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| 1 | 关键基础设施及其安全管理显示文摘关键基础设施(CI)系统是复杂的、高度相互依存的、网络化的社会—技术系统,一旦系统被中断或者被破坏,将会对国民健康、国土安全、经济稳定以及政府的正常运转等产生重大的影响.主要研究关键基础设施及其安全管理过程中的若干问题,对CI的特点进行了分析和总结,建立了网络化CI系统的体系结构,并利用视图模型来描述系统,同时还给出了灾难处理的一般过程.最后,进一步探讨了如何使用系统工程的方法来分析和模拟网络化CI系统的运行方式、潜在的薄弱环节以及改进这些薄弱环节的实施方法. | 刘晓 张隆飙 Zhang W J Tu Y L | 2009 | 管理科学学报2009，12，6： | 22 |
| 2 | Comeld^TM Joints: A Novel Technique for Bonding Composites and Metal显示文摘Current and future structural applications for composite laminates frequently involve design solutions combining composite laminates and metal; the materials must be joined. Two conventional means of joining are available mechanical joining and adhesive bonding. Both methods have critical disadvantages. A novel surface treatment for metals developed at TWI, Surfi-Sculpt, leads to the formation of surface protrusions on metal surfaces. These protrusions are typically 1.0 mm high and 0.6 mm in diameter. The surface modified metal can be bonded with composite laminates to form a Comeld~TM joint. These joints can be described as a combination of mechanical fastening and adhesive bonding. This paper describes our current work using finite element modelling to optimize the protrusions in respect to their geometry and distribution. The simulations require multi-scale modelling techniques to transfer results between the global model of the whole joint and the unit cell models containing a protrusion. Results from the simulations show critical effects on stress distributions arising from changing protrusion geometry. These joints show significant advantages over conventional adhesive joining technologies and their application would allow improved performance for combinations of metal and composite laminates. | Tu W Guild F J Hogg P J | 2009 | 稀有金属材料与工程2009，38，A03： | 14 |
| 3 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 4 | 相关性和一致性:这对相仿概念和测量方法的回顾与阐明(英文)显示文摘一致性(agreement)和相关性(correlation)是两个广泛使用的概念,用来评估变量之间的关联。虽然二者相似且相关,但是它们代表关联完全不同的概念。评估变量之间的一致性假设变量测量的是相同的结构,而在变量测量完全不同的结构时也可以评估它们之间的相关性。这种概念上的差异就要求使用不同的统计方法,并且当评估一致性或相关性时,统计方法根据数据的分布和研究者的兴趣可能会有所不同。例如,Pearson相关性,作为评估连续变量之间相关性的一种普遍测量方法,只有用于符合线性关系的变量时才能提供有用的信息;当用于不符合线性关系的变量时就无法提供准确信息甚至会产生误导。同样地,内部相关性,作为一种评估连续变量之间一致性的常用方法,如果一致性不好的实质正好是研究兴趣所在,那么该测量就不能为研究者提供充分的信息。本报告回顾了一致性和相关性的概念,并讨论了几种常用方法在应用中的差异。 | Liu JY Tang W Chen GQ Lu Y Feng CY Tu XM | 2016 | 上海精神医学2016，28，2： | 6 |
| 5 | Inflammation and nutrition in children with chronic kidney disease显示文摘Chronic inflammation and nutritional imbalance are important comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease(CKD). Nutritional disorders such as cachexia/protein energy wasting, obesity and growth retardation negatively impact the quality of life and disease progression in children with CKD. Inadequate nutrition has been associated with growth disturbances in children with CKD. On the other hand, over-nutrition and obesity are associated with poor outcomes in children with CKD. The exact mechanisms leading to these unfavorable conditions are not fully elucidated and are most likely multifactorial. In this review, we focus on the pathophysiology of nutrition disorders and inflammation and their impact on clinical outcomes in children with CKD. | Juan Tu Wai W Cheung Robert H Mak | 2016 | World Journal of Nephrology2016，5，3： | 3 |
| 6 | Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25 (high) T cells in human STAT5b deficiency显示文摘 | Cohen A C Nadeau K C Tu W | 2006 | J Immunol2006，177，5： | 1 |
| 7 | Rapid synthesis of nanoscale colloidal metal clusters by microwave irradiation显示文摘 | Tu W X Liu H F | 2000 | J Mater Chem2000，10，9： | 1 |
| 8 | Ontogenesis of transthyretin gene expression in chicken choroids plexus and liver显示文摘 | Southwell B R Duan W Tu G F | 1991 | Comp Biochem Physiol1991，100，： | 1 |
| 9 | Active carbon-ceramic sphere as sup- port of ruthenium catalysts for catalytic wet air oxidation (CWAO) of resin effluent 显示文摘 | Liu W M Hu Y Q Tu S T | 2010 | J Hazard Mater2010，179，： | 1 |
| 10 | A fem that hyperaccumulates arsenic显示文摘 | Ma L Q Komar K M Tu C Zhang W H Cai Y Kennelley E D | 2001 | Nature2001，409，： | 1 |
| 11 | Comparison of spectral and image morphological analysis for egg early hatching propertydetection based on hyperspectral imaging 显示文摘 | Zhang W Pan L Q Tu K | 2014 | Plos ONE2014，9，2： | 1 |
| 12 | Baicalin inhibits TLR2/4 signa- ling pathway in rat brain following permanent cerebral ischemia 显示文摘 | Tu X K Yang W Z Shi S S | 2011 | Inflammation2011，34，5： | 1 |
| 13 | Material research for planar SOFC stack显示文摘 | T.-L Wen D Wang M Chen H Tu Z Lu Z Zhang H Nie W Huang | 2002 | Solid State Ionics2002，，3： | 1 |
| 14 | Sost down regulation and local Wnt signaling are required for the osteogenic response to mechanical loading显示文摘 | Tu X Rhee Y Condon K W | 2012 | Bone2012，50，1： | 1 |
| 15 | Synthesis of Bi6Mo2015sub-microwires via a molten salt method and enhancing thephotocatalytic reduction of CO2 into solar fuel through tuning the surface oxide vacancies by simple post-heating treatment显示文摘 | Li P Zhou Y Tu W Wang R Zhang C Liu Q Li H Li Z Dai H Wang J Yan S Zou Z | 2013 | CrystEngComm2013，15，46： | 1 |
| 16 | A rare case of unilateral adrenal hy- perplasia accompanied by hypokalaemie periodic paralysis caused by a novel dominant mutation in CACNA1S: features and prognosis afler adrenaleetomy显示文摘 | Yang B Yang Y Tu W | 2014 | BMC Urol2014，14，： | 1 |
| 17 | Confidence intervals for the mean of diagnostic test charge data containing zeros 显示文摘 | Zhou X and Tu W | 1998 | Biometrics1998，56，： | 1 |
| 18 | Celangulins II, III, and IV: new insecticidal sesquiterpenoids from Celastrus angulatus 显示文摘 | Wu W J Tu Y Q Liu H X | 1992 | J Nat Prod1992，55，9： | 1 |
| 19 | Surface plasmon resonance waveguide biosensor by bipolarization wavelength interrogation显示文摘 | WANG T J TU C W LIU F K | 2004 | IEEE Photonics Technology Letters2004，16，7： | 1 |
| 20 | Mercury speciation analysis in soil samples by ion chromatography, post-column cold vapor generation and inductively coupled plasma mass spectrometry 显示文摘 | TU Q JOHNSON W BUCKLEY B | 2003 | J Anal At Spectrom2003，，18： | 1 |
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