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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Phosphorus Use Efficiency of Bio-Based Fertilizers:Bioavailability and Fractionation显示文摘Although to date some technologies producing bio-based phosphorus(P) fertilizers have been proposed and implemented, the efficient use of the recovered products is still limited due to legislative constraints and lack of insights in the P release with time and in the corresponding mechanisms. The aim of this work was to evaluate the fertilizer performance in terms of P release and use efficiency of recovered struvite, FePO_4-sludge, digestate, and animal manure as compared to fossil reserve-based mineral triple superphosphate(TSP). First, product physicochemical characteristics and P fractions in the context of European fertilizer legislation were assessed. Next, a controlled greenhouse experiment was set up to evaluate plant reactions as well as changes of P availability in a sandy soil with high P status and a Rheinsand soil with low P status. Soil P fractions were determined in the extracts with water, ammonium lactate and CaCl_2, and in soil solution sampled with Rhizon soil moisture samplers. Based on all results, it is worth conducting long-term field trials to evaluate the P release effect of struvite and digestate as compared to animal manure and TSP on different soil types with varying P status. These products showed promise as sustainable substitutes for conventional P fertilizers and could contribute to a more efficient use of P in agriculture. A refined classification of P application standards/recommendations in terms of soil P status, soil texture, and fertilizer characteristics, next to the crop P demand, is recommended. Moreover, the additional use of Rhizon samplers for determination of direct available P, including dissolved organic P, is proposed for better understanding and categorization of different P fertilizers in environmental and fertilizer legislations. | Céline VANEECKHAUTE Joery JANDA Peter A.VANROLLEGHEM Filip M.G.TACK Erik MEERS | 2016 | Pedosphere2016，26，3： | 3 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | Short mucin 1 alleles are associated with low virulent H pylori strains infection显示文摘TO THE EDITOR We read with interest the article published by Nguyen et al[1] in the World Journal of Gastroenterology, | Bárbara Peleteiro Nuno Lunet Filipe Santos-Silva Leonor David Céu Figueiredo Henrique Barros | 2007 | World Journal of Gastroenterology2007，13，12： | 3 |
| 5 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | War Sci Technol1999，39，1： | 1 |
| 6 | Postcholecystectomy syndrome an algorithmic approach显示文摘 | Filip M Saftoiu A Popescu C | 2009 | Gastrointestin Liver Dis2009，18，1： | 1 |
| 7 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | Water Science and Technology1999，39，1： | 1 |
| 8 | Peroxidase-like activity of llex paraguariensis 显示文摘 | ANESINI C FERRARO G FILIP R | 2006 | Food Chemistry2006，97，3： | 1 |
| 9 | Postcholecystectomy syndromes-an algorithmic approach 显示文摘 | Filip M Saftoiu A Popescu C | 2009 | J Gastrointestin Liver Dis2009，18，1： | 1 |
| 10 | An expeditious method for the determination of organochlorine pesticides residues in estuarine sediments using microwave assisted pre-extraction and automated headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry 显示文摘 | Pedro N C Pedro N R Filipe A Rafael E Maria C P Teresa M V | 2008 | Talanta2008，76，5： | 1 |
| 11 | pH as a key factor in the competition between glycogen-accumulating organisms and phosphorus-accumulating organisms显示文摘 | Filipe Carlos D M Daigger Glen GradyT C P Leslie | 2001 | Water Environment Research2001，73，2： | 1 |
| 12 | A metabolic model for acetate uptake under anaerobic con- ditions by glycogen accumulating organisms: stoichiom- etry, kinetics, and the effect of pH 显示文摘 | FILIPE C D M DAIGGER G T GRADYC PL | 2001 | Biotechnology and Bioengineering2001，76，： | 1 |
| 13 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | Water Science & Technology1999，39，1： | 1 |
| 14 | Effects of pH on the rates of aerobic metabolism of phospho- rus-accumulating and glycogen-accumulating organ- isms显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Water Environment Research2001，73，： | 1 |
| 15 | Hyperhomocysteinemia is an indicator of oxidant stress显示文摘 | Albu E Filip C Zamosteanu N | 2012 | Med Hypotheses2012，78，4： | 1 |
| 16 | Total polyphenol content and antioxidant capacity of commercially available tea in Argentina显示文摘 | Anesini C Ferraro G E Filip R | 2008 | J Agric Food Chem2008，56，19： | 1 |
| 17 | Stoichiometry and kinetics of acetate uptake under anaerobic conditions by an enriched culture of phosphorus-accumulating organisms at different pHs显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Biotechnology Bioengineering2001，76，1： | 1 |
| 18 | Discrimination of bark from wood chips through texture analysis by image processing显示文摘 | James R Wooten SD Filip TO C Igathinathang | 2011 | Computers and Electronics in Agriculture2011，79，1： | 1 |
| 19 | Characterization of the denitrifying fraction of phosphate accumulating organisms in brological phosphate removal process显示文摘 | Meinhold J Filipe C D M Dagger G T | 1999 | Wat Sci-Tech1999，39，1： | 1 |
| 20 | Ozonation of a landfill leachate: evaluation of toxicity removal and biode gradability improvement显示文摘 | BILA D M FILIPE M A SILVA A C | 2005 | Journal of Hazardous Materi als2005，117，2： | 1 |
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