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| 1 | Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury显示文摘Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/ARDS.Herein,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of inflammation.Dexamethasone acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site.The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of mice.RNA sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways.These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS. | Zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou Gao | 2022 | Bioactive Materials2022，7，8： | 5 |
| 2 | Regulation of phenylpropanoid biosynthesis by MdMYB88 and MdMYB124 contributes to pathogen and drought resistance in apple显示文摘MdMYB88 and MdMYB124 have been demonstrated to be responsible for lignin accumulation in apple under drought stress.In this study,using a metabolomic approach,we identified differentially accumulated phenylpropanoid and flavonoid metabolites in MdMYB88/124 transgenic RNAi plants under control and long-term drought stress conditions in apple roots.We confirmed the regulation of phenylalanine by MdMYB88 and MdMYB124 via UPLC-MS in apple roots under both control and drought conditions.Using Electrophoretic Mobility Shift Assay(EMSA)and ChIPquantitative PCR(qPCR)analyses,we found that MdMYB88 positively regulates the MdCM2 gene,which is responsible for phenylalanine biosynthesis,through binding to its promoter region.Under long-term drought conditions,MdMYB88/124 RNAi plants consistently accumulated increased amounts of H2O2 and MDA,while MdMYB88 and MdMYB124 overexpression plants accumulated decreased amounts of H2O2 and MDA.We also examined the accumulation of metabolites in the phenylpropanoid biosynthesis pathway in the leaves of MdMYB88 and MdMYB124 transgenic apple plants after long-term drought stress.We found that metabolites responsible for plant defense,including phenylpropanoids and flavonoids,accumulated less in the RNAi plants but more in the overexpression plants under both control and drought conditions.We further demonstrated that MdMYB88/124 RNAi plants were more sensitive to Alternaria alternata f.sp.mali and Valsa mali,two pathogens that currently severely threaten apple production.In contrast,MdMYB88 and MdMYB124 overexpression plants were more tolerant to these pathogens.The cumulative results of this study provided evidence for secondary metabolite regulation by MdMYB88 and MdMYB124,further explained the molecular roles of MdMYB88 and MdMYB124 in drought resistance,and provided information concerning molecular aspects of their roles in disease resistance. | Dali Geng Xiaoxia Shen Yinpeng Xie Yusen Yang Ruiling Bian Yuqi Gao Pengmin Li Liying Sun Hao Feng Fengwang Ma Qingmei Guan | 2020 | Horticulture Research2020，7，1： | 5 |
| 3 | 0il bleed from elastomeric thermal silicone conductive pads显示文摘 | Yuqi Chen Yakai Feng Jingqi Zhao Jingbo Shen Menghuang Feng | 2016 | Frontiers of Chemical Science and Engineering2016，10，4： | 3 |
| 4 | Simple and Sensitive Determination of Aromatic Acids in Coconut Water by g-C3N4@SiO2 Based Solid-phase Extraction and HPLC-UV Analysis显示文摘 | QIANGBA Gezhen ZHU Gangtian YU Qiongwei FENG Yuqi | 2018 | Chemical Research in Chinese Universities2018，34，4： | 3 |
| 5 | Screening of amino acids in dried blood spots by stable isotope derivatization-liquid chromatography-electrospray ionization mass spectrometry显示文摘Direct infusion mass spectrometry(DIMS) is a powerful technique in clinical diagnosis for screening neonatal amino acid metabolic disorders from dried blood spots(DBS).However,DIMS sometimes generated false-positive results for analysis of amino acids.In this work,we utilized a stable isotope derivatization method,combining with liquid chromatography tandem mass spectrometry(SID-LC-MS),to improve the specificity for screening amino acids in DBS specimens.A pair of isotope reagents,p-(dimethylamino)phenyl isothiocyanate(DMAP-NCS) and 4-isothiocyanato-N,N-bis(methyl-[2H2])aniline([2H4]DMAP-NCS),was synthesized and used to label amino acids in DBS specimens.The [2H4]DMAP-NCS labelled amino acid standards were used as internal standards to compensate the matrix effect.This method was validated by measuring linearity,recovery and accuracy.The results showed that the developed SID-LC-MS method can be used for sensitive and selective determination of 12 diagnostically important amino acids in DBS specimens. | Huaming Xiao Ping Liu Shujian Zheng Xian Wang Jun Ding Yuqi Feng | 2020 | Chinese Chemical Letters2020，31，9： | 3 |
| 6 | Interleukin-6 signaling pathway in targeted therapy for cancer显示文摘 | Yuqi Guo Feng Xu TianJian Lu Zhenfeng Duan Zhan Zhang | 2012 | Cancer Treatment Reviews2012，，7： | 2 |
| 7 | Study on the relationship between chromatographic retention behaviour and molecular structure显示文摘 | Feng Yuqi Zhu Pengling Hu Zhide | 1988 | Chromatographia1988，，5： | 2 |
| 8 | Analytical methods for locating modifications in nucleic acids显示文摘In addition to the canonical nucleobases, a variety of chemical modifications have been identified presence in nucleic acids. These modifications have been demonstrated to involve in regulating the spatiotemporal expression of genes. Up to date, over 150 types of chemical modifications have been found existence in nucleic acids. Understanding the functional roles of modifications relies on deciphering the location information of modifications in nucleic acids. Analytical methods for studying nucleic acid modifications have greatly advanced in the last decade. To locate the modifications in nucleic acids, various mass spectrometry (MS)-based analytical strategies have been established. Recent progress in next-generation sequencing (NGS) in conjugation with immunoprecipitation, chemical reaction, enzyme-mediated mutation, or nanomaterials offer genome-wide or transcriptome-wide mapping of modifications, which greatly revolutionize the field of epigenetic modifications. Herein, we reviewed and summarized the established methods and the breakthrough of the techniques for locating modifications in nucleic acids. In addition, we discussed the principles, applications, advantages and drawbacks of these methods. We believe that with the rapid advancement of techniques and methods,the functions of nucleic acid modifications will be fully understood in the future. | Chubo Qi Jianghui Ding Bifeng Yuan Yuqi Feng | 2019 | Chinese Chemical Letters2019，30，9： | 2 |
| 9 | OsCBL1 Modulates Lateral Root Elongation in Rice via Affecting Endogenous Indole-3-Acetic Acid Biosynthesis显示文摘Root growth is important for plants to efficiently acquire water and mineral nutrients from soil.Root system architecture(RSA),which is determined mainly by root branching through lateral root formation and root angles,has a significant influence on root growth.Generally,the growth and development of roots are regulated by numerous plant hormones,which respond to external environmental stimulation through com- | Jing Yang Xiaomu Zhang Yunqing Huang Yuqi Feng Yangsheng Li | 2015 | Journal of Genetics and Genomics2015，42，6： | 2 |
| 10 | Separation and purification of phosphatidylcholine and phosphatidylethanolamine from soybean degummed oil residues by using solvent extraction and column chromatography显示文摘 | Weinong Zhang Haibo He Yuqi Feng Shilu Da | 2003 | Journal of Chromatography B2003，，2： | 2 |
| 11 | Separation and purification of phosphatidylcholine and phosphatidyle- thanolamine from soybean degummed oil residues by using solvent extraction and column chromatography 显示文摘 | ZHANG Weinong HE Haibo FENG Yuqi | 2003 | J Chro- matogr B Analyt Technol Biomed Life Sci2003，798，2： | 1 |
| 12 | The influence of the metal net charge of non-metallocene early transition metal catalyst on the ethylene polymerization activity显示文摘The net charges on central metals of a serial non-metallocene early transition metal catalysts (FI catalyst) with similar steric hindrance were caculated with MM-QEq (molecular mechmism-charge equilibration) method and associated with ethylene polymerization activities of these FI catalyts. It was found that the activity increased with the net charge on metal if ignoring the influence of the steric hindrance. In other words, introduction of strong and/or more electron-withdrawing groups onto the ligand of FI catalyst would enhance the activity of the catalyst. This conculsion gave a direction to designing new FI catalyst with higher activity. | WU ChunHong LI HuaYi FENG YuQi HU YouLiang | 2008 | Chinese Science Bulletin2008，53，20： | 1 |
| 13 | Characteristics of Uranium Mineralization in Red Clastic Formations in the Southwestern Margin of the Ordos Basin显示文摘In the southwestern margin of the Ordos Basin,uranium mineralization is primarily hosted by predominantly oxidative red clastic formations in the Lower Cretaceous.The main target layers for uranium exploration are the Madongshan and Liwaxia formations of the Liupanshan Group,followed by the Jingchuan Formation of the Zhidan Group.The host rocks(medium-fine feldspar quartz sandstone),which are bleached to a light grayish white color,contain a minor organic matter component and pyrite.Uranium mineralization changes from surficial infiltration or phreatic oxidation in the upper part to interlayer oxidation in the lower part.Uranium ore bodies are mostly lenticular or tabular in shape,locally shaped like crescent rolls.Individual ore bodies are typically small and shallow.Uranium predominantly manifests as pitchblende and coffinite.Coffinite is usually short and columnar or granular in habit,whereas pitchblende occurs as an irregular colloidal covering on the surface or in fissures of ferric oxide,silicate,clay or carbonate.Secondary uranium minerals are torbernite,uranophane,and uranopilite.Minerals associated with uranium are mainly pyrite,chalcopyrite and,to a minor extent,arsenopyrite and fluorite.The associated elements are Mo,V,Se,Co,Ni,and Mn,the host sandstone being high in Cu and Ba.Overall,the red clastic formations in the southwestern margin of the Ordos Basin are characterized by’five multiples but one low’which means multiple target layers,multiple stages of mineralization,multiple ore body shapes,multiple kinds of uranium minerals,multiple associated elements,but low organic matter.This implies an overall complex uranium metallogenic environment and mineralization process.It is recommended that future uranium exploration should take into consideration regional metallogenic conditions and mineralization features,with target layers in the wide-smooth synclinal slope being focused on.Most uranium deposits are small to medium in size,and the main type of uranium mineralization can vary by target layer. | ZHANG Zilong HE Feng YI Longsheng FAN Honghai CAI Yuqi LIU Hongxu LIU Xinyang CHEN Hongbin JIA Cui YANG Mengjia | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 14 | Temperature-response polymer coating for in-tube solid-phase microextraction coupled to high-performance liquid chromatography 显示文摘 | YU Qiongwei MA Qiao FENG Yuqi | 2011 | Talanta2011，84，4： | 1 |
| 15 | Preparation of porous carbon-silica composite monoliths显示文摘 | Shi ZhiGuo Feng YuQi Xu Li | 2003 | Carbon2003，41，13： | 1 |
| 16 | Profiling of Permeable Compounds in Ligusticum chuanxiong by Biopartitioning Micellar Chromatography显示文摘 | Zhixiong Hu Weinong Zhang Haibo He Yuqi Feng Shilu Da | 2009 | Chromatographia (-)2009，，7： | 1 |
| 17 | Formation of an anticyclonic eddy and the mechanism involved: a case study using cruise data from the northern South China Sea显示文摘Data from satellite altimetry and in situ observations together with the Hybrid Coordinate Ocean Model (HYCOM) reanalysis data were used to investigate the mechanism and formation of an anticyclonic eddy in the northeastern South China Sea (SCS). Analysis of water mass using cruise data indicated that the water captured in the eddy diff ers from those in the SCS, the Kuroshio intrusion, and the eddy-forming region. Data from sea surface height (SSH) and sea level anomaly (SLA) indicate that the eddy formed due both to the Kuroshio intrusion and the local circulation in the SCS. The Kuroshio intrusion is present at the start of the eddy growth (March 5-9) before Kuroshio leaps the Luzon Strait. The eddy then becomes larger and stronger in the absence of the Kuroshio intrusion. From the eddy budget of the HYCOM reanalysis data, the formation of the eddy goes in three steps. By the third step, the eddy had become aff ected by variations of local SCS circulation, which is more strongly than in the fi rst step in which it is aff ected more by the Kuroshio intrusion. The variability of the temperature and salinity inside the eddy provide a support to this conclusion. The water in the SCS intruded into the eddy from the southeast, which decrease the salinity gradually in the southern part of the eddy during the growth period. | HOU Huaqian XIE Qiang XUE Huijie SHU Yeqiang NAN Feng YIN Yuqi YU Fei | 2019 | Journal of Oceanology and Limnology2019，37，5： | 1 |
| 18 | 内侧缰核胆碱能神经元GABAB受体通过突触前兴奋作用调控动物恐惧记忆显示文摘动物的生存依赖于将预警信号和危险联系起来.对预警信号形成恐惧记忆,以便提前做出反应。当预警信号不再与危险相关时,动物逐渐解除这种联系,消退恐惧记忆,以适应新的生存环境。恐惧记忆消退缺陷被认为和人类创伤后应激障碍(PTSD)等精神障碍有紧密关系。目前关于动物恐惧记忆的研究主要集中在杏仁核及其相关脑区。 | 张举恩 Lubin Tan Yuqi Ren Jingwen Liang Rui Lin Qiru Feng Jingfeng Zhou Fei Hu Jing Ren Chao Wei Tao Yu Yinghua Zhuang Bernhard Bettler Fengchao Wang 罗敏敏 | 2017 | 科学新闻2017，19，4： | 1 |
| 19 | Polymermonolith microextraction online coupled to hydrophilicinteraction chromatography/mass spectrometry for a-nalysis ofβ2-agonist in human urine显示文摘 | Zheng Mingming Zhang Manyu Feng Yuqi | 2009 | J Sep Sci2009，32，11： | 1 |
| 20 | Extraction of clen-buterol from urine using hydroxylated poly(glycidylmethacrylate-co-ethylene dimethacrylate)monolithmicroextraction followed by high-performance liquidchromatography determination显示文摘 | Wen Yi Wang Ying Feng Yuqi | 2007 | J Sep Sci2007，30，17： | 1 |
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