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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Transobturator vaginal tape inside out procedure for stress urinary incontinence:results of patient显示文摘 | Feng CL Chin HY Wang KH | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，10： | 1 |
| 3 | IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: A cohort study 显示文摘 | Kao JT Feng CL Yu CJ | 2015 | Bmc Gastroenterology2015，，1： | 1 |
| 4 | Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration显示文摘 | Decanini A Nordgaard CL Feng X | 2007 | Am J Ophthalmol2007，143，4： | 1 |
| 5 | Endoscopic ligation and resection for the treatment of small EUS-suspected gastric GI stromal tumors 显示文摘 | HUANG WH FENG CL LAI HC | 2010 | Gastrointestinal Endoscopy2010，71，6： | 1 |
| 6 | Methylphenidate enhances NMDAreceptor response in medial prefrontal cortex via sigma-l receptor: a novel mechanism for methylphenidate action 显示文摘 | Zhang CL Feng ZJ Liu Y | 2012 | PLoS One2012，7，12： | 1 |
| 7 | Clinical analysis of eetopic pancreas with endoscopic ultrasonography: an experience in a medical center 显示文摘 | Chen SH Huang WH Feng CL | 2008 | J Gastreintest Surg2008，12，5： | 1 |
| 8 | Regulation of cell growth by selective COX-2 inhibitors in oral carcinoma cell lines显示文摘 | Yang CY Feng CL Liao CL | 2003 | Prostaglandins Other Lipid Mediat2003，72，6： | 1 |
| 9 | Simultaneous liv er kidney transplantation:evaluation to decision making显示文摘 | Davis CL Feng S Sung R | 2007 | Am J Transplant2007，7，： | 1 |
| 10 | Real-time magnetic resonance imaging for interventional neuroradiological procedures显示文摘 | Schumacher HC Dumoulin CL Feng L | 2003 | Surg Technol Int2003，11，： | 1 |
| 11 | 查看详情显示文摘 | Feng X.J Zhou W.Z Li Y.G Ke H.S. Tang J.K. Clérac R. Wang Y.H. Su Z.M. Wang E B | | 0，，： | 1 |
| 12 | Expression and purification of an antimicrobial peptide, bovine lactoferricin derivative LfeinB-W10 in Escherichia coli 显示文摘 | Feng XJ Liu CL Guo JY | 2010 | Curr MicrobioiL2010，60，3： | 1 |
| 13 | Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration显示文摘 | Decanini A Nordgaard CL Feng X | | 0，，4： | 1 |
| 14 | MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells显示文摘 | Feng YH Wu CL Shiau AL | 2012 | Int J Mol Med2012，29，5： | 1 |
| 15 | Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells显示文摘 | Feng YH Tsao CJ Wu CL | 2010 | Cancer Sci2010，101，9： | 1 |
| 16 | High-level expression and purification of Tat-haFGF19-154显示文摘 | Huang Y Rao YL Feng CL | 2008 | Appl Mierobiol Biotechnol2008，77，5： | 1 |
| 17 | Transfermoral catheterization of carotid arteries with real-time MR imaging guidance in pigs显示文摘 | Feng L Dumoulin CL Dashnaw S | 2005 | Radiology2005，234，： | 1 |
| 18 | Effect of POX3 Gene Disruption Using Self-cloning CRF1 Cassette in Yarrowia lipolytica on the γ-decalactone production显示文摘 | Guo YQ Feng CL Song HL | 2011 | World Journal of Microbiology and Biotechnology2011，27，12： | 1 |
| 19 | Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration 显示文摘 | Deeanini A Nordgaard CL Feng X | 2007 | Am J Ophthalmol2007，143，： | 1 |
| 20 | Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration 显示文摘 | Nordgaard CL Karunadharma PP Feng X | 2008 | Invest Ophthalmol Vis Sci2008，49，： | 1 |
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