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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Blood neuron-specific enolase in newborns with perinatal asphyxia 显示文摘 | Verdu Perez A Falero MP Arroyos A Estevez F Felix V Lopez Y | 2001 | Rev Neurol2001，32，8： | 1 |
| 3 | There was a factor increases growth hormone levels in the rat显示文摘 | Frantz A V Heimer E P Felix A M | 1964 | Proc Natl Acad Sei USA1964，91，78： | 1 |
| 4 | Peripheral osteoma of the mandibular condyle显示文摘 | J C M A Mancini M Woltmann V B Felix | 2005 | Journal of the Chinese Medical Association2005，34，1： | 1 |
| 5 | Granular flows in a rotating drum: The scaling law between velocity and thickness of the flow 显示文摘 | FELIX G FALK V D’Ortona U | 2007 | Eur Phys J E2007，22，1： | 1 |
| 6 | Laparo- scopic vs conventional tension free inguinal herniorrha- phy:2005 society of American Gastrointestinal Endo- scopic Surgeons (SAGES) annual meeting debate 显示文摘 | PURI V FELIX E FITZGIBBONS R J Jr | 2006 | Surg Endosc2006，20，： | 1 |
| 7 | A centered hot plate method for measurement of thermal properties of thin insula- ting materials 显示文摘 | Jannot Y Felix V Degiovanni A | 2010 | Measurement Science and Technology2010，21，3： | 1 |
| 8 | Simvastain decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats 显示文摘 | Giusti--Paiva A Martinez M R Felix J V | 2004 | Shock2004，21，3： | 1 |
| 9 | 查看详情显示文摘 | Yanovsky V Felix C Mourou G | | 0，，： | 1 |
| 10 | Multiresidue determination of tetracyclines,sulphonamides and chloramphenicol in bovine milk using HPLC-DAD显示文摘 | Monica C V M Felix GRR Sunsanne R | 2009 | Food Chemistry2009，117，3： | 1 |
| 11 | Natural frequencies ofthin rectangular plates with holes or orthotropic patchescarrying an elastically mounted mass显示文摘 | Bambill D V Felix D H Rossit C A | 2006 | InternationalJournal of Solids and Structures2006，43，1415： | 1 |
| 12 | Driving with Tentacles:Integral Structures for Sensing and Motion显示文摘 | Felix V H Michael H Falk H | 2008 | Journal of Field Robotics2008，25，9： | 1 |
| 13 | Trends in polymer electrolytes for secondary lithium batteries显示文摘 | Felix B D Lambertus P Jakobert B J V | 2000 | J Power Sources2000，88，2： | 1 |
| 14 | Dandy-Walker malformation in an infant with tetrasomy 9p显示文摘 | Cazorla Calleja MR Verdu A Felix V | 2003 | Brain Dev2003，25，3： | 1 |
| 15 | Laparoscopic vs conventional tension free inguinal herniorrhaphy: 2005 society of American Gastrointestinal Endoscopic Surgeons (SAGES) annum meeting debate显示文摘 | Puri V Felix E Fitzgibbons RJ Jr | 2006 | Surg Endosc2006，20，12： | 1 |
| 16 | Supercritical CO2/ethanol extraction of astaxanthin from blue crab (Callinectes sapidus) shell waste 显示文摘 | Felix V L Higuera C I Goycoolea V F | 2001 | J Food Proc Eng2001，24，2： | 1 |
| 17 | Removal of a foreign body from the upper gastrointestinal tract with a flexible endoscope : a prospective study 显示文摘 | Chaves D M Ishioka S Felix V N | 2004 | Endoscopy2004，36，10： | 1 |
| 18 | Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency显示文摘 | PETER H G M FEDERIC A V FELIX D | 2008 | Cell Calcium2008，44，1： | 1 |
| 19 | Determination of Glyphosate residues in plants by precolumn derivatization and coupled-column liquid chromatography with fluorescence detection显示文摘 | Felix Hernandez Carmen Hidalgo Juan V Sancho | 2003 | Journal of AOAC INTERNATIONAL2003，83，3： | 1 |
| 20 | Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats显示文摘 | GIUSTI-PAIVA A MARTINEZ M R FELIX J V | 2004 | Shock2004，21，3： | 1 |
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