ssource Pollution Models to the Spatial Arrangement of the Landscape显示文摘 | Fisher P Abrahart R J Herbinger W | 1997 | Hydrol Process1997，，11： | 1 |
| 19 | Photic-and pattern-induced seizures: a review of the epilepsy foundation of america working group 显示文摘 | FISHER R S HARDING G ERBA G | 2005 | Epilepsia2005，46，9： | 1 |
| 20 | Reynolds stress and TKE production in an estuary with a tidal bore显示文摘 | SIMPSON J H FISHER N R WILES P | 2004 | Estuarine Coastal and Shelf Science2004，60，4： | 1 |
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