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| 1 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 2 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences 显示文摘 | Strausberg R L Feingold E A Grouse L H | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 3 | Gender difference in personaliy:A meta-analysis显示文摘 | Feingold A | 1994 | Psychology Bulletin1994，116，： | 1 |
| 4 | Gender differences in personality: a metal-anal ysis 显示文摘 | Feingold A | 1994 | Psychological Bulletin1994，，116： | 1 |
| 5 | Reduced Leptin levels in starvation increase susceptibility to endotoxic shock显示文摘 | Faggioni R Moser A Feingold K R | 2000 | Am J Pathol2000，156，： | 1 |
| 6 | Thiazolidinedione use and bone loss in older diabetic adults显示文摘 | Schwartz A V Sellmeyer D E Vittinghoff E Palermo L Lecka-Czernik B Feingold K R | 2006 | J Clin Endocrinol Metab2006，91，： | 1 |
| 7 | Cryopreser-vation of human platelets using6% dimethyl sulfoxide and storage at -80℃显示文摘 | Carciero R Feingold H | 1985 | Vox Sang1985，49，： | 1 |
| 8 | The effects of cytokines on intermediary metabolism 显示文摘 | Memon R A Feingold K R Grunfeld C | 1994 | Endocrinologolog1994，4，： | 1 |
| 9 | Sex differences in variability intellectual abilities:A new look at an old controversy显示文摘 | FEINGOLD A | 1992 | Review of Educational Research1992，62，1： | 1 |
| 10 | 显示文摘 | K R Feingold C Grunfeld | 1994 | Endocrinologolog1994，4，： | 1 |
| 11 | Gener- ation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences显示文摘 | Strausberg R L Feingold E A Grouse L H | 2002 | Proc Natl Acad Sci U S A2002，99，16： | 1 |
| 12 | Reduced leptin levels in starvation increase susceptibility to endotoxic shock显示文摘 | Faggioni R Moser A Feingold K R | 2000 | Am J Pathol2000，156，5： | 1 |
| 13 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 14 | Major abdominalsurgery increases plasma levels of vascular endothelial growthfactor:Open more so than minimally invasive methods显示文摘 | Belizon A Balik E Feingold DL | 2006 | Ann Surg2006，244，： | 1 |
| 15 | Cognitive Gender Differences Are Disappearing 显示文摘 | Feingold A | 1988 | American Psychologist1988，，43： | 1 |
| 16 | Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences显示文摘 | Strausberg R L Feingold E A Grouse L H | 2002 | PNAS2002，99，16： | 1 |
| 17 | Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates显示文摘 | BERGMAN H FEINGOLD A NINI A | 1998 | Trends Nenrosci1998，21，1： | 1 |
| 18 | Major abdominal surgery increases plasma levels of vascular endothelial growth factor: open more so than minimally invasive methods显示文摘 | Belizon A Balik E Feingold DL | 2006 | Ann Surg2006，244，5： | 1 |
| 19 | Inflammation stimu- lates niacin receptor(GPR109A/HCA2) expression in adipose tissue and macrophages显示文摘 | Feingold KR Moser A Shigenaga JK | 2014 | Journal of Lipid Research2014，55，12： | 1 |
| 20 | Gender differences in personality: A meta-analysis显示文摘 | Feingold A | 1994 | Psychological Bulletin1994，116，3： | 1 |
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