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| 1 | 铁岭组钾质斑脱岩锆石SHRIMP U-Pb年代学研究及其地质意义显示文摘最近在冀北-辽西以碳酸盐岩为主的铁岭组内发现了钾质斑脱岩,并获得其锆石SHRIMP U-Pb年龄——(1437±21)Ma,这一进展将铁岭组的时代确定为中元古代早期盖层纪(Calymmian Period)末期.与此同时,还在同一剖面获得了铁岭组的上覆地层——下马岭组碳硅质页岩里钾质斑脱岩锆石SHRIMPU-Pb年龄——(1372±18)Ma,这与稍早前在北京西北及其附近地区所获得的定年结果(~1380Ma)是一致的.这在肯定了该地区下马岭组应归入中元古代中期延展纪(Ectasian Period)早期的同时,也表明以蓟县剖面为代表的燕山东部地区铁岭组-下马岭组等相关序列,可与北京西山及燕山西部进行良好对比.换言之,华北北部从高于庄组到铁岭组的巨厚碳酸盐岩序列都应视为中元古界盖层系沉积,而铁岭组与下马岭组之间的不整合面可作为中元古界盖层系与延展系之间的物理性分界标志;早先以该不整合面命名的'芹峪上升'(或'芹峪运动')应属于一个时限短暂的中元古代早期的区域抬升,不能再视为华北克拉通对新元古代罗迪尼亚超大陆聚合事件(~1.0Ga)的响应. | 苏文博 李怀坤 HUFF W D ETTENSOHN F R 张世红 周红英 万渝生 | 2010 | 科学通报2010，55，22： | 88 |
| 2 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 3 | 62 kaBP以来湖光岩玛珥湖沉积物有机碳同位素记录及古气候环境意义显示文摘湖光岩玛珥湖HUG B孔岩心记录了62kaBP以来的古气候、古环境变化信息。全岩有机碳同位素组成(δ13CTOC)分析表明,62kaBP以来δ13CTOC值变化比较明显,其变化范围为-28.5‰~-15.5‰。结合孢粉和有机地球化学指标进行综合分析,湖光岩玛珥湖δ13CTOC变化曲线可划分为6个演化阶段:62~58和48~40.5kaBP两个时段的δ13CTOC值偏负,沉积物中有机质主要来源于热带—亚热带地区的陆生C3森林植被,反映了温暖潮湿的气候环境;58~48和40.5~17.2kaBP期间δ13CTOC值明显偏正,沉积物中有机质主要源自C4草本植物,反映了湖光岩地区有效降水量减少、干旱程度增加导致湖光岩玛珥湖湖面下降,大量C4草本植物生长在暴露的湖滨岸;17.2~4kaBP时段内δ13CTOC值尽管存在更加频繁的波动,但总体呈现逐渐偏负的趋势,反映了暖湿和冷干气候多次交替但总体上逐渐变暖、变湿的气候环境;4kaBP以来δ13CTOC值存在逐渐偏正的趋势,虽然不排除人类活动的影响,但很可能反映了干旱程度的再次增加。综合分析表明,有效降水量(降水量-蒸发量)是控制湖光岩玛珥湖地区C3/C4植物相对生物量变化的主导因素。湖光岩玛珥湖有机碳同位素的研究结果支持区域气候环境而不是大气CO2浓度变化是末期冰期以来热带低纬度地区C3/C4植被相对生物量变化的主要原因。 | 刘强 顾兆炎 刘嘉麒 游海涛 吕厚远 储国强 祁向雷 Jorg F W Negendank Jens Mingram Georg Schettler | 2005 | 海洋地质与第四纪地质2005，25，2： | 34 |
| 4 | SHRIMP U-Pb dating for a K-bentonite bed in the Tieling Formation,North China显示文摘A SHRIMP U-Pb zircon age of 1437±21 Ma was obtained for a recently discovered K-bentonite bed in the Tieling Formation,situated northeast of Beijing at the boundary between Liaoning and Hebei provinces,on the northern margin of the North China Craton(NCC).The SHRIMP U-Pb age places Tieling Formation near the end of the Calymmian Period of the early Mesoproterozoic Era.In addition,a SHRIMP U-Pb zircon date of 1372±18 Ma was acquired for K-bentonite beds in the overlying,dark-shale-dominated Xiamaling Formation from the same location northeast of Beijing.This date assigns a similar Mid-Mesoproterozoic(Ectasian Period) age for the Xiamaling Formation,as have previously determined dates from other sections northwest of Beijing.These dates indicate that the Tieling and Xiamaling formations,as well as the related succession in the eastern part of the Yanshan Mountains,represented by the well-known Meso-to Neoproterozoic standard section in Jixian,can be correlated well with sections northwest of Beijing in the western part of the Yanshan Mountains.In other words,the boundary between the Calymmian and Ectasian periods in the northern parts of the NCC is marked by the unconformity between the Tieling and Xiamaling formations in the northern NCC.This boundary was previously ascribed to the 'Qinyu Orogeny' and thought to be of Grenville age.In this regard,the conventional 'Qinyu Orogeny' should now be regarded as a short-lived regional uplift during Early Mesoproterozoic time,rather than a result from the Grenvillian assembly of the NCC to the Rodinia Supercontinent(~1.0 Ga). | SU WenBo LI HuaiKun HUFF W D ETTENSOHN F R ZHANG ShiHong ZHOU HongYing WAN YuSheng | 2010 | Chinese Science Bulletin2010，55，29： | 30 |
| 5 | Ⅰ期癌症患者切除淋巴结内隐匿性微小转移癌灶的检查及其临床病理意义显示文摘目的 检查癌症患者切除淋巴结内有无微小癌转移 ,具有临床、病理重要性。方法 350例 期癌症患者包括非小细胞肺癌 94例 ,乳腺癌 112例 ,食管癌 115例及外阴癌 2 9例病理报告无癌转移的淋巴结 3715枚。应用单克隆抗细胞角蛋白 ( AE1/ AE3)、抗上皮细胞膜 ( EMA) ,及多克隆抗角蛋白抗体进行免疫组化染色重新检查。结果 所有病例的 32 .3% ( 113/ 350 )、被检淋巴结的 5.5%( 2 0 3/ 3715)有淋巴结内隐匿性肿瘤转移。肺癌患者及被检淋巴结的阳性率均比其他肿瘤高。肺鳞癌58%、腺癌 53.8%的淋巴结为阳性 ,分别比食管鳞癌 2 2 .5%、外阴鳞癌 10 .3%及乳腺癌 2 7.7%高 ( P<0 .0 5)。部分乳腺癌患者术后随访显示 :淋巴结阳性患者比阴性者预后更差 ( P<0 .0 5)。结论 说明免疫组化技术可大大提高淋巴结微小癌转移的检出率 ,其阳性率的不同可能与患者的临床经过甚至癌患者的死亡率相关联。 | 陈朝伦 卢晓梅 黄绒 黎音 古丽娜尔 沈宝茵 A J Cochran D R Wen W F Coulson | 1997 | 中华肿瘤杂志1997，19，1： | 16 |
| 6 | What is artificial meat and what does it mean for the future of the meat industry?显示文摘The meat industry cannot respond to increases in demand by ever increasing resource use. The industry must find solutions to issues regarding animal welfare, health and sustainability and will have to do so in the face of competition from emerging non-traditional meat and protein products in an increasingly complex regulatory environment. These novel meat and protein products, otherwise known as ‘artificial meat' are utilising ground breaking technologies designed to meet the issues facing the conventional meat industry. These artificial meats, in vitro or cultured meat and meat from genetically modified organisms have no real capacity to compete with conventional meat production in the present environment. However, meat replacements manufactured from plant proteins and mycoproteins are currently the biggest competitors and are gaining a small percentage of the market. Manufactured meats may push conventional meat into the premium end of the market, and supply the bulk, cheap end of the market if conventional meat products become more expensive and the palatability and versatility of manufactured meats improve. In time the technology for other artificial meats such as meat from genetic modified organisms or cultured meat may become sufficiently developed for these products to enter the market with no complexity of the competition between meat products. Conventional meat producers can assimilate agroecology ecology concepts in order to develop sustainable animal production systems. The conventional meat industry can also benefit from assimilating biotechnologies such as cloning and genetic modification technologies, using the technology to adapt to the changing environment and respond to the increasing competition from artificial meats. Although it will depend at least partly on the evolution of conventional meat production, the future of artificial meat produced from stem cells appears uncertain at this time. | Sarah P F Bonny Graham E Gardner David W Pethick Jean-Franois Hocquette | 2015 | Journal of Integrative Agriculture2015，14，2： | 15 |
| 7 | New Development of Acid Regeneration in Steel Pickling Plants显示文摘For acid pickling heat treated mild steel and steel products, up to the middle of the last century, sulfuric acid was primarily in use, which has been replaced stepwise by hydrochloric acid since the sixties. During this time, the pickling of high alloyed steel with hydrofluoric acid or mixtures for hydrofluoric acid together with nitric acid has also been applied on industrial scale. The technologies used by several plant contractors hereby show considerable differences in their engineering.The study provides a survey of the progress in the state of art of regeneration tech- nology as well as the use of different pickling media in the form of a review on existing technologies as well as im- provements done within the recent years in the area. | W F Kladnig | 2008 | Journal of Iron and Steel Research(International)2008，15，4： | 15 |
| 8 | Comeld^TM Joints: A Novel Technique for Bonding Composites and Metal显示文摘Current and future structural applications for composite laminates frequently involve design solutions combining composite laminates and metal; the materials must be joined. Two conventional means of joining are available mechanical joining and adhesive bonding. Both methods have critical disadvantages. A novel surface treatment for metals developed at TWI, Surfi-Sculpt, leads to the formation of surface protrusions on metal surfaces. These protrusions are typically 1.0 mm high and 0.6 mm in diameter. The surface modified metal can be bonded with composite laminates to form a Comeld~TM joint. These joints can be described as a combination of mechanical fastening and adhesive bonding. This paper describes our current work using finite element modelling to optimize the protrusions in respect to their geometry and distribution. The simulations require multi-scale modelling techniques to transfer results between the global model of the whole joint and the unit cell models containing a protrusion. Results from the simulations show critical effects on stress distributions arising from changing protrusion geometry. These joints show significant advantages over conventional adhesive joining technologies and their application would allow improved performance for combinations of metal and composite laminates. | Tu W Guild F J Hogg P J | 2009 | 稀有金属材料与工程2009，38，A03： | 14 |
| 9 | 生物质燃烧颗粒物的定量分析和化学形态显示文摘用电子探针技术开展单个含钾颗粒物的分析表征 .第一种方法用蒙特卡洛方法模拟电子束与样品复杂的相互作用 ,对于KCl晶粒取得的计算结果与理论值一致 .K/Cl比的均值为 0 996 ,标准偏差为 0 0 1 2 .由于晶形不规则和热稳定性差 ,K2 SO4 和KHSO4 的结果没有达到KCl的准确度 .其K/S比的均值和标准偏差分别为 1 90 5±0 0 1 3和 1 0 1 4± 0 0 72 .第二种方法用回归分析方法处理了同一种类若干数目的颗粒物分析数据 .直接用同种类标准颗粒物的分析结果校准 ,进行定量分析和化学形态识别 .研究结果表明 ,非洲草原大火燃烧排放时 ,含钾颗粒经历了逐步酸化的过程 .在排放时主要以KCl形态存在 ,少量是K2 SO4 和复盐 .在大气传输过程中逐渐酸化 ,主要转变成KHSO4 .少量停空时间长的颗粒则继续酸化 ,成为高度富硫的颗粒 . | 刘咸德 李玉武 董树屏 Van EspenP Adams F Maenhaut W | 2002 | 环境化学2002，21，3： | 13 |
| 10 | 恶性弥漫型腱鞘滑膜巨细胞肿瘤显示文摘 | Li C F Wang J W Huang W W 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，4： | 12 |
| 11 | New insights in the treatment of acromioclavicular separation显示文摘A direct force on the superior aspect of the shoulder may cause acromioclavicular(AC) dislocation or separation. Severe dislocations can lead to chronic impairment, especially in the athlete and high-demand manual laborer. The dislocation is classified according to Rockwood. Types Ⅰ?and Ⅱ are treated nonoperatively, while types Ⅳ, Ⅴ and Ⅵ are generally treated operatively. Controversy exists regarding the optimal treatment of type Ⅲ dislocations in the high-demand patient. Recent evidence suggests that these should be treated nonoperatively initially. Classic surgical techniques were associated with high complication rates, including recurrent dislocations and hardware breakage. In recent years, many new techniques have been introduced in order to improve the outcomes. Arthroscopic reconstruction or repair techniques have promising short-term results. This article aims to provide a current concepts review on the treatment of AC dislocations with emphasis on recent developments. | Christiaan J A van Bergen Annelies F van Bemmel Tjarco D W Alta Arthur van Noort | 2017 | World Journal of Orthopedics2017，8，12： | 12 |
| 12 | bFGF and heparin but not laminin are necessary factors in the mediums that affect NSCs differentiation into cholinergic neurons显示文摘 | Ren W Guo Q Yang Y Chen F | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 13 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 14 | 偏振模色散(PMD)论述显示文摘本文描述了偏振模色散(PMD)的成因及其统计特性。并针对偏振模色散对模拟和高比特率数字通信系统的影响进行了详细的讨论。光纤和光缆的测量结果表明,为了在光缆中得到合理的光纤偏振模色散值,适当地选取测量状态是很重要的。如果规定允许的偏振模色散最大值为05ps/km,则可以保证偏振模色散不会对下一代数字通信系统产生影响。 | 杨日胜 FSchank WRenken | 1996 | 光纤与电缆及其应用技术1996，，3： | 8 |
| 15 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 16 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 17 | 血小板反应蛋白1和核因子κB信号通路在婴幼儿血管瘤抗血管生成中的作用显示文摘背景:普萘洛尔是治疗婴幼儿血管瘤的一线药物,但其作用机制仍不清楚。核因子κB在肿瘤中高表达,直接或间接促进血管生成。血小板反应蛋白1是体内最重要的抗血管生成蛋白,这些蛋白质介导信号通路,可能在血管瘤治疗中发挥重要作用。本研究探讨了血小板反应蛋白1和核因子κB信号通路在普萘洛尔治疗血管瘤中的协同调节作用。 | Xu W Li S Yu F 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，5： | 7 |
| 18 | 16年随访的前瞻性队列中521120名个体的膳食脂肪摄入与总死亡率和特定原因死亡率的关系显示文摘饱和脂肪摄入与心血管健康相关性的证据存在争议。不饱和脂肪和总死亡率及心血管病死亡率的相关性存在不一致性,并且关于非心血管病死亡率的数据较少。该文旨在评估膳食脂肪与总死亡率和特定原因死亡率的关系。方法和结果:研究者分析了来自随访16年的美国国立卫生研究院一美国退休人员协会膳食与健康研究年龄50~71岁的参与者521 120人的数据。通过食品频率问卷评估饱和脂肪酸(saturatedfatty acid,SFA )、反式脂肪酸(trans-fatty acid,TFA)、单不饱和脂肪酸(monounsaturated fatty acid,MUFA)与多不饱和脂肪酸(polyunsaturated fattyacid,PUFA)的摄入量。 | 陈嘉睿(译) 练桂丽(审校) Zhuang P Zhang Y He W Chen X Chen J He L Mao L Wu F Jiao J | 2019 | 中华高血压杂志2019，27，4： | 7 |
| 19 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 20 | 澳大利亚肉类标准和分级体系显示文摘澳大利亚肉类标准(meat standards Australia,MSA)是一个肉类全面质量管理系统,旨在为消费者提供一个肉类食用品质的准确描述。MSA已经通过对消费者进行大规模的品尝实验,确定了牛肉供应链中影响牛肉可口性的生产、屠宰、加工和价值以及各个生产环节的关键控制点(critical control points,CCPs)评分。这些关键控制点评分通过两种方式管理牛肉的可口性。首先,屠宰加工领域的关键控制点一直作为胴体评分的强制性标准;其次,其他生产和加工领域的关键点控制评分被合并到一个模型当中,用来预测不同个体肌肉和烹饪技巧的可口性。MSA模型可以用来支持新的营销创新。已经有充分的证据表明,消费者愿意为优质牛肉付出高价。目前已出现几个零售的例子采用MSA可口性评分来给牛肉定价。这样胴体价值的计算方法即为每块零售肉质量乘以不同质量评分的价格,并按照零售价的比例支付牛肉生产者。该系统可以用不同的胴体性状相关的经济权重来计算。由于等级是基于持续的质量规模,生产者在这个系统中的质量和产量方面即便小有增加,也会获得相应的经济回报。MSA系统已经支撑了一个新的和创新的营销系统,该系统的定价是透明的,可以帮助生产者对肉品的质量和产量的调整作出明智的决定。MSA系统不仅在澳大利亚有效地用于预测牛肉的可口性,而且在其他国家也都证明了其应用的有效性。在欧洲启动的ProSafeBeef项目也表明,欧洲也可用类似MSA的系统进行肉类的分级。 | R POLKINGHORNE J M THOMPSON J F HOCQUETTE D W PETHICK 霍云龙 孟庆祥 | 2015 | 肉类研究2015，29，2： | 6 |
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