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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Adenocarcinoma of the third and fourth portions of the duodenum: The capsule endoscopy value显示文摘Primary adenocarcinoma of the small intestine occurs in over 50% of cases in the duodenum. However,its location in the third and fourth duodenal portions occurs rarely and is a diagnostic challenge. The aim of this work is to report an adenocarcinoma of the third and fourth duodenal portions,emphasizing its diagnostic difficulty and the value of video capsule endoscopy. A man,40 years old,with no medical history,with abdominal discomfort and progressive fatigue,presented four months ago with one episode o f m o d e ra t e m e l e n a. T h e p hy s i c a l e x a m i n a t i o n was normal,except for mucosal pallor. Blood tests were consistent with microcytic,hypochromic iron deficiency anemia with 7.8 g/d L hemoglobin. The upper and lower endoscopy were normal. Additional work-up with video capsule endoscopy showed a polypoid lesion involving the third and fourth portions o f t h e d u o d e n u m. B i o p s y s h o w e d a m o d e ra t e l y differentiated adenocarcinoma. Abdominal computed tomography showed a wall thickening from the third duodenal portion to the proximal jejunum,without distant metastasis. The patient underwent segmental resection(distal duodenum and proximal jejunum) with duodenojejunostomy. The surgical specimen histology confirmed the biopsy diagnosis,with transmural infiltration,without nodal involvement. Conclusion: Adenocarcinoma of the third and fourth portions of the duodenum is difficult to diagnose and capsule endoscopy is of great value. | Feliciano Chanana Paquissi Ana Henriqueta Filipe Bunga Pimentel Lima Maria de Fátima do Nascimento Vieira Lopes Francisco Viamontes Diaz | 2015 | World Journal of Gastroenterology2015，21，31： | 2 |
| 3 | Electrical spin injection and accumulation at room temperature in an all-metal mesoscopic spin valve显示文摘 | Filip A T van Wees B J | 2001 | Nature2001，410，： | 1 |
| 4 | A further study about the behavior of foundation piles and beams in a Winkler-Pasternak soil 显示文摘 | Filipic P F Rosalesa M B | 2002 | Inter- national Journal of Mechanical Sciences2002，44，1： | 1 |
| 5 | Is there a com- promise between nutrient uptake and gas exchange in the gut of Misgurnus anguillicaudatus, an intestinal air-breathing fish?显示文摘 | Goncalves A F Filipe L Cristina C | 2007 | Comparative Biochemistry and Physiology Part D: Genomics and Proteomics2007，2，34： | 1 |
| 6 | Vanadium haloperoxidases from brown algae of the Laminariaceae family显示文摘 | Almeida M Filipe S Humanes M Maia M F Melo R Severino N Da Silva J A L Da Silva J J R F Wever R | 2001 | Phytochemistry2001，57，： | 1 |
| 7 | Modern sports eye injuries显示文摘 | Capao Filipe J A Rocha-Sousa A Falcao-Reis F | 2003 | Bn J Ophthalmol2003，87，11： | 1 |
| 8 | Carbon nanotube field-effect transistor detector associated to gas chromatography for speciation of benzene, toluene, ethylbenzene, ( o-, m- and p-) xylene 显示文摘 | LURDES I B S FILIPE D P F TERESA A P R S | 2009 | Journal of Chromatography A2009，1216，37： | 1 |
| 9 | Contextual factors and the creativity of frontline employee:the mediating effects of role stress and intrinsic motivition显示文摘 | FILIPE C MARIO A LUIS F L | 2011 | Journal of Retailing2011，87，1： | 1 |
| 10 | Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer: preliminary data from a prospective study from three centres显示文摘 | Filipe MI Potet F Bogomoletz MV | 1985 | Gut1985，26，12： | 1 |
| 11 | Disruption of circadian coordination and malignant growth 显示文摘 | Filip ski E Li XM Levi F | 2006 | Cancer Causes Control2006，17，50： | 1 |
| 12 | Current management of postoperative chylothorax显示文摘 | HOSSEIN F FILIP PC MASSIMO AM | 2001 | Ann Thorac Surg2001，71，： | 1 |
| 13 | The blood enz ymatic antiodative potential in bronchial asthma patients显示文摘 | FILIP F BRANISTEANU D POPOVICI I | 1999 | Rev Med Chir Soc M ed Nat Iasi1999，103，34： | 1 |
| 14 | Clinical and bacterio- logical effects of pivmeci显示文摘 | Filip J Niels F M Ingegerd S | 2013 | Journal of Antimicrobial Chemotherapy2013，69，3： | 1 |
| 15 | Assessment of autonomic function in high level athletes by pupillometry显示文摘 | Filipe JA Falc? o-Reis F Castro-Correia J | 2003 | Autonomic Neuro science:Basic and Clinical2003，104，1： | 1 |
| 16 | Sim ultaneous determination of pesticide and antibiotic residues at trace level in water samples by SPE and LC-MS/MS显示文摘 | FILIPE F MAGALI K JANICE D | 2012 | Brazilian Journal of Analyti- cal Chemistry2012，2，7： | 1 |
| 17 | Supply of cooling and heating with solar assisted absorption heat pumps:an energetic approach显示文摘 | Filipe Mendes L Collares-Pereira M Ziegler F | 1998 | Int J Rerig1998，21，2： | 1 |
| 18 | Electrical spin injection and accumulation at room temperature in an all-metal meso- scopie spin valve 显示文摘 | Jedema F Filip A Van Wees B | 2001 | Nature2001，410，6826： | 1 |
| 19 | Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil显示文摘AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible gaps.METHODS A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as 'low'(0-28 correct answers) or 'desirable'(29-46 correct answers). Associations between sociodemographic characteristics and perception were also evaluated.RESULTS A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas. | Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos Jurema Corrêa da Mota Filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar | 2018 | World Journal of Hepatology2018，10，11： | 1 |
| 20 | Dose-dependent response FGF-2 for lymphangiogenesis显示文摘 | Lynn K Guillermo G Filip F | 2004 | Proc Natl Acad Sci2004，101，11： | 1 |
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